{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:41:15Z","timestamp":1790700075338,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Preterm birth interrupts critical phases of lung development and is associated with long-term alterations in respiratory structure and function. While bronchopulmonary dysplasia (BPD) has traditionally been considered the principal determinant of adverse outcomes, accumulating evidence indicates that prematurity per se contributes substantially to persistent pulmonary impairment. Lung function trajectories in preterm-born children frequently track along lower percentiles from infancy into adolescence and early adulthood, with limited catch-up growth and increased vulnerability to chronic airflow limitation. Assessment of lung function requires a developmentally tailored approach, as feasibility and interpretability vary across age groups. In infancy, non-volitional techniques such as tidal breathing flow-volume loop analysis and raised-volume rapid thoracoabdominal compression allow early evaluation of respiratory mechanics. During toddlerhood, methodological limitations persist, although emerging technologies may expand feasibility. In preschool children, impulse oscillometry enables detection of small airway dysfunction, often preceding spirometric abnormalities. From school age onward, spirometry, body plethysmography, diffusing capacity, and multiple breath washout provide complementary information on obstructive, restrictive, and gas-exchange impairments. Longitudinal studies demonstrate that reduced lung function is not confined to children with BPD and may predispose to early-onset chronic obstructive pulmonary disease-like phenotypes. Early identification of abnormal trajectories and modifiable risk factors supports structured long-term follow-up and preventive strategies. Standardization of age-specific assessment protocols and harmonization of reference values are essential to improve risk stratification and optimize long-term respiratory outcomes in this vulnerable population.<\/jats:p>","DOI":"10.3390\/children13040500","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:26:12Z","timestamp":1775121972000},"page":"500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lung Function Trajectories After Preterm Birth: A Life-Course Approach to Age-Specific Monitoring"],"prefix":"10.3390","volume":"13","author":[{"given":"Dorina","family":"Hoxha","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n\u00b05, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bucci","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n\u00b05, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Di Pillo","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n\u00b05, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n\u00b05, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-3160","authenticated-orcid":false,"given":"Marina","family":"Attanasi","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n\u00b05, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Via dei Vestini n\u00b05, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/1471-0528.12281","article-title":"Preterm birth time trends in Europe: A study of 19 countries","volume":"120","author":"Zeitlin","year":"2013","journal-title":"BJOG"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.15585\/mmwr.mm6543a1","article-title":"Effects of Maternal Age and Age-Specific Preterm Birth Rates on Overall Preterm Birth Rates\u2014United States, 2007 and 2014","volume":"65","author":"Callaghan","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41572-019-0127-7","article-title":"Bronchopulmonary dysplasia","volume":"5","author":"Goss","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary Disease Following Respirator Therapy of Hyaline-Membrane Disease","volume":"276","author":"Northway","year":"1967","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151817","DOI":"10.1016\/j.semperi.2023.151817","article-title":"Bronchopulmonary dysplasia\u2014Associated pulmonary hypertension: An updated review","volume":"47","author":"Varghese","year":"2023","journal-title":"Semin. Perinatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1203\/00006450-199912000-00007","article-title":"The new BPD: An arrest of lung development","volume":"46","author":"Jobe","year":"1999","journal-title":"Pediatr. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1002\/ppul.25341","article-title":"Bronchopulmonary dysplasia\u2014A historical perspective","volume":"56","author":"Allen","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/j.semperi.2018.09.001","article-title":"Recent advances in the pathogenesis of BPD","volume":"42","author":"Morty","year":"2018","journal-title":"Semin. Perinatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/jp.2011.68","article-title":"Outcomes of preterm infants 29 weeks gestation over 10-year period in Canada: A cause for concern","volume":"32","author":"Shah","year":"2012","journal-title":"J. Perinatol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Di Filippo, P., Giannini, C., Attanasi, M., Dodi, G., Scaparrotta, A., Petrosino, M.I., Di Pillo, S., and Chiarelli, F. (2021). Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.635503"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/ppul.25301","article-title":"Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life","volume":"56","author":"Collaco","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12931-021-01720-0","article-title":"Lung function trajectories in children with post-prematurity respiratory disease: Identifying risk factors for abnormal growth","volume":"22","author":"Levin","year":"2021","journal-title":"Respir. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Di Filippo, P., Dodi, G., Ciarelli, F., Di Pillo, S., Chiarelli, F., and Attanasi, M. (2022). Lifelong Lung Sequelae of Prematurity. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19095273"},{"key":"ref_14","unstructured":"Rehman, S., and Bacha, D. (2025). Embryology, Pulmonary. StatPearls NCBI Bookshelf, StatPearls Publishing."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ppul.25169","article-title":"Structural and functional development in airways throughout childhood: Children are not small adults","volume":"56","author":"Kantar","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1079\/PNS19960046","article-title":"Lung maturation","volume":"55","author":"Hume","year":"1996","journal-title":"Proc. Nutr. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Weaver, T.E., Nogee, L.M., and Jobe, A.H. (2016). Surfactant During Lung Development. Fetal and Neonatal Lung Development, Cambridge University Press.","DOI":"10.1017\/CBO9781139680349.009"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1002\/ppul.25380","article-title":"Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia","volume":"56","author":"Moschino","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40348-016-0051-9","article-title":"Pathogenesis of bronchopulmonary dysplasia: When inflammation meets organ development","volume":"3","author":"Shahzad","year":"2016","journal-title":"Mol. Cell. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1139\/cjpp-2014-0387","article-title":"Perinatal oxygen in the developing lung","volume":"93","author":"Vogel","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Balany, J., and Bhandari, V. (2015). Understanding the impact of infection, inflammation, and their persistence in the pathogenesis of bronchopulmonary dysplasia. Front. Med., 2.","DOI":"10.3389\/fmed.2015.00090"},{"key":"ref_22","unstructured":"Sahni, M., and Mowes, A.K. (2025). Bronchopulmonary Dysplasia. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12931-018-0837-5","article-title":"Understanding alveolarization to induce lung regeneration","volume":"19","author":"Ntokou","year":"2018","journal-title":"Respir. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/pr.2017.232","article-title":"Stem cell biology and regenerative medicine for neonatal lung diseases","volume":"83","author":"Kang","year":"2018","journal-title":"Pediatr. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dankhara, N., Holla, I., Ramarao, S., and Kalikkot Thekkeveedu, R. (2023). Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology. J. Clin. Med., 12.","DOI":"10.20944\/preprints202305.0591.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-4419-8997-0_8","article-title":"Hypoxia and Lung Branching Morphogenesis","volume":"543","author":"Gebb","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1586\/17476348.2013.838020","article-title":"Perinatal factors in neonatal and pediatric lung diseases","volume":"7","author":"Britt","year":"2013","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1056\/NEJMoa0911783","article-title":"Early CPAP versus surfactant in extremely preterm infants","volume":"362","author":"Finer","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1159\/000540078","article-title":"Less invasive surfactant administration for preterm infants-state of the art","volume":"121","author":"Kribs","year":"2024","journal-title":"Neonatology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00431-025-06713-5","article-title":"Follow-up of neonatal chronic respiratory disease: An update based on the current evidence","volume":"185","author":"Jenkinson","year":"2026","journal-title":"Eur. J. Pediatr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"240114","DOI":"10.1183\/16000617.0114-2024","article-title":"Impaired lung function and associated risk factors in children born prematurely: A systematic review and meta-analysis","volume":"33","author":"Hutten","year":"2024","journal-title":"Eur. Respir. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/ppul.26019","article-title":"Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity-associated obstructive lung disease","volume":"57","author":"Cousins","year":"2022","journal-title":"Pediatr. Pulmonol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107845","DOI":"10.1016\/j.rmed.2024.107845","article-title":"Pulmonary function using impulse oscillometry system and clinical outcomes at age 4 years in children born extremely preterm with or without bronchopulmonary dysplasia","volume":"234","author":"Delestrain","year":"2024","journal-title":"Respir. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"210016","DOI":"10.1183\/20734735.0016-2021","article-title":"Multiple breath washout: Measuring early manifestations of lung pathology","volume":"17","author":"Stanojevic","year":"2021","journal-title":"Breathe"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/ppul.25226","article-title":"Respiratory outcomes of \u201cnew\u201d bronchopulmonary dysplasia in adolescents: A multicenter study","volume":"56","author":"Medina","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2201519","DOI":"10.1183\/13993003.01519-2022","article-title":"European Respiratory Society\/American Thoracic Society technical statement: Standardisation of the measurement of lung volumes, 2023 update","volume":"62","author":"Bhakta","year":"2023","journal-title":"Eur. Respir. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1183\/09031936.05.00035005","article-title":"Standardisation of the measurement of lung volumes","volume":"26","author":"Wanger","year":"2005","journal-title":"Eur. Respir. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1900788","DOI":"10.1183\/13993003.00788-2019","article-title":"European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia","volume":"55","author":"Duijts","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s12098-023-04588-8","article-title":"Lung Function Tests in Infants and Children","volume":"90","author":"Jat","year":"2023","journal-title":"Indian J. Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0022-3476(86)80296-7","article-title":"Expiratory flow limitation in infants with bronchopulmonary dysplasia","volume":"109","author":"Tepper","year":"1986","journal-title":"J. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1164\/rccm.201601-0188OC","article-title":"Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness","volume":"195","author":"Gray","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"00163-2022","DOI":"10.1183\/23120541.00163-2022","article-title":"Infant tidal flow-volume parameters and arousal state","volume":"8","author":"Bains","year":"2022","journal-title":"ERJ Open Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/thoraxjnl-2015-207401","article-title":"Determinants of early-life lung function in African infants","volume":"72","author":"Gray","year":"2016","journal-title":"Thorax"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1136\/thoraxjnl-2015-207278","article-title":"New reference ranges for interpreting forced expiratory manoeuvres in infants and implications for clinical interpretation: A multicentre collaboration","volume":"71","author":"Lum","year":"2016","journal-title":"Thorax"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"American Thoracic Society, and European Respiratory Society (2005). ATS\/ERS Statement: Raised volume forced expirations in infants\u2014Guidelines for current practice. Am. J. Respir. Crit. Care Med., 172, 1463\u20131471.","DOI":"10.1164\/rccm.200408-1141ST"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1183\/18106838.0603.220","article-title":"Lung function during infancy and preschool age","volume":"6","author":"Carlsen","year":"2010","journal-title":"Breathe"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12931-019-1067-1","article-title":"Diagnostic accuracy of capnovolumetry for the identification of airway obstruction\u2014Results of a diagnostic study in ambulatory care","volume":"20","author":"Kellerer","year":"2019","journal-title":"Respir. Res."},{"key":"ref_48","first-page":"PA562","article-title":"Impedance pneumography in healthy and sick children aged between 2 and 36 months","volume":"66","author":"Beydon","year":"2025","journal-title":"Eur. Respir. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/apa.14769","article-title":"Mini review shows that structured light plethysmography provides a non-contact method for evaluating breathing patterns in children","volume":"108","author":"Lauhkonen","year":"2019","journal-title":"Acta Paediatr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1183\/09031936.03.00089403","article-title":"The forced oscillation technique in clinical practice: Methodology, recommendations and future developments","volume":"22","author":"Oostveen","year":"2003","journal-title":"Eur. Respir. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"210208","DOI":"10.1183\/16000617.0208-2021","article-title":"Clinical significance and applications of oscillometry","volume":"31","author":"Kaminsky","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"00138-2018","DOI":"10.1183\/23120541.00138-2018","article-title":"Interdevice agreement in respiratory resistance values by oscillometry in asthmatic children","volume":"5","author":"Ducharme","year":"2019","journal-title":"ERJ Open Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"560","DOI":"10.24953\/turkjped.2019.04.013","article-title":"Impulse oscillometry reference values and correlation with predictors in Turkish preschool children","volume":"61","author":"Er","year":"2019","journal-title":"Turk. J. Pediatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1080\/02770903.2020.1779289","article-title":"Long-term effects of bronchopulmonary dysplasia on lung function: A pilot study in preschool children\u2019s cohort","volume":"58","author":"Manti","year":"2021","journal-title":"J. Asthma"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of spirometry 2019 update an official American Thoracic Society and European Respiratory Society technical statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2101499","DOI":"10.1183\/13993003.01499-2021","article-title":"ERS\/ATS technical standard on interpretive strategies for routine lung function tests","volume":"60","author":"Stanojevic","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Bjelica, M., Vilotijevi\u0107 Dautovi\u0107, G., Spasojevi\u0107, S., Radovanovi\u0107, T., and Plaza\u010di\u0107, M. (2025). Respiratory Sequelae of Prematurity in School-Age Children: Is Bronchopulmonary Dysplasia Still the Primary Risk Factor?. Children, 13.","DOI":"10.3390\/children13010005"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1183\/13993003.00478-2015","article-title":"Functional evidence for continued alveolarisation in former preterms at school age?","volume":"46","author":"Yammine","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Schmalisch, G., Wilitzki, S., Roehr, C.C., Proquitt\u00e9, H., and B\u00fchrer, C. (2012). Development of lung function in very low birth weight infants with or without bronchopulmonary dysplasia: Longitudinal assessment during the first 15 months of corrected age. BMC Pediatr., 12.","DOI":"10.1186\/1471-2431-12-37"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Muehlbacher, T., Bassler, D., and Bryant, M.B. (2021). Evidence for the management of bronchopulmonary dysplasia in very preterm infants. Children, 8.","DOI":"10.3390\/children8040298"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/physrev.00042.2024","article-title":"The evolving pathophysiology of bronchopulmonary dysplasia","volume":"106","author":"Ambalavanan","year":"2026","journal-title":"Physiol. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1600016","DOI":"10.1183\/13993003.00016-2016","article-title":"2017 ERS\/ATS standards for single-breath carbon monoxide uptake in the lung","volume":"49","author":"Graham","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Um-Bergstr\u00f6m, P., Hallberg, J., Thunqvist, P., Berggren-Brostr\u00f6m, E., Anderson, M., Adenfelt, G., Lilja, G., Ferrara, G., Sk\u00f6ld, C.M., and Mel\u00e9n, E. (2017). Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia. BMC Pulm. Med., 17.","DOI":"10.1186\/s12890-017-0441-3"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Saglani, S., and Menzie-Gow, A.N. (2019). Approaches to asthma diagnosis in children and adults. Front. Pediatr., 7.","DOI":"10.3389\/fped.2019.00148"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.1038\/s41598-023-34233-5","article-title":"Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia","volume":"13","author":"Course","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Di Filippo, P., Dodi, G., Di Pillo, S., Chiarelli, F., and Attanasi, M. (2022). Effect of Invasive Mechanical Ventilation at Birth on Lung Function Later in Childhood. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.912057"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Chen, D., Chen, J., Cui, N., Cui, M., Chen, X., Zhu, X., and Zhu, X. (2020). Respiratory Morbidity and Lung Function Analysis During the First 36 Months of Life in Infants with Bronchopulmonary Dysplasia (BPD). Front. Pediatr., 7.","DOI":"10.3389\/fped.2019.00540"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"240178","DOI":"10.1183\/20734735.0178-2024","article-title":"Reflections of a paediatric pulmonologist: Strategies for optimising lung function tests in preschool children","volume":"21","author":"Gheorghiu","year":"2025","journal-title":"Breathe"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1183\/13993003.00415-2015","article-title":"Lung function in children in relation to ethnicity, physique and socioeconomic factors","volume":"46","author":"Lum","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/ppul.23919","article-title":"Lung function after extremely preterm birth\u2014A population-based cohort study (EXPRESS)","volume":"53","author":"Thunqvist","year":"2018","journal-title":"Pediatr. Pulmonol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/ppul.27287","article-title":"Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age","volume":"59","author":"Stein","year":"2024","journal-title":"Pediatr. Pulmonol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e70874","DOI":"10.1096\/fj.202500394RR","article-title":"Integrated Transcriptome and Metabolome Analysis Reveals a Disturbance in Antioxidant Metabolism Associated with the Progression of Bronchopulmonary Dysplasia","volume":"39","author":"Jia","year":"2025","journal-title":"FASEB J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s12931-024-02996-8","article-title":"Reinitiating lung development: A novel approach in the management of bronchopulmonary dysplasia","volume":"25","author":"Cui","year":"2024","journal-title":"Respir. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/ppul.22714","article-title":"Chest CT in bronchopulmonary dysplasia: Clinical and radiological correlations","volume":"48","author":"Spadola","year":"2013","journal-title":"Pediatr. Pulmonol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s00247-023-05598-6","article-title":"Assessment of lung ventilation of premature infants with bronchopulmonary dysplasia at 1.5 Tesla using phase-resolved functional lung magnetic resonance imaging","volume":"53","author":"Dyke","year":"2023","journal-title":"Pediatr. Radiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1164\/rccm.202008-3131OC","article-title":"Lung ultrasound to monitor extremely preterm infants and predict bronchopulmonary dysplasia a multicenter longitudinal cohort study","volume":"203","author":"Loi","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1183\/20734735.008417","article-title":"Wearable technology: Role in respiratory health and disease","volume":"13","author":"Aliverti","year":"2017","journal-title":"Breathe"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Leigh, R.M., Pham, A., Rao, S.S., Vora, F.M., Hou, G., Kent, C., Rodriguez, A., Narang, A., Tan, J.B.C., and Chou, F. (2022). Machine learning for prediction of bronchopulmonary dysplasia-free survival among very preterm infants. BMC Pediatr., 22.","DOI":"10.1186\/s12887-022-03602-w"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1002\/ppul.27216","article-title":"Combining artificial intelligence and conventional statistics to predict bronchopulmonary dysplasia in very preterm infants using routinely collected clinical variables","volume":"59","author":"Montagna","year":"2024","journal-title":"Pediatr. 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