{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:44:25Z","timestamp":1785836665205,"version":"3.56.0"},"reference-count":70,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Preeclampsia (PE) may be associated with maternal endothelial activation and altered early neonatal inflammation. The primary objective was to compare maternal and early neonatal serum interleukin 2 (IL2), IL6, IL8, tumor necrosis factor \u03b1 (TNF\u03b1), and endothelin 1 (ET1) concentrations between PE and control mother\u2013neonate pairs. Methods: This secondary report from a single-center observational cohort included 31 women with PE (34 neonates) and 45 control women (47 neonates). Biomarker concentrations were log-transformed, and PE\u2013control differences were estimated using linear models, with results expressed as geometric mean ratios (GMRs). Neonatal models used pregnancy-clustered standard errors to account for twins. The Benjamini\u2013Hochberg procedure was applied to control the false discovery rate (FDR). Additional neonatal models adjusted for gestational age at birth served as sensitivity analyses. Selected biomarker\u2013outcome associations were explored post hoc using univariable Firth bias-reduced logistic regression. Results: Maternal ET1 was higher in PE (GMR = 1.79, 95% confidence interval\u2014CI\u20141.53\u20132.09; q &lt; 0.001). Neonatal IL2 (GMR = 1.37, 95% CI 1.11\u20131.71; q = 0.016) and TNF\u03b1 (GMR = 1.49, 95% CI 1.22\u20131.82; q &lt; 0.001) were higher in PE-exposed neonates. After gestational age at birth adjustment, the TNF\u03b1 difference persisted (GMR = 1.33, 95% CI 1.14\u20131.55; q = 0.003), whereas IL2 was attenuated (GMR = 1.20, 95% CI 0.99\u20131.45; q = 0.164). None of the exploratory Firth associations remained significant after FDR correction. Thrombocytopenia at birth occurred in 5\/33 PE-exposed and 1\/47 control neonates; intraventricular hemorrhage occurred in 2\/34 and 2\/47, respectively. Conclusions: PE was associated with between-group differences in maternal endothelial and early neonatal inflammatory biomarkers, with maternal ET1 and neonatal TNF\u03b1 as the most robust signals. Complication-related findings remain hypothesis-generating and do not support predictive cut-offs, risk stratification, or causal inference.<\/jats:p>","DOI":"10.3390\/children13081039","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:02:19Z","timestamp":1785830539000},"page":"1039","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and Early Neonatal Serum Cytokine and Endothelin-1 Concentrations in Preeclampsia: A Single-Center Observational Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Christos-Georgios","family":"Kontovazainitis","sequence":"first","affiliation":[{"name":"2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), \u201cPapageorgiou\u201d University Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Gialamprinou","sequence":"additional","affiliation":[{"name":"2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), \u201cPapageorgiou\u201d University Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Fleva","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department, \u201cPapageorgiou\u201d University Hospital, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Giannakou","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department, \u201cPapageorgiou\u201d University Hospital, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Elina","family":"Bessina","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department, \u201cPapageorgiou\u201d University Hospital, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Varsami","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department, \u201cPapageorgiou\u201d University Hospital, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-2215","authenticated-orcid":false,"given":"Theodoros","family":"Theodoridis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u201cPapageorgiou\u201d University Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mitsiakou","sequence":"additional","affiliation":[{"name":"2nd Department of Paediatrics, \u201cAHEPA\u201d University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet","family":"Diamanti","sequence":"additional","affiliation":[{"name":"2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), \u201cPapageorgiou\u201d University Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-1614","authenticated-orcid":false,"given":"Georgios","family":"Mitsiakos","sequence":"additional","affiliation":[{"name":"2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), \u201cPapageorgiou\u201d University Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1080\/14767058.2017.1401996","article-title":"How Does Preeclampsia Affect Neonates? Highlights in the Disease\u2019s Immunity","volume":"32","author":"Marins","year":"2019","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"214365","DOI":"10.1155\/2011\/214365","article-title":"Maternal Preeclampsia and Neonatal Outcomes","volume":"2011","author":"Backes","year":"2011","journal-title":"J. Pregnancy"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Koulouraki, S., Paschos, V., Pervanidou, P., Christopoulos, P., Gerede, A., and Eleftheriades, M. (2023). Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature. Children, 10.","DOI":"10.3390\/children10050826"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.preghy.2018.11.001","article-title":"Preeclampsia and Risk of Developing Bronchopulmonary Dysplasia in Very Preterm Neonates","volume":"15","author":"Wilmink","year":"2019","journal-title":"Pregnancy Hypertens."},{"key":"ref_5","unstructured":"Taylor, R.N. (2015). Chesley\u2019s Hypertensive Disorders in Pregnancy, AP. [4th ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational Hypertension and Preeclampsia","volume":"135","author":"Espinoza","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/01.AOG.0000178750.84837.ed","article-title":"Transfer of Proinflammatory Cytokines Across Term Placenta","volume":"106","author":"Aaltonen","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/01.AOG.0000114980.40445.83","article-title":"Transfer of Inflammatory Cytokines Across the Placenta","volume":"103","author":"Zaretsky","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9378(96)70045-5","article-title":"Evidence of Endothelial Activation and Endothelial Activators in Cord Blood of Infants of Preeclamptic Women","volume":"175","author":"Davidge","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000047118","article-title":"Inflammatory Mediators in Umbilical Plasma from Neonates Who Develop Early-Onset Sepsis","volume":"80","author":"Vatten","year":"2001","journal-title":"Neonatology"},{"key":"ref_11","first-page":"269681","article-title":"Neonatal Sepsis and Inflammatory Mediators","volume":"2014","author":"Soave","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jpids\/piu063","article-title":"Effective Biomarkers for Diagnosis of Neonatal Sepsis","volume":"3","author":"Bhandari","year":"2014","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Vasilescu, D.I., Dan, A.M., Dragomir, I., Vasilescu, S.L., Dumitru, A.V., Dima, V., and C\u00eerstoiu, M.M. (2025). Predicting Neonatal Morbidity and Correlations with Maternal and Neonatal Biomarkers in Connection with Fetal Inflammatory Response Syndrome in Premature Births. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186440"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Prashant, A., Vishwanath, P., Kulkarni, P., Sathya Narayana, P., Gowdara, V., Nataraj, S.M., and Nagaraj, R. (2013). Comparative Assessment of Cytokines and Other Inflammatory Markers for the Early Diagnosis of Neonatal Sepsis\u2013A Case Control Study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068426"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.pedneo.2017.10.004","article-title":"Evaluate the Diagnosis of Neonatal Sepsis by Measuring Interleukins: A Systematic Review","volume":"59","author":"Boskabadi","year":"2018","journal-title":"Pediatr. Neonatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000089180","article-title":"Elevation of Cytokine Concentrations in Asphyxiated Neonates","volume":"89","author":"Okazaki","year":"2006","journal-title":"Neonatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1651-2227.2001.tb03250.x","article-title":"Cord Blood Levels of Cytokines as Predictors of Early Neonatal Sepsis","volume":"90","author":"Santana","year":"2001","journal-title":"Acta Paediatr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kontovazainitis, C.-G., Gialamprinou, D., Fleva, A., Theodoridis, T., Chatziioannidis, I., Mitsiakou, C., Banti, A., Diamanti, E., and Mitsiakos, G. (2025). Rotational Thromboelastometry (ROTEM) Hemostasis Profile in Pregnant Women with Preeclampsia and Their Offspring: An Observational Study. Diagnostics, 15.","DOI":"10.3390\/diagnostics15172156"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1097\/AOG.0000000000003020","article-title":"ACOG Practice Bulletin No. 203: Chronic Hypertension in Pregnancy","volume":"133","author":"Vidaeff","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_20","unstructured":"NICE Guideline (2022, August 18). Hypertension in Pregnancy: Diagnosis and Management. Available online: https:\/\/www.nice.org.uk\/guidance\/ng133\/resources\/hypertension-in-pregnancy-diagnosis-and-management-pdf-66141717671365."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/HYPERTENSIONAHA.108.117358","article-title":"Early and Late Preeclampsia: Two Different Maternal Hemodynamic States in the Latent Phase of the Disease","volume":"52","author":"Valensise","year":"2008","journal-title":"Hypertension"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/aogs.13846","article-title":"Validation of the 34-week Gestation as Definition of Late Onset Preeclampsia: Testing Different Cutoffs from 30 to 37 Weeks on a Population-based Cohort of 1700 Preeclamptics","volume":"99","author":"Robillard","year":"2020","journal-title":"Acta Obs. Gynecol. Scand."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.siny.2015.11.001","article-title":"Thrombocytopenia and Platelet Transfusion in the Neonate","volume":"21","author":"Cremer","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/jp.2008.141","article-title":"Platelet Reference Ranges for Neonates, Defined Using Data from over 47,000 Patients in a Multihospital Healthcare System","volume":"29","author":"Wiedmeier","year":"2009","journal-title":"J. Perinatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jpeds.2018.01.043","article-title":"Bronchopulmonary Dysplasia: Executive Summary of a Workshop","volume":"197","author":"Higgins","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and Evolution of Subependymal and Intraventricular Hemorrhage: A Study of Infants with Birth Weights Less than 1,500 Gm","volume":"92","author":"Papile","year":"1978","journal-title":"J. Pediatr."},{"key":"ref_27","unstructured":"Volpe, J.J. (2018). Preterm Intraventricular Hemorrhage\/Posthemorrhagic Hydrocephalus. Volpe\u2019s Neurology of the Newborn, Elsevier."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2020029082","DOI":"10.1542\/peds.2020-029082","article-title":"Routine Neuroimaging of the Preterm Brain","volume":"146","author":"Hand","year":"2020","journal-title":"Pediatrics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jpeds.2019.05.032","article-title":"Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes","volume":"212","author":"Caplan","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0031-3955(16)34975-6","article-title":"Necrotizing Enterocolitis: Treatment Based on Staging Criteria","volume":"33","author":"Walsh","year":"1986","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ophtha.2021.05.031","article-title":"International Classification of Retinopathy of Prematurity, Third Edition","volume":"128","author":"Chiang","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e20183061","DOI":"10.1542\/peds.2018-3061","article-title":"Screening Examination of Premature Infants for Retinopathy of Prematurity","volume":"142","author":"Fierson","year":"2018","journal-title":"Pediatrics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000528914","article-title":"European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update","volume":"120","author":"Sweet","year":"2023","journal-title":"Neonatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e22834","DOI":"10.1002\/jcla.22834","article-title":"Association of Pro- and Anti-Inflammatory Cytokines in Preeclampsia","volume":"33","author":"Aggarwal","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00404-015-3803-1","article-title":"Serum Levels of ET-1, M30, and Angiopoietins-1 and -2 in HELLP Syndrome and Preeclampsia Compared to Controls","volume":"293","author":"Karakus","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-0030-1263295","article-title":"Endothelin-1 and L-Arginine in Preterm Infants with Respiratory Distress","volume":"28","author":"Sherif","year":"2011","journal-title":"Am. J. Perinatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/sim.4780140810","article-title":"The Log Transformation Is Special","volume":"14","author":"Keene","year":"1995","journal-title":"Stat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Stat. Methodol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","article-title":"Bias Reduction of Maximum Likelihood Estimates","volume":"80","author":"Firth","year":"1993","journal-title":"Biometrika"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/sim.1047","article-title":"A Solution to the Problem of Separation in Logistic Regression","volume":"21","author":"Heinze","year":"2002","journal-title":"Stat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000052943","article-title":"Differential Levels of Interleukin 6 in Maternal and Cord Sera and Placenta in Women with Pre-Eclampsia","volume":"52","author":"Omu","year":"2001","journal-title":"Gynecol. Obs. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/14767051003774942","article-title":"Maternal and Umbilical Serum Levels of Interleukin-6, Interleukin-8, and Tumor Necrosis Factor-\u03b1 in Normal Pregnancies and in Pregnancies Complicated by Preeclampsia","volume":"23","author":"Tosun","year":"2010","journal-title":"J. Matern. -Fetal Neonatal Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jri.2015.09.003","article-title":"Preeclampsia Is Associated with an Increased Pro-Inflammatory Profile in Newborns","volume":"112","author":"Guillemette","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1055\/a-2764-2369","article-title":"Associated Factors Relating to the Success of Labor Induction among Pregnant Women Diagnosed with Fetal Intrauterine Growth Restriction: A Retrospective Cohort Study from France","volume":"16","author":"Nguyen","year":"2026","journal-title":"AJP Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000065888","article-title":"The Thrombopoietin Level in the Cord Blood in Premature Infants Born to Mothers with Pregnancy-Induced Hypertension","volume":"82","author":"Tsao","year":"2002","journal-title":"Neonatology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7953289","DOI":"10.1155\/2020\/7953289","article-title":"Effect of Maternal Preeclampsia on Hematological Profile of Newborns in Qatar","volume":"2020","author":"Bayoumi","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12098-008-0110-x","article-title":"Neonatal Thrombocytopenia Associated with Maternal Pregnancy Induced Hypertension","volume":"75","author":"Cherian","year":"2008","journal-title":"Indian. J. Pediatr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"F359","DOI":"10.1136\/fn.88.5.F359","article-title":"Neonatal Thrombocytopenia: Causes and Management","volume":"88","author":"Roberts","year":"2003","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"049","DOI":"10.1055\/s-2003-37948","article-title":"Risk Factors for Neonatal Thrombocytopenia in Preterm Infants","volume":"20","author":"Beiner","year":"2003","journal-title":"Am. J. Perinatol."},{"key":"ref_50","first-page":"162","article-title":"Absent Umbilical Artery End-Diastolic Velocity in Growth-Restricted Fetuses: A Risk Factor for Neonatal Thrombocytopenia","volume":"96","author":"Baschat","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/jp.2008.104","article-title":"Hematologic Effects of Placental Pathology on Very Low Birthweight Infants Born to Mothers with Preeclampsia","volume":"29","author":"Zook","year":"2009","journal-title":"J. Perinatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary Dysplasia","volume":"163","author":"Jobe","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/MOP.0b013e328346577f","article-title":"Pathogenesis and Treatment of Bronchopulmonary Dysplasia","volume":"23","author":"Gien","year":"2011","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Dankhara, N., Holla, I., Ramarao, S., and Kalikkot Thekkeveedu, R. (2023). Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology. J. Clin. Med., 12.","DOI":"10.20944\/preprints202305.0591.v1"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12931-018-0787-y","article-title":"Effects and Molecular Mechanisms of Intrauterine Infection\/Inflammation on Lung Development","volume":"19","author":"Pan","year":"2018","journal-title":"Respir. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6648208","DOI":"10.1155\/2021\/6648208","article-title":"Cytokines and Exhaled Nitric Oxide Are Risk Factors in Preterm Infants for Bronchopulmonary Dysplasia","volume":"2021","author":"Zhang","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_57","first-page":"3101","article-title":"Loss of Interleukin-6 Enhances the Inflammatory Response Associated with Hyperoxia-induced Lung Injury in Neonatal Mice","volume":"17","author":"Li","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"L909","DOI":"10.1152\/ajplung.00367.2015","article-title":"Absence of TNF-\u03b1 Enhances Inflammatory Response in the Newborn Lung Undergoing Mechanical Ventilation","volume":"310","author":"Ehrhardt","year":"2016","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.21608\/ejhm.2022.247139","article-title":"Endothelin 1 as A Predictor Marker for Bronchopulmonary Dysplasia in Preterm Neonates with Respiratory Distress Syndrome","volume":"88","author":"Mohamed","year":"2022","journal-title":"Egypt. J. Hosp. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Rivera, L., Siddaiah, R., Oji-Mmuo, C., Silveyra, G.R., and Silveyra, P. (2016). Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant. Front. Pediatr., 4.","DOI":"10.3389\/fped.2016.00033"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.braindev.2004.12.003","article-title":"Umbilical Vein Interleukin-6 Levels in Very Low Birth Weight Infants Developing Intraventricular Hemorrhage","volume":"27","author":"Kassal","year":"2005","journal-title":"Brain Dev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"F501","DOI":"10.1136\/fn.88.6.F501","article-title":"Increased Serum Levels of Interleukin 6 Are Associated with Severe Intraventricular Haemorrhage in Extremely Premature Infants","volume":"88","author":"Heep","year":"2003","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/19345798251372547","article-title":"Cord Blood Cytokines as Early Predictors for Retinopathy of Prematurity","volume":"19","author":"Mohamad","year":"2026","journal-title":"J. Neonatal-Perinat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/ANC.0000000000000959","article-title":"Vagal Tone and Proinflammatory Cytokines Predict Feeding Intolerance and Necrotizing Enterocolitis Risk","volume":"21","author":"Meister","year":"2021","journal-title":"Adv. Neonatal Care"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1600-079X.2004.00124.x","article-title":"Early Indicators of Chronic Lung Disease in Preterm Infants with Respiratory Distress Syndrome and Their Inhibition by Melatonin","volume":"36","author":"Gitto","year":"2004","journal-title":"J. Pineal Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-2004-828610","article-title":"Oxidative and Inflammatory Parameters in Respiratory Distress Syndrome of Preterm Newborns: Beneficial Effects of Melatonin","volume":"21","author":"Gitto","year":"2004","journal-title":"Am. J. Perinatol."},{"key":"ref_67","first-page":"239","article-title":"Study of Plasma Endothelin-1 Concentrations in Taiwanese Neonates with Respiratory Distress","volume":"24","author":"Kuo","year":"2001","journal-title":"Chang Gung Med. J."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Vuong, A.D.B., Tran, N.H., Pham, T.H., Le, H.A.M., and Nguyen, P.N. (2025). Soluble Fibrin Monomer Complex and D-Dimer Concentrations Between Patients at Low and High Risk of Venous Thromboembolism Before Delivery According to RCOG Score Assessment: An Observational Study Among 100 Third-Trimester Vietnamese Pregnancies. J. Clin. Med., 14.","DOI":"10.3390\/jcm14051399"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2015.03.015","article-title":"Fetal and Early Neonatal Interleukin-6 Response","volume":"76","author":"Chiesa","year":"2015","journal-title":"Cytokine"},{"key":"ref_70","first-page":"541","article-title":"Conceptual and Methodological Issues Relevant to Cytokine and Inflammatory Marker Measurements in Clinical Research","volume":"13","author":"Zhou","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. 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