{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:03:49Z","timestamp":1780549429605,"version":"3.54.1"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: An infantile hemangioma (IH) is a benign lesion that develops as a result of pathologically dysregulated proliferation of the endothelial cells of the capillaries, typically appearing within the first three years of life. The disease is found mostly on the skin and\u2014less often\u2014in the internal organs. Although IH generally has a good prognosis and may sometimes undergo spontaneous regression, certain types of IH with a specific form, localization, and size may lead to life-threatening conditions including impairment of vital functions. This determines the need for precise diagnostics and treatment. Case presentation: The paper presents a clinical observation of an infant in the first months of life with IH presenting as diffuse hepatic hemangiomatosis and a hemangioma of the left eyebrow area. The IH was associated with life-threatening conditions. However, effective treatment with the non-selective \u03b2-adrenoblocker propranolol led to a positive outcome and the resolution of complications. Conclusions: This case demonstrates the critical importance of timely diagnosis and treatment for lesions that, while benign, can lead to fatal complications if not addressed promptly.<\/jats:p>","DOI":"10.3390\/children13060747","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:36:56Z","timestamp":1779892616000},"page":"747","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Life-Threatening Complications and Intensive Care of Diffuse Neonatal Hemangiomatosis of the Liver in a One-Month-Old Girl: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"given":"Regina R.","family":"Tukhvatullina","sequence":"first","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nune V.","family":"Matinyan","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliy A.","family":"Akimov","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa V.","family":"Milutis","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana S.","family":"Belysheva","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana R.","family":"Turkia","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V.","family":"Chufistova","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzel M.","family":"Muftakhova","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julietta A.","family":"Karmanova","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly P.","family":"Kazantsev","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera V.","family":"Reshetnikova","sequence":"additional","affiliation":[{"name":"Research Institute of Experimental Oncology and Carcinogenesis, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 24, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur T.","family":"Valiev","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill I.","family":"Kirgizov","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana V.","family":"Gorbunova","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana R.","family":"Varfolomeeva","sequence":"additional","affiliation":[{"name":"Research Institute of Pediatric Oncology and Hematology, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 23, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-3158","authenticated-orcid":false,"given":"Irina Zh.","family":"Shubina","sequence":"additional","affiliation":[{"name":"Research Institute of Experimental Oncology and Carcinogenesis, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 24, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Kiselevskiy","sequence":"additional","affiliation":[{"name":"Research Institute of Experimental Oncology and Carcinogenesis, FSBI \u201cN.N. Blokhin National Medical Research Center of Oncology\u201d of the Ministry of Health of Russia, Kashirskoye Sh. 24, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sandru, F., Turenschi, A., Constantin, A.T., Dinulescu, A., Radu, A.-M., and Rosca, I. (2023). Infantile Hemangioma: A Cross-Sectional Observational Study. Life, 13.","DOI":"10.3390\/life13091868"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1651-2227.1999.tb01276.x","article-title":"Diffuse neonatal haemangiomatosis: New views on diagnostic criteria and prognosis","volume":"88","author":"Lopriore","year":"1999","journal-title":"Acta Paediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1525-1470.2008.00626.x","article-title":"Infantile hemangiomas: How common are they? 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