{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:05:34Z","timestamp":1781103934326,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Transumbilical laparoscopic-assisted (TULA) surgery is a minimally invasive technique that combines laparoscopic exploration with extracorporeal surgical management, offering potential advantages in neonatal abdominal surgery. However, comparative data with conventional open surgery in neonates remain limited. This study reports our single-center experience with TULA and compares its outcomes with those of a matched cohort of neonates undergoing open surgery. Methods: We performed a retrospective study on neonatal patients (&lt;28 days of life) treated at our Pediatric Surgery Unit between 2015 and 2023. Twenty-five neonates underwent TULA for various intra-abdominal malformations. Each TULA patient was matched in a 1:2 ratio with neonates treated with open surgery based on gestational age, birth weight, and underlying diagnosis, resulting in a matched cohort of 50 patients. Primary outcomes included operative and anesthesia times, conversion rate, postoperative complications, length of hospital stay, and mortality. Results: The TULA cohort included 11 males and 14 females, with a mean gestational age of 37.5 \u00b1 1.9 weeks and a mean birth weight of 2989 \u00b1 675 g. Indications comprised intestinal malrotation, ileal atresia, duodenal stenosis, meconium ileus, and other abdominal pathologies. Mean operative time was comparable between groups (116 \u00b1 37 min in the TULA group vs. 137 \u00b1 65.9 min in the open surgery group; p = 0.52). Conversion from TULA to open surgery occurred in 16% of cases. No significant differences were observed in major postoperative complications or length of hospital stay between groups (p &gt; 0.05). No mortality was reported. Conclusions: TULA represents a safe and effective surgical option for selected neonatal abdominal pathologies, with outcomes comparable to conventional open surgery. When performed in specialized centers with appropriate patient selection and multidisciplinary expertise, TULA offers favorable safety and cosmetic results.<\/jats:p>","DOI":"10.3390\/children13030338","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:41:02Z","timestamp":1772188862000},"page":"338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transumbilical Laparoscopic-Assisted (TULA) Surgery for Treating Abdominal Pathologies in Newborns: A Retrospective Single-Center Experience"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-4985","authenticated-orcid":false,"given":"Giada","family":"Loria","sequence":"first","affiliation":[{"name":"Pediatric Surgery Unit, Department of Advanced Medical and Surgical Sciences G. Ingrassia, Policlinico G. Rodolico\u2014San Marco Hospital, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Aurora","family":"Aversa","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Advanced Medical and Surgical Sciences G. Ingrassia, Policlinico G. Rodolico\u2014San Marco Hospital, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fichera","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Advanced Medical and Surgical Sciences G. Ingrassia, Policlinico G. Rodolico\u2014San Marco Hospital, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Bartolone","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Advanced Medical and Surgical Sciences G. Ingrassia, Policlinico G. Rodolico\u2014San Marco Hospital, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-4539","authenticated-orcid":false,"given":"Vincenzo","family":"Di Benedetto","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Advanced Medical and Surgical Sciences G. Ingrassia, Policlinico G. Rodolico\u2014San Marco Hospital, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-1349","authenticated-orcid":false,"given":"Maria Grazia","family":"Scuderi","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Advanced Medical and Surgical Sciences G. Ingrassia, Policlinico G. Rodolico\u2014San Marco Hospital, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/01.sla.0000179649.15576.db","article-title":"Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula: A multi-institutional analysis","volume":"242","author":"Holcomb","year":"2005","journal-title":"Ann. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1053\/jpsu.2000.6925","article-title":"Laparoscopically assisted anorectal pull-through for high imperforate anus\u2014A new technique","volume":"35","author":"Georgeson","year":"2000","journal-title":"J. Pediatr. 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