{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:58:44Z","timestamp":1776722324176,"version":"3.51.2"},"reference-count":21,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Allergy to fluconazole is uncommon and even more so in lactating women receiving treatment as part of treatment for neonatal oral thrush. Methods: We report a case of a rare and unexpected adverse reaction occurring after a single dose of fluconazole (Diflucan), administered to a mother of an exclusively breastfed neonate with oral thrush, as per guideline recommendations. Results: The woman developed multiple symptomatic manifestations highly suspicious of a hypersensitivity reaction after 8 h of taking a single 150 mg dose which were managed with antihistamines and cessation of medication. The baby\u2019s symptoms abated with treatment and the mother whose hypersensitivity symptoms abated with treatment continued to breastfeed. Conclusion: We recommend that in prescribing antifungals to women whose babies have neonatal oral thrush, clinicians must always bear in mind that a history of previous allergic reaction(s) could signal the possibility of an allergic reaction to the antifungal agent. Counselling should therefore include the potential for reactions and steps to take if these develop. With supportive treatment, appropriate therapies and cessation of the medication, these invariably resolve. Where these persist, offering topical antifungal options may minimize the risk of recurrence of the hypersensitivity.<\/jats:p>","DOI":"10.3390\/children13030383","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:27:18Z","timestamp":1773062838000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal Allergy to Fluconazole\u2014An Unusual Presentation: Case Report in a Breastfeeding Mother"],"prefix":"10.3390","volume":"13","author":[{"given":"Amani G.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Feto Maternal Centre, Al Markhiya Street, Doha P.O. Box 2713, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shajna","family":"Kinarullakandi","sequence":"additional","affiliation":[{"name":"Feto Maternal Centre, Al Markhiya Street, Doha P.O. Box 2713, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badreldeen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Feto Maternal Centre, Al Markhiya Street, Doha P.O. Box 2713, Qatar"},{"name":"Obstetrics and Gynaecology, Qatar University, Doha P.O. Box 2713, Qatar"},{"name":"Obstetrics and Gynaecology, Weill Cornell Medicine, Doha P.O. Box 2713, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-6938","authenticated-orcid":false,"given":"Justin C.","family":"Konje","sequence":"additional","affiliation":[{"name":"Feto Maternal Centre, Al Markhiya Street, Doha P.O. Box 2713, Qatar"},{"name":"Obstetrics and Gynaecology, Weill Cornell Medicine, Doha P.O. Box 2713, Qatar"},{"name":"Obstetrics and Gynaecology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/myc.12355","article-title":"Prevalence of oral Candida in the first year of life","volume":"58","author":"Silfverdal","year":"2015","journal-title":"Mycoses"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"El-Dawy, E.G.A.M., Baddar, A., Gherbawy, Y.A., and Yassein, A.S. (2025). Characterization and virulence of yeasts associated with neonatal thrush. BMC Microbiol., 25.","DOI":"10.1186\/s12866-025-04075-4"},{"key":"ref_3","unstructured":"(2025, December 10). 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