{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:51:17Z","timestamp":1790985077946,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Pediatric mild-to-moderate burns require careful management in the early phase, yet evidence guiding optimal initial dressing selection remains limited. Although topical medications and specialized dressings are routinely used, a universally accepted standard of care is lacking. Methods: We conducted a 1-year, real-world, retrospective, comparative, single-center study evaluating whether treatment with enzyme alginogel (Flaminal\u00ae) or NaOCl 0.05% antiseptic in the first 24 h led to different outcomes in terms of healing time, lesion progression, complication occurrence, scar quality, and burden of care. Medical records of 80 children with mild-to-moderate burns (Total Body Surface Area &lt; 15%) treated between January and December 2024 were analyzed. Results: Despite a higher proportion of deep burns, early treatment with enzyme alginogel was associated with a 6.17-day [95% Confidence Interval: 4.71\u20137.63 days] shorter healing time (p &lt; 0.001), with no observed lesion worsening or need for early surgery. The complication rate was 14% in the enzyme alginogel group, while all patients receiving antiseptic dressing had at least one complication (p &lt; 0.001). Patients treated with enzyme alginogel also showed better Vancouver Scar Score [2.95 points, 95% Confidence Interval: 2.33\u20133.23, p &lt; 0.001] and fewer follow-up visits, supporting a direct relationship between healing time and scar outcomes, and suggesting a potential reduction in the burden of care. Conclusions: Early management with alginogel favored healing, reduced complications, improved scar outcomes, and reduced burden of care in comparison to the initial treatment with NaOCl-based antiseptic dressings followed by treatment change when clinically indicated. Prospective, comparative, randomized studies are needed to confirm these findings.<\/jats:p>","DOI":"10.3390\/children13080994","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:16:34Z","timestamp":1785172594000},"page":"994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Enzyme-Alginogel Treatment Improves Healing and Reduces Complications, Scarring, and Healthcare Burden in Children with Mild-to-Moderate Burns: A Retrospective Real-World Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6665-1638","authenticated-orcid":false,"given":"Biagio","family":"Nicolosi","sequence":"first","affiliation":[{"name":"Health Professions Department, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"},{"name":"AISLeC, Italian Nursing Association of Wound Care, 47923 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-8948","authenticated-orcid":false,"given":"Emanuele","family":"Buccione","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Local Health Authority 3 of Pescara, 65124 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0559-5264","authenticated-orcid":false,"given":"Hamilton","family":"Dollaku","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, IRCCS Don Gnocchi Hospital, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0229-2173","authenticated-orcid":false,"given":"Benedetta Virginia","family":"Difalco","sequence":"additional","affiliation":[{"name":"Health Professions Department, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Salutini","sequence":"additional","affiliation":[{"name":"Health Professions Department, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Martin","sequence":"additional","affiliation":[{"name":"Simple Departmental Organizational Structure of Plastic Surgery and Burn Center, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Certini","sequence":"additional","affiliation":[{"name":"Simple Departmental Organizational Structure of Plastic Surgery and Burn Center, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Bachelor\u2019s Degree Program in Nursing, School of Human Health Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Spano","sequence":"additional","affiliation":[{"name":"Bachelor\u2019s Degree Program in Nursing, School of Human Health Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Castiello","sequence":"additional","affiliation":[{"name":"AISLeC, Italian Nursing Association of Wound Care, 47923 Rimini, Italy"},{"name":"Cardiovascular Area and Adult & Pediatric Intensive Care, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Facchini","sequence":"additional","affiliation":[{"name":"Simple Departmental Organizational Structure of Plastic Surgery and Burn Center, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ciprandi","sequence":"additional","affiliation":[{"name":"Complex Unit of Plastic Surgery, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","first-page":"e49012","article-title":"Pediatric Burns: A Systematic Review and Meta-Analysis on Epidemiology, Gender Distribution, Risk Factors, Management, and Outcomes in Emergency Departments","volume":"15","author":"Nassar","year":"2023","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pelizzo, G., Calcaterra, V., Canonica, C.P.M., Magenes, V.C., Marinaro, M., Durante, E., Cordaro, E., and Zuccotti, G. 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