{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:18:42Z","timestamp":1788430722441,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["BR28713341"],"award-info":[{"award-number":["BR28713341"]}]},{"award":["BR28713341"],"award-info":[{"award-number":["BR28713341"]}],"id":[{"id":"https:\/\/ror.org\/05tyne317","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Remarkable advances in paediatric oncology over recent decades have transformed acute leukaemia and central nervous system (CNS) tumours from largely fatal diagnoses to conditions with survival rates exceeding 80% in many cases. This epidemiological success, however, has shifted the clinical and research focus toward survivorship and the long-term consequences of curative therapies. Health-related quality of life (HRQoL) has emerged as a critical outcome measure that captures the multidimensional impact of disease and treatment on children\u2019s physical, psychological, social, and educational functioning. This review synthesises current evidence on HRQoL in children with acute leukaemias, particularly acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), and CNS tumours, the two most common childhood malignancies. We examine measurement approaches, disease-specific HRQoL patterns, comparative outcomes between diagnostic groups, biopsychosocial determinants, and emerging interventions. The evidence consistently demonstrates that while ALL survivors generally experience HRQoL comparable to or slightly below population norms, children with CNS tumours face substantially greater and more persistent impairments across multiple domains. Treatment-related factors, particularly cranial irradiation, neurocognitive sequelae, family functioning, and socioeconomic status emerge as key determinants.<\/jats:p>","DOI":"10.3390\/children13091186","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:20:43Z","timestamp":1788427243000},"page":"1186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health-Related Quality of Life in Children with Acute Leukaemia and Central Nervous System Tumours: Current Evidence and Future Directions"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-3985","authenticated-orcid":false,"given":"Lyazat","family":"Manzhuova","sequence":"first","affiliation":[{"name":"Scientific Centre of Paediatrics and Paediatric Surgery, Al-Farabi Avenue 146, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-6363","authenticated-orcid":false,"given":"Timur","family":"Saliev","sequence":"additional","affiliation":[{"name":"Institute for Fundamental and Applied Medical Research, S.D. Asfendiyarov Kazakh National Medical University, Tole Bi Street 94, Almaty 050000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aigul","family":"Bazarbayeva","sequence":"additional","affiliation":[{"name":"Scientific Centre of Paediatrics and Paediatric Surgery, Al-Farabi Avenue 146, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"Kabakova","sequence":"additional","affiliation":[{"name":"Department of General and Applied Psychology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulzhan","family":"Kashaganova","sequence":"additional","affiliation":[{"name":"Department of Cybersecurity, Institute of Automation and Information Technologies, Satbayev University, Almaty 050013, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhan","family":"Kudaibergenova","sequence":"additional","affiliation":[{"name":"Department of General and Applied Psychology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-4246","authenticated-orcid":false,"given":"Zaure","family":"Dushimova","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medicine, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98000","DOI":"10.12998\/wjcc.v13.i7.98000","article-title":"Late effects of the treatment of childhood cancer","volume":"13","author":"Roganovic","year":"2025","journal-title":"World J. 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