{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:13:42Z","timestamp":1783401222548,"version":"3.54.6"},"reference-count":112,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Upper respiratory tract infections and inflammatory nasal disorders are highly prevalent in childhood and represent a major cause of morbidity and healthcare utilization. Humans are continuously exposed to airborne microorganisms, allergens, and pollutants. Although the nasal mucosa provides effective mechanical and immunological defenses, these mechanisms may be impaired by inflammation, environmental pollutants, and mucociliary dysfunction, increasing susceptibility to infection and airway inflammation. Nasal irrigation (NI) contributes to the restoration of nasal homeostasis by mechanically removing mucus, pathogens, allergens, and inflammatory mediators, while also improving mucociliary clearance (MC), mucus rheology, and epithelial barrier function. Hypertonic solutions (HS) may provide additional osmotic and decongestant effects. Current evidence suggests that NI is a safe and well-tolerated adjunctive intervention that may improve symptoms and support mucosal function in acute and chronic upper airway diseases. This narrative review provides an updated overview of NI, with particular focus on pediatric populations. This paper integrates the pathophysiological mechanisms of mucociliary dysfunction, environmental exposures, and pediatric-specific anatomical and functional characteristics into a unified framework to understand the role of NI in childhood respiratory diseases. Clinical indications, administration techniques, solution selection, safety aspects, and age-specific practical considerations are discussed, highlighting the importance of appropriate technique, caregiver education, and adherence to basic hygiene principles.<\/jats:p>","DOI":"10.3390\/children13070851","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:43:57Z","timestamp":1782463437000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nasal Irrigation in Children: From Pathophysiological Rationale to Clinical Practice"],"prefix":"10.3390","volume":"13","author":[{"given":"Luca","family":"Pecoraro","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Pediatric Section, University of Salento Hospital \u201cVito Fazzi\u201d, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dell\u2019Anna","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Ospedale Vito Fazzi, ASL Lecce, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Di Muri","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Ospedale Vito Fazzi, ASL Lecce, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Altavilla","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Ospedale Vito Fazzi, ASL Lecce, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Marasciulo","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Ospedale Vito Fazzi, ASL Lecce, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Signore","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Ospedale Vito Fazzi, ASL Lecce, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Indrio","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Pediatric Section, University of Salento Hospital \u201cVito Fazzi\u201d, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199700541-00003","article-title":"Recurrent Respiratory Tract Infections in Paediatric Patients","volume":"54","author":"Bellanti","year":"1997","journal-title":"Drugs"},{"key":"ref_2","first-page":"13","article-title":"The child with recurrent respiratory infections: Normal or not?","volume":"18","author":"Ballotti","year":"2007","journal-title":"Pediatr. 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