{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:14:30Z","timestamp":1783617270064,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in early childhood and substantially impairs quality of life. Patient-Oriented Eczema Measure (POEM) is a validated patient-reported outcome, whereas SCORing Atopic Dermatitis (SCORAD) is a widely used clinician-assessed severity index for AD. Methods: In this single-center observational analytical pilot study, 90 pediatric patients (1 month\u201315 years) diagnosed with AD, according to Hanifin and Rajka criteria, were recruited at Saint Constantin Hospital, Bra\u0219ov, Romania (September 2025\u2013February 2026). During one visit, caregivers and\/or children completed the Romanian version of the POEM, and a dermatologist assessed disease severity using SCORAD. Demographic and clinical data were recorded. Descriptive statistics, group comparisons, linear regression, and correlation analyses (Pearson\/Spearman) were performed (significance p &lt; 0.05). The main objectives of the study were to translate and adapt the POEM questionnaire into Romanian for use in children with AD and to assess the relationship between POEM and SCORAD scores. Secondary objectives were to explore the influence of clinical and perinatal factors (sex, prematurity, mode of delivery, in vitro fertilization, breastfeeding) and the presence of other atopic diseases on AD severity. Results: POEM and SCORAD scores showed a strong positive correlation (rho = 0.841, p &lt; 0.001), indicating that patient-reported symptom burden closely paralleled clinician-assessed disease severity. The presence of another atopic condition was independently associated with higher POEM (B = 4.31, p &lt; 0.001) and SCORAD scores (B = 15.34, p &lt; 0.001). No other demographic or perinatal factor showed a consistent independent association with disease severity. No significant independent associations were found for sex, age, prematurity, in vitro fertilization, or breastfeeding. Conclusions: This first Romanian pilot study in pediatric AD demonstrates a strong correlation between POEM and SCORAD and supports the concurrent use of POEM as a practical patient-reported tool alongside SCORAD in clinical practice, while recognizing the limitations of a relatively small cohort and single-visit design.<\/jats:p>","DOI":"10.3390\/children13070905","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:16:44Z","timestamp":1783613804000},"page":"905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot Study Regarding Translation of Patient-Oriented Eczema Measure Questionnaire in Romanian Language in Assessing the Correlation Between Quality of Life and Disease Severity in Children with Atopic Dermatitis"],"prefix":"10.3390","volume":"13","author":[{"given":"Raluca-Gabriela","family":"Miulescu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"Dermatology Department, Saint Constantin Hospital, 500388 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4629-5820","authenticated-orcid":false,"given":"Ioana","family":"Ro\u0219ca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cProf. Dr. P.Sirbu\u201d, 060251 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-4754","authenticated-orcid":false,"given":"Alexandru-Neculai","family":"Pavel","sequence":"additional","affiliation":[{"name":"Pax Clinic, 020951 Bucharest, Romania"},{"name":"FutureMeds, 800001 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-1683","authenticated-orcid":false,"given":"Ruxandra-Cristina","family":"Marin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-8293","authenticated-orcid":false,"given":"Andreea Teodora","family":"Constantin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"Pediatrics Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 20382 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florica","family":"Sandru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"Dermatology Department, Elias University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-0841","authenticated-orcid":false,"given":"Elena","family":"Poenaru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Eugenia","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-Gynecology and Neonatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-2839","authenticated-orcid":false,"given":"Oana Andreia","family":"Coman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jaad.2016.05.028","article-title":"Persistence of atopic dermatitis (AD): A systematic review and meta-analysis","volume":"75","author":"Kim","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8561(03)00066-3","article-title":"Epidemiology of atopic dermatitis","volume":"22","author":"Larsen","year":"2002","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1067\/mjd.2000.107773","article-title":"The prevalence of atopic dermatitis in Oregon schoolchildren","volume":"43","author":"Laughter","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1824-7288-37-59","article-title":"Quality of life measures in Italian children with atopic dermatitis and their families","volume":"37","author":"Monti","year":"2011","journal-title":"Ital. J. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3892\/etm.2020.9319","article-title":"Correlation between quality of life and disease severity of pediatric patients with atopic dermatitis","volume":"20","author":"Sur","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"adv00737","DOI":"10.2340\/actadv.v102.575","article-title":"Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children","volume":"102","author":"Gerner","year":"2022","journal-title":"Acta Derm. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1016\/j.jaci.2003.09.033","article-title":"Atopic dermatitis and the atopic march","volume":"112","author":"Spergel","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_9","first-page":"93","article-title":"Atopic dermatitis and psychosocial comorbidities","volume":"18","author":"Kage","year":"2020","journal-title":"J. Der Dtsch. Dermatol. Ges."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.4081\/dr.2023.9689","article-title":"Translation and validation of patient-oriented eczema measure in the Greek language","volume":"16","author":"Stefanou","year":"2023","journal-title":"Dermatol. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1007\/s00431-024-05747-5","article-title":"Association between preterm birth and asthma and atopic dermatitis in preschool children: A nationwide population-based study","volume":"183","author":"Cha","year":"2024","journal-title":"Eur. J. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/bjd.12581","article-title":"Lower risk of atopic dermatitis among infants born extremely preterm compared with higher gestational age","volume":"169","author":"Barbarot","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/pai.12170","article-title":"The association of preterm birth with severe asthma and atopic dermatitis: A national cohort study","volume":"24","author":"Wilcox","year":"2013","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/pai.12560","article-title":"Neonatal risk factors of atopic dermatitis in Denmark\u2014Results from a nationwide register-based study","volume":"27","author":"Egeberg","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/adc.2008.142869","article-title":"Atopic dermatitis in premature and term children","volume":"94","author":"Kvenshagen","year":"2009","journal-title":"Arch. Dis. Child."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpeds.2009.06.063","article-title":"Intestinal microbial ecology in premature infants assessed with non-culture-based techniques","volume":"156","author":"Mshvildadze","year":"2010","journal-title":"J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"DiGiulio, D.B., Romero, R., Amogan, H.P., Kusanovic, J.P., Bik, E.M., Gotsch, F., Kim, C.J., Erez, O., Edwin, S., and Relman, D.A. (2008). Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: A molecular and culture-based investigation. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003056"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1399-3038.2006.00502.x","article-title":"Atopic dermatitis: Quality of life of young Italian children and their families and correlation with severity score","volume":"18","author":"Ricci","year":"2007","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/bjd\/ljad449","article-title":"Burden of atopic dermatitis in paediatric patients: An international cross-sectional study","volume":"190","author":"Weidinger","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kisieliene, I., Mainelis, A., Rudzeviciene, O., Bylaite-Bucinskiene, M., and Wollenberg, A. (2024). The Burden of Pediatric Atopic Dermatitis: Quality of Life of Patients and Their Families. J. Clin. Med., 13.","DOI":"10.3390\/jcm13061700"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/pde.15399","article-title":"The disease burden of pediatric patients with atopic dermatitis in Japan","volume":"40","author":"Ohya","year":"2023","journal-title":"Pediatr. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5114\/ada.2023.128999","article-title":"Atopic dermatitis and gestational age\u2014Is there an association between them? A review of the literature and an analysis of pathology","volume":"40","author":"Kowalik","year":"2023","journal-title":"Adv. Dermatol. Allergol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/7\/905\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:34:17Z","timestamp":1783614857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/7\/905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":23,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["children13070905"],"URL":"https:\/\/doi.org\/10.3390\/children13070905","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]}}}