{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:14:40Z","timestamp":1777868080586,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Rheumatic heart disease (RHD) remains a significant public health problem in low- and middle-income countries. Beyond its clinical consequences, RHD adversely affects the health-related quality of life (HRQoL) of affected children and adolescents, their families, and healthcare systems. Addressing the HRQoL of children and adolescents with RHD will contribute to strengthening patient-centered care and policy development. Objective: To determine the health-related quality of life of children and adolescents with rheumatic heart disease attending follow-up at the pediatric cardiology clinic of Moi Teaching and Referral Hospital (MTRH), Kenya. Methods: This was a hospital-based cross-sectional study conducted between January and July 2024. A total of 171 children and adolescents aged 5\u201318 years were consecutively enrolled while attending follow-up at the pediatric cardiology clinic of MTRH. The EuroQol EQ-5D-Y and EQ-5D-L questionnaires were used to assess HRQoL across five domains: mobility, self-care, usual activities, pain\/discomfort, and anxiety\/depression. Overall HRQoL was evaluated using the EQ visual analog scale (EQ-VAS) and categorized as optimal (\u226580%), suboptimal (70\u201379%), or poor (\u226470%). Results: Overall HRQoL was optimal in 70.8% (n = 121) of participants, suboptimal in 8.2% (n = 14), and poor in 21.1% (n = 36). Impaired HRQoL was significantly associated with poor self-care (95% CI: 0.066\u20130.853; p = 0.028), anxiety\/depression (95% CI: 0.111\u20130.678; p = 0.005), pain\/discomfort (95% CI: 0.142\u20130.758; p = 0.009) and missing more than five school days (95% CI: 0.109\u20130.584; p = 0.001). Caregiver characteristics (age, education level, and income), surgical correction, RHD-related hospital admissions, comorbidities, and Ross classification were not significantly associated with HRQoL. Conclusion: Health-related quality of life among children and adolescents with RHD was most adversely affected in the mental health and mobility domains. Routine assessment of HRQoL should be incorporated into the clinical care of children and adolescents with RHD to reduce disease-related morbidity and support holistic management.<\/jats:p>","DOI":"10.3390\/children13050623","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:47:28Z","timestamp":1777546048000},"page":"623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the Quality of Life of Children and Adolescents with Rheumatic Heart Disease in Moi Teaching and Referral Hospital Eldoret, Kenya"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1429-4153","authenticated-orcid":false,"given":"Myra Maghasi","family":"Koech","sequence":"first","affiliation":[{"name":"Department of Child Health and Paediatrics, School of Medicine, Moi University, P.O. Box 4606, Eldoret 30100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-7379","authenticated-orcid":false,"given":"Njie Albertine","family":"Enjema","sequence":"additional","affiliation":[{"name":"Academic Model Providing Access to Healthcare, P.O. Box 4606, Eldoret 30100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juddy","family":"Wachira","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Behavioral Sciences, School of Medicine, Moi University, P.O. Box 4606, Eldoret 30100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kazahura, P.T., Mushi, T.L., Pallangyo, P., Janabi, M., Kisenge, R., Albaghdadi, M., Majani, N., and Kija, E. (2021). 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