{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:49:40Z","timestamp":1775198980782,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000262","name":"Fighting Blindness Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000262","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fonds de recherche en ophtalmologie de l\u2019Universit\u00e9 de Montr\u00e9al"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Purpose: This study aimed to comprehensively map the structural impacts of ROP on all ocular structures, including and extending beyond the inner retina and the associated long-term sequelae that manifest into adulthood. Methods: This scoping review identified studies on animal oxygen-induced retinopathy and clinical retinopathy of prematurity using a multi-database search. Study selection and data extraction were performed independently by multiple reviewers using Covidence software. Results: ROP results in lasting ocular complications. Posterior segment findings include choroidal insufficiency, photoreceptor dysfunction, and retinal detachment. Anterior segment complications involve a higher incidence of angle-closure glaucoma, strabismus, and significant myopia. Conclusions: This scoping review was conducted and reported in accordance with the PRISMA-ScR guidelines, though it is limited by the exclusion of non-English studies. Lifelong ophthalmic monitoring is essential for ROP patients due to persistent anterior and posterior segment complications. This study also identifies key future research priorities, including elucidating mechanisms of foveal development and conducting longitudinal studies. Furthermore, as neonatal intensive care expands in low and middle-income regions, international collaboration is vital to guide screening and treatment and prevent a debilitating surge of ROP.<\/jats:p>","DOI":"10.3390\/children13040483","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:41:53Z","timestamp":1774878113000},"page":"483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Sequelae of Retinopathy of Prematurity\u2014A Scoping Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-5648","authenticated-orcid":false,"given":"Philippe","family":"Gros-Louis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centre Universitaire d\u2019Ophtalmologie (CUO), H\u00f4pital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 3W5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwei Ellen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9573","authenticated-orcid":false,"given":"Weronika","family":"Jakubowska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison L.","family":"Dorfman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Universitaire (CHU) Sainte-Justine et Centre de Recherche du CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Polosa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Universitaire d\u2019Ophtalmologie (CUO), H\u00f4pital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 3W5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigufa","family":"Kahn Ali","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Universitaire d\u2019Ophtalmologie (CUO), H\u00f4pital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 3W5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4907-0117","authenticated-orcid":false,"given":"Valentina","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Medical Biochemistry, and Pathology, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3302-5754","authenticated-orcid":false,"given":"Cynthia X.","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Universitaire d\u2019Ophtalmologie (CUO), H\u00f4pital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, Montreal, QC H1T 3W5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.earlhumdev.2007.11.009","article-title":"Retinopathy of prematurity: A global perspective of the epidemics, population of babies at risk and implications for control","volume":"84","author":"Gilbert","year":"2008","journal-title":"Early Hum. 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