{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:05:05Z","timestamp":1784653505907,"version":"3.55.0"},"reference-count":22,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Vaccinations are a cornerstone of primary prevention in pediatric otolaryngology and play a critical role in reducing the burden of pediatric infectious diseases, particularly acute otitis media (AOM) and HPV-related infections. The introduction and widespread use of pneumococcal conjugate vaccines (PCVs) have been associated with substantial changes in the epidemiology of pediatric AOM, particularly through reductions in vac-cine-serotype disease and complicated forms, while contributing to changes in pathogen distribution with an increased role of non-vaccine serotypes and non-pneumococcal bac-teria, requiring continuous epidemiological surveillance. Prophylactic human papillomavirus (HPV) vaccination in adolescents and young adults effectively prevents oral infection with vaccine-type high-risk HPV, a necessary step in the pathogenesis of HPV-related oropharyngeal carcinoma. Clinical and epidemiological studies demonstrate robust antibody responses and significant reductions in oral HPV prevalence among vaccinated individuals. Although direct evidence of a reduction in oropharyngeal cancer incidence is not yet available, vaccination may consequently reduce the future burden of HPV-related oropharyngeal cancers. Long-term surveillance remains essential to confirm this potential benefit. Barriers to optimal vaccine coverage include unequal access, incomplete vaccination uptake, and limited awareness of HPV-related oral disease. In conclusion, vaccinations provide direct and clinically relevant benefits in pediatric otolaryngology by reducing recurrent AOM, severe complications and surgical interventions. HPV vaccination also reduces vaccine-type oral HPV infection and may consequently contribute to reducing the future burden of HPV-related oropharyngeal cancers. Achieving high vaccination coverage, coupled with continuous epidemiological monitoring, is essential to maximize individual and public health benefits and to inform the development of vaccines with broader serotype coverage.<\/jats:p>","DOI":"10.3390\/children13070958","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:16:39Z","timestamp":1784650599000},"page":"958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Pneumococcal and Human Papillomavirus Vaccination in Preventing Otolaryngological Diseases: Implications for Pediatric Practice"],"prefix":"10.3390","volume":"13","author":[{"given":"Carla","family":"Ungaro","sequence":"first","affiliation":[{"name":"U.O.S.D. Coordination of Clinical Activities in Childhood Obesity, ASL Napoli 1 Centro, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Oliva","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, \u201cA. Cardarelli\u201d Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ricciardiello","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Abate","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, \u201cA. Cardarelli\u201d Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Tesorone","sequence":"additional","affiliation":[{"name":"U.O.C. Protection of Women, Child and Adolescent\u2019s Health, Local Health Unit, ASL Napoli 1 Centro, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1007\/s00405-025-09461-2","article-title":"Global burden and prevalence of otitis media-induced hearing loss in children: 32-year study","volume":"282","author":"Jin","year":"2025","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Maltseva, M., Klasen, C., Wuerdemann, N., Hannich, M., Klussmann, J.P., and Wieland, U. (2025). Detection and natural history of HPV infection of oral cavity and tonsils\u2014A systematic literature review. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-14547-5"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/cid\/cis292","article-title":"Impact of pneumococcal conjugate vaccination on otitis media: A systematic review","volume":"54","author":"Taylor","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2013693","DOI":"10.1080\/21645515.2021.2013693","article-title":"Systematic review of the efficacy, effectiveness and impact of high-valency pneumococcal conjugate vaccines on otitis media","volume":"18","author":"Izurieta","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/cid\/ciab066","article-title":"Effectiveness of the 7- and 13-Valent Pneumococcal Conjugate Vaccines Against Vaccine-Serotype Otitis Media","volume":"73","author":"Dagan","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jpeds.2021.04.025","article-title":"Pneumococcal Conjugated Vaccines Decreased Acute Otitis Media Burden: A Population-Based Study in Israel","volume":"235","author":"Marom","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_7","first-page":"CD001480","article-title":"Pneumococcal conjugate vaccines for preventing acute otitis media in children","volume":"11","author":"Venekamp","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/infdis\/jiaf154","article-title":"Eighteen-Year Longitudinal Study of Uncomplicated and Complex Acute Otitis Media During the Pneumococcal Conjugate Vaccine Era, 2006\u20132023","volume":"232","author":"Fuji","year":"2025","journal-title":"J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ohn.327","article-title":"Efficacy of Pneumococcal Vaccine on Otitis Media: A Systematic Review and Meta-Analysis","volume":"169","author":"Wannarong","year":"2023","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1093\/infdis\/jiaf376","article-title":"Pneumococcal Serotype Distribution and Coverage of Existing and Pipeline Pneumococcal Vaccines","volume":"232","author":"King","year":"2025","journal-title":"J. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/INF.0000000000004413","article-title":"Anticipated Effects of Higher-valency Pneumococcal Conjugate Vaccines on Colonization and Acute Otitis Media","volume":"43","author":"Kaur","year":"2024","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Tzovara, I., Doudoulakakis, A., Kalogeras, G., Koutouzis, E., Dellis, C., Pasparakis, S., Charakida, M., Lebessi, E., Bozavoutoglou, E., and Tsakanikos, M. (2025). Bacterial Acute Otitis Media Complicated with Otorrhea in a Children\u2019s Hospital in the Era of Pneumococcal Conjugate Vaccines. Pathogens, 14.","DOI":"10.3390\/pathogens14050494"},{"key":"ref_13","unstructured":"Centers for Disease Control and Prevention (CDC) (2026, March 15). Pneumococcal Vaccine Recommendations. National Center for Immunization and Respiratory Diseases. Updated 25 February 2026, Available online: https:\/\/www.cdc.gov\/pneumococcal\/hcp\/vaccine-recommendations\/index.html."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/ijc.28811","article-title":"High-risk HPV types and head and neck cancer","volume":"135","author":"Michaud","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_15","first-page":"4","article-title":"Human Papillomavirus-Related Oropharyngeal Carcinoma: Update on Etiology, Management and the Role of Oral Health Care Providers","volume":"91","author":"Samim","year":"2025","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2486768","DOI":"10.1080\/21645515.2025.2486768","article-title":"Human papillomavirus (HPV) related oropharyngeal cancers in Canada: A multicenter retrospective cohort study","volume":"21","author":"Racovitan","year":"2025","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_17","unstructured":"Centers for Disease Control and Prevention (CDC) (2026, March 15). Chapter 11: Human Papillomavirus. In: Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book). Updated 23 April 2024, Available online: https:\/\/www.cdc.gov\/pinkbook\/hcp\/table-of-contents\/chapter-11-human-papillomavirus.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1056\/NEJMoa2506765","article-title":"Noninferiority of One HPV Vaccine Dose to Two Doses","volume":"393","author":"Kreimer","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2497608","DOI":"10.1080\/21645515.2025.2497608","article-title":"Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review","volume":"21","author":"Harper","year":"2025","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Herrer, R., Quint, W., Hildesheim, A., Gonzalez, P., Struijk, L., Katki, H.A., Porras, C., Schiffman, M., Rodriguez, A.C., and Solomon, D. (2013). Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068329"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/OLQ.0000000000001405","article-title":"Human Papillomavirus Vaccine to End Oropharyngeal Cancer. A Systematic Review and Meta-Analysis","volume":"48","author":"Tsentemeidou","year":"2021","journal-title":"Sex. Transm. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mart\u00edn, E., Reina, G., and Carlos, S. (2025). Advances in Therapeutic Vaccines Against HPV: A Review of Human Clinical Trials. Curr. Oncol., 32.","DOI":"10.3390\/curroncol32110600"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/7\/958\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:32:31Z","timestamp":1784651551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/7\/958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["children13070958"],"URL":"https:\/\/doi.org\/10.3390\/children13070958","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}