{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:44:25Z","timestamp":1782823465458,"version":"3.54.5"},"reference-count":19,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: In the literature, the occurrence of menarche, the index of female sexual maturation, is related to chronological age (CA), but in conditions of abnormal growth it was proposed that determination of bone age (BA) was a better index of pubertal maturation than CA. Aim: To compare CA with BA at menarche in girls with Laron Syndrome (LS), a model of genetic IGF-I deficiency, which causes severe dwarfism and delayed puberty. Subjects: Data were retrieved retrospectively from our medical records. Nine untreated and four IGF-I-treated girls with LS were included in the study. Eleven GH-treated girls with congenital isolated GH deficiency (cIGHD) served as comparison. Results: The mean BA at menarche of untreated LS patients (13.4 y) was 0.7 y less than the CA (14.1 y), and the mean BA of IGF-I-treated girls (13.7 y) was 1.2 y less than the CA (14.9 y). Body height and weight did not influence the age at menarche. Conclusion: In girls with LS, the determination of BA seems a more useful index of female pubertal maturation than CA.<\/jats:p>","DOI":"10.3390\/children13070861","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:01:17Z","timestamp":1782813677000},"page":"861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison Between Chronological and Bone Age at Menarche in Girls with Laron Syndrome"],"prefix":"10.3390","volume":"13","author":[{"given":"Avivah","family":"Silbergeld","sequence":"first","affiliation":[{"name":"Endocrinology and Diabetes Research Unit, Schneider Children\u2019s Medical Center, Petah Tikva 4920235, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-5758","authenticated-orcid":false,"given":"Zvi","family":"Laron","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes Research Unit, Schneider Children\u2019s Medical Center, Petah Tikva 4920235, Israel"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","unstructured":"Golub, S. (1983). Menarche: The transition from girl to woman. Women Health 1983, Lexington Books."},{"key":"ref_2","unstructured":"Conk, V. (2025). Oxford English Dictionary, Oxford University Press."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1034\/j.1600-0463.2001.d01-107.x","article-title":"Age of puberty: Data from the United States of America","volume":"109","author":"Lee","year":"2001","journal-title":"APMIS"},{"key":"ref_4","first-page":"266","article-title":"Long-term secular trends in the age at menarche in Israel: A Systematic Literature Review and Pooled Analysis","volume":"8","author":"Weil","year":"2014","journal-title":"Horm. Res. Paediatr."},{"key":"ref_5","first-page":"140","article-title":"The height and weight of girls and boys at the time of initiation of the adolescent growth spurt in height and weight and the relationship to menarche","volume":"43","author":"Frisch","year":"1971","journal-title":"Hum. Biol."},{"key":"ref_6","first-page":"E51","article-title":"Meta-analysis of genome-wide association data identifies two loci influencing age at menarche","volume":"24","author":"Perry","year":"2005","journal-title":"Clin. Sports Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0022-3476(67)80420-7","article-title":"A comparison of skeletal growth and maturation in undernourished and well-nourished girls before and after menarche","volume":"70","author":"Dreizen","year":"1967","journal-title":"J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.csm.2005.01.003","article-title":"The menstrual cycle and sport performance","volume":"24","author":"Constantini","year":"2005","journal-title":"Clin. Sports Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/jc.2003-031033","article-title":"Laron syndrome (primary growth hormone resistance or insensitivity): The personal experience 1958\u20132003","volume":"89","author":"Laron","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00442408","article-title":"Puberty in Laron Type Dwarfism","volume":"134","author":"Laron","year":"1980","journal-title":"Eur. J. Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2307\/1125405","article-title":"Physiological age, a fundamental principle","volume":"15","author":"Crampton","year":"1944","journal-title":"Child Dev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1515\/JPEM.2006.19.8.979","article-title":"The relationship between dental age, chronological age and bone age in Turkish adolescents with constitutional delay of growth","volume":"19","author":"Kanbur","year":"2006","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1515\/jpem-2026-0043","article-title":"Age and sexual maturation at Spermarche in boys with Laron syndrome","volume":"39","author":"Laron","year":"2026","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_14","unstructured":"Rabin, T., Shinar, Y., and Laron, Z. (J. Clin. Endocrinol. Metab., 2026). LARON SYNDROME. (Growth Hormone Insensitivity) Geographical distribution and relationship to the genetic defects in the growth hormone receptor gene, J. Clin. Endocrinol. Metab., in press."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1054\/ghir.2001.0203","article-title":"Diagnosis and management of growth hormone deficiency in childhood and adolescence. Part 1: Diagnosis of growth hormone deficiency","volume":"11","author":"Sizonenko","year":"2001","journal-title":"Growth Horm. IGF Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4274\/jcrpe.v2i2.52","article-title":"Genetics of isolated growth hormone deficiency","volume":"2","author":"Mullis","year":"2010","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_17","unstructured":"Greulich, W.W., and Pyle, S.I. (1964). Radiographic Atlas of Skeletal Development, Oxford University Press."},{"key":"ref_18","first-page":"28","article-title":"The generalization of \u2018student\u2019s\u2019 problem when several different population variances are involved","volume":"34","author":"Welch","year":"1947","journal-title":"Biometrica"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0022-3476(43)80022-6","article-title":"Menarcheal age and the height, weight, and skeletal age of girls age 7 to 17 years","volume":"22","author":"Simmons","year":"1943","journal-title":"J. Pediatr."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/7\/861\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:52:28Z","timestamp":1782820348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/7\/861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["children13070861"],"URL":"https:\/\/doi.org\/10.3390\/children13070861","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}