{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:38:20Z","timestamp":1770752300513,"version":"3.50.0"},"reference-count":63,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Regenerative endodontic treatment (RET) has emerged as a biologically based alternative to traditional apexification for managing immature permanent teeth with pulp necrosis. By promoting tissue ingrowth and continued root development, RET aims not only to eliminate infection but also to reinforce structurally compromised roots. Although its clinical use has expanded, evidence regarding the long-term predictability and durability of RET remains limited, as most published studies provide only short- or mid-term follow-up. Case presentation: This report describes two pediatric cases involving regenerative procedures performed on three immature permanent maxillary incisors, each followed for more than six years. The first case involved a 7-year-old girl who developed pulp necrosis in a maxillary lateral incisor after acute dental trauma. Management followed a regenerative protocol using triple antibiotic paste (ciprofloxacin, metronidazole, and minocycline) as intracanal medication and mineral trioxide aggregate as the coronal barrier. The second case concerned an 8-year-old girl presenting with chronic infection and sinus tracts affecting both maxillary central incisors. These teeth were treated using a regenerative approach with calcium hydroxide as the intracanal medicament and Biodentine as the sealing material. Clinical, radiographic, and cone beam computed tomography evaluations demonstrated complete symptom resolution and periapical healing but incomplete progressive apical closure. All treated teeth developed a calcified apical barrier, and outcomes remained stable throughout the extended follow-up period. Conclusions: While inherently limited by the nature of case reports, these findings support RET as a reliable and durable therapeutic option for necrotic immature permanent teeth, including cases in which conventional apexification has not been successful.<\/jats:p>","DOI":"10.3390\/children13020246","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:07:06Z","timestamp":1770725226000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regenerative Endodontic Treatment in Permanent Incisors: Two Case Reports with 6 Years of Follow-Up"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-0145","authenticated-orcid":false,"given":"Mar\u00eda","family":"Biedma-Perea","sequence":"first","affiliation":[{"name":"Department of Stomatology, Paediatric Dentistry, Faculty of Dentistry, University of Seville, C\/Avicena SN, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-7187","authenticated-orcid":false,"given":"Marcela","family":"Arenas-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Paediatric Dentistry, Faculty of Dentistry, University of Seville, C\/Avicena SN, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-7033","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Barra-Soto","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Paediatric Dentistry, Faculty of Dentistry, University of Seville, C\/Avicena SN, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Caleza-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Paediatric Dentistry, Faculty of Dentistry, University of Seville, C\/Avicena SN, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-9216","authenticated-orcid":false,"given":"David","family":"Ribas-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Paediatric Dentistry, Faculty of Dentistry, University of Seville, C\/Avicena SN, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1034\/j.1600-9657.2001.017004185.x","article-title":"Revascularization of an immature permanent tooth with apical periodontitis and sinus tract","volume":"17","author":"Iwaya","year":"2001","journal-title":"Dent. 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