{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:56:46Z","timestamp":1781697406069,"version":"3.54.5"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Advanced technologies in type 1 diabetes mellitus (T1DM) management have reshaped the strategies used to achieve optimal glucose control. Continuous subcutaneous insulin infusion (CSII) and automated insulin delivery (AID) systems are effective alternatives to multiple daily injections (MDI). This study aims to evaluate glycemic regulation in children and adolescents transitioning from MDI to insulin pumps and to raise awareness among patients and their families regarding the benefits of these systems. Methods: 50 pediatric patients with T1DM (24 males, 26 females; mean age 10.76 \u00b1 3.2 years) were evaluated. Cycle 1 established MDI metrics 3 months pre-transition. In cycle 2, patients transitioned either to an AID system (Medtronic MiniMed 780G, (Northridge, CA, USA), 78%), or a non-automated system (Omnipod DASH, 22%). Data were assessed at 3 and 6 months post-initiation. Parameters assessed were glycosylated hemoglobin (HbA1c), time in range (TIR), time above range (TAR), time below range (TBR), glucose management indicator (GMI) and coefficient of variation (CV). Results: The cohort exhibited a statistically significant increase in TIR (p = 0.0038) with mean values of 70.9% at 3 months and 73.2% at 6 months. TAR significantly reduced (p = 0.033) to 26.5% and 24.3% at 3 and 6 months, respectively. Sub-analysis in the AID group revealed a marked increase in TIR (p = 0.0001) alongside significant reductions in TAR (p = 0.0009) and GMI (p = 0.03). Conclusions: Transitioning from MDI to insulin pump therapy, particularly AID systems, leads to modest but significant improvements in specific sensor metrics (TIR, TAR) in real-world clinical practice. The consistency of these results across age groups indicates that AID systems can successfully overcome pediatric and adolescent diabetes management challenges.<\/jats:p>","DOI":"10.3390\/children13060819","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:19:53Z","timestamp":1781691593000},"page":"819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Insulin Pump Therapy on Glycemic Regulation in Children and Adolescents with Type 1 Diabetes Mellitus\u2014Preliminary Data from a Single Tertiary Pediatric Center"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9253-3438","authenticated-orcid":false,"given":"Maria","family":"Athanasopoulou","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Patras, University of Patras School of Medicine, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3127-0919","authenticated-orcid":false,"given":"Maria","family":"Tsanti","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Patras, University of Patras School of Medicine, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-989X","authenticated-orcid":false,"given":"Marios","family":"Papasotiriou","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, University Hospital of Patras, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-3011","authenticated-orcid":false,"given":"Alexandra","family":"Efthymiadou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Patras, University of Patras School of Medicine, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-5027","authenticated-orcid":false,"given":"Aristeidis","family":"Giannakopoulos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Patras, University of Patras School of Medicine, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-9207","authenticated-orcid":false,"given":"Dionisios","family":"Chrysis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Patras, University of Patras School of Medicine, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-7537","authenticated-orcid":false,"given":"Eirini","family":"Kostopoulou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Patras, University of Patras School of Medicine, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref_1","unstructured":"(2026, April 15). Diabetes Mellitus Type 1. Physiopedia. Available online: https:\/\/www.physio-pedia.com\/index.php?title=Diabetes_Mellitus_Type_1&oldid=373688."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2009). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 32, S62\u2013S67.","DOI":"10.2337\/dc09-S062"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e13562","DOI":"10.1111\/1753-0407.13562","article-title":"Epidemiology of type 1 diabetes mellitus in children and adolescents: A 50-year, single-center experience","volume":"16","author":"Kandemir","year":"2024","journal-title":"J. Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/pedi.13454","article-title":"ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents","volume":"23","author":"Libman","year":"2022","journal-title":"Pediatr. Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dci18-0023","article-title":"Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association","volume":"41","author":"Chiang","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_6","unstructured":"Lawrence, J.M., Casagrande, S.S., Herman, W.H., Wexler, D.J., and Cefalu, W.T. (2025, December 29). Prevalence and Incidence of Type 1 Diabetes Among Children and Adults in the United States and Comparison with Other Countries, Diabetes in America, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK619992\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109083","DOI":"10.1016\/j.diabres.2021.109083","article-title":"Global estimates of incidence of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Atlas, 10th edition","volume":"183","author":"Ogle","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_8","unstructured":"(2025, December 18). Diabetes Atlas. Global Diabetes Data & Insights|IDF Diabetes Atlas. Available online: https:\/\/diabetesatlas.org\/data-by-location\/global\/."},{"key":"ref_9","first-page":"2338922","article-title":"Trends in the Incidence of Type 1 Diabetes in European Children and Adolescents from 1994 to 2022: A Systematic Review and Meta-Analysis","volume":"2024","author":"Mesas","year":"2024","journal-title":"Pediatr. Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/dme.13681","article-title":"Incidence of childhood Type 1 diabetes mellitus in Crete","volume":"35","author":"Mamoulakis","year":"2018","journal-title":"Diabet. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41390-020-0899-1","article-title":"Seasonal variation and epidemiological parameters in children from Greece with type 1 diabetes mellitus (T1DM)","volume":"89","author":"Kostopoulou","year":"2020","journal-title":"Pediatr. Res."},{"key":"ref_12","unstructured":"Lucier, J., and Mathias, P.M. (2026). Type 1 Diabetes, StatPearls."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2019). 13. Children and Adolescents: Standards of Medical Care in Diabetes\u20142019. Diabetes Care, 42, S148\u2013S164.","DOI":"10.2337\/dc19-S013"},{"key":"ref_14","unstructured":"Los, E., and Wilt, A.S. (2026). Type 1 Diabetes in Children, StatPearls."},{"key":"ref_15","unstructured":"National Institute for Health and Care Excellence (2025, December 18). Diabetes (Type 1 and Type 2) in Children and Young People: Diagnosis and Management (NICE Guideline NG18). Available online: https:\/\/www.nice.org.uk\/guidance\/ng18."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Passanisi, S., Chobot, A., and Piona, C. (2025). Glycemic Control in Children and Adolescents with Type 1 Diabetes: From Challenges to Innovation. Children, 12.","DOI":"10.3390\/children12060708"},{"key":"ref_17","unstructured":"NHS (2024, October 14). CGM and HCL for Diabetes. Available online: https:\/\/www.nhs.uk\/tests-and-treatments\/cgm-and-hcl-for-diabetes\/."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117955142095907","DOI":"10.1177\/1179551420959077","article-title":"Quality of Life in Children with Diabetes Treated with Insulin Pump Compared with Multiple Daily Injections in Tertiary Care Center","volume":"13","author":"Qari","year":"2020","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2019). 7. Diabetes Technology: Standards of Medical Care in Diabetes\u20142019. Diabetes Care, 42, S71\u2013S80.","DOI":"10.2337\/dc19-S007"},{"key":"ref_20","first-page":"433","article-title":"Insulin pump treatment in children and adolescents with type 1 diabetes","volume":"64","author":"Hofer","year":"2012","journal-title":"Minerva Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/pedi.13421","article-title":"ISPAD Clinical Practice Consensus Guidelines 2022: Insulin delivery","volume":"23","author":"Sherr","year":"2022","journal-title":"Pediatr. Diabetes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1210\/endrev\/bnac022","article-title":"Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice","volume":"44","author":"Phillip","year":"2023","journal-title":"Endocr. Rev."},{"key":"ref_23","unstructured":"Circulars, T. (2023, January 15). 360\/23.12.2022 \u03a0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a0\u03b1\u03c1\u03b1\u03c1\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u0399 \u03c3\u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 47 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395A\u039b\u0395\/\u0393.\u03a0. 80157\/31-10-2018 \u03ba\u03bf\u03b9\u03bd\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7\u03c2 \u00ab\u03a4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u2019 \u03b1\u03c1. \u0395A\u039b\u0395\/\u0393.\u03a0. 46846\/ 19-06-2018 (\u0392\u2019 2315) \u03ba\u03bf\u03b9\u03bd\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7\u03c2, \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u201c\u0395\u03bd\u03b9\u03b1\u03af\u03bf\u03c2 \u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03a0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd \u03a5\u03b3\u03b5\u03af\u03b1\u03c2 (\u0395\u039a\u03a0\u03a5) \u03c4\u03bf\u03c5 \u0395\u03b8\u03bd\u03b9\u03ba\u03bf\u03cd O\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03a0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd \u03a5\u03c0\u03b7\u03c1\u03b5\u03c3\u03b9\u03ce\u03bd \u03a5\u03b3\u03b5\u03af\u03b1\u03c2 (\u0395O\u03a0\u03a5\u03a5)\u201d\u00bb (\u0392\u2019 4898), \u03cc\u03c0\u03c9\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395A\u039b\u0395\/ \u0393.\u03a0. 47749\/14-12-2022 \u03ba\u03bf\u03b9\u03bd\u03ae \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 A\u03bd\u03b1\u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ae \u03a5\u03c0\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd O\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03a5\u03c0\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd \u03a5\u03b3\u03b5\u03af\u03b1\u03c2 (\u0392\u2019 6544). Available online: https:\/\/www.taxheaven.gr\/circulars\/42307\/360-23-12-2022."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1464-5491.2007.02224.x","article-title":"Indications for insulin pump therapy in different age groups\u2014An analysis of 1567 children and adolescents","volume":"24","author":"Kapellen","year":"2007","journal-title":"Diabet. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/dia.2017.0130","article-title":"Challenges of diabetes management in toddlers","volume":"19","author":"Deeb","year":"2017","journal-title":"Diabetes Technol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/pch\/4.1.57","article-title":"The infant and toddler with diabetes: Challenges of diagnosis and management","volume":"4","author":"Daneman","year":"1999","journal-title":"Paediatr. Child Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1159\/000543156","article-title":"International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guidelines 2024 Diabetes Technologies: Glucose Monitoring","volume":"97","author":"Tauschman","year":"2025","journal-title":"Horm. Res. Paediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/pedi.13455","article-title":"ISPAD Clinical Practice Consensus Guidelines 2022: Glycemic targets and glucose monitoring for children, adolescents, and young people with diabetes","volume":"23","author":"Codner","year":"2022","journal-title":"Pediatr. Diabetes"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1089\/dia.2022.0313","article-title":"MiniMed 780GTM in 2- to 6-Year-Old Children: Safety and clinical outcomes after the first 12 weeks","volume":"25","author":"Pulkkinen","year":"2022","journal-title":"Diabetes Technol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.2337\/dc22-2046","article-title":"Safety of Real-life Usage of Advanced Hybrid Closed-Loop System MiniMed 780G in Children With Type 1 Diabetes Younger Than 7 Years Old","volume":"46","author":"Tornese","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bombaci, B., Calderone, M., Di Pisa, A., La Rocca, M., Torre, A., Lombardo, F., Salzano, G., and Passanisi, S. (2025). Impact of Automated Insulin Delivery Systems in Children and Adolescents with Type 1 Diabetes Previously Treated with Multiple Daily Injections: A Single-Center Real-World Study. Medicina, 61.","DOI":"10.3390\/medicina61091602"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2337\/dc20-2250","article-title":"Improved Glycemic Outcomes With Medtronic MiniMed Advanced Hybrid Closed-Loop Delivery: Results From a Randomized Crossover Trial Comparing Automated Insulin Delivery With Predictive Low Glucose Suspend in People With Type 1 Diabetes","volume":"44","author":"Collyns","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4274\/jcrpe.5117","article-title":"Effectiveness of Continuous Subcutaneous Insulin Infusion Pump Therapy During Five Years of Treatment on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus","volume":"10","author":"Korkmaz","year":"2018","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.aed.2025.12.012","article-title":"Continuous subcutaneous insulin infusion versus multiple daily injections for glycemic control in pediatric patients with Type 1 diabetes mellitus: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis","volume":"13","author":"Martinez","year":"2025","journal-title":"AACE Endocrinol. Diabetes"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/6\/819\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:27:19Z","timestamp":1781695639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/6\/819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["children13060819"],"URL":"https:\/\/doi.org\/10.3390\/children13060819","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]}}}