{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:04:39Z","timestamp":1789643079802,"version":"4.0.0"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Mixed dentition is critical for identifying developing malocclusions that may benefit from preventive or interceptive orthodontic management. This study aimed to assess IPION-defined preventive\/interceptive orthodontic treatment need using the Index of Preventive and Interceptive Orthodontic Needs (IPION), compare early and late mixed dentition, and evaluate associated clinical findings. Methods: This single-center cross-sectional study included 200 children attending their first examination at the university Pediatric Dentistry and\/or Orthodontics clinics: 100 aged 6 and 100 aged 9 years. IPION-defined treatment need was assessed using the age-specific IPION-6 and IPION-9 subsystems. Dental, developmental, and occlusal findings were recorded using standardized criteria. Treatment-need categories and clinical findings common to both subsystems were compared between groups, while total IPION scores were summarized separately by age. Relationships of caries and premature primary tooth loss with IPION scores were evaluated. Results: Definite treatment need predominated (58.0% vs. 51.0%), and treatment-need distributions differed between age groups (p = 0.047). Dental caries, molar relationship, overjet, and overbite showed significant differences. In 6-year-olds, carious and prematurely lost tooth counts were positively correlated with IPION scores, with the strongest relationship for premature tooth loss (\u03c1 = 0.609; p &lt; 0.001). Relationships were weaker in 9-year-olds. Conclusions: IPION-defined preventive\/interceptive orthodontic treatment need was common within this university-based clinical sample across mixed dentition stages. Differences in treatment-need distribution and clinical findings indicated distinct preventive and interceptive orthodontic profiles across mixed dentition stages. Age-specific IPION assessment may support identification of children who may benefit from further orthodontic evaluation by integrating dental, developmental, and occlusal findings.<\/jats:p>","DOI":"10.3390\/children13091252","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:23:53Z","timestamp":1789496633000},"page":"1252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventive and Interceptive Orthodontic Treatment Needs in Early and Late Mixed Dentition: An IPION-Based Assessment in Children"],"prefix":"10.3390","volume":"13","author":[{"given":"Nuri Can","family":"Tanr\u0131sever","sequence":"first","affiliation":[{"name":"Department of Orthodontics, School of Dentistry, Ankara University, 06560 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-308X","authenticated-orcid":false,"given":"Tu\u011fba","family":"Bezgin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Ankara University, 06560 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-3411","authenticated-orcid":false,"given":"T\u00fclin Ufuk","family":"Toygar Memiko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry, Ankara University, 06560 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref_1","unstructured":"Proffit, W.R., Fields, H.W., Larson, B., and Sarver, D.M. (2019). Contemporary Orthodontics, Elsevier. [6th ed.]."},{"key":"ref_2","unstructured":"Bishara, S.E. (2001). Textbook of Orthodontics, Saunders."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0031-3955(05)70259-5","article-title":"Facial growth and management of orthodontic problems","volume":"47","author":"Vig","year":"2000","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0002-9416(69)90206-1","article-title":"The characteristics of malocclusion: A modern approach to classification and diagnosis","volume":"56","author":"Ackerman","year":"1969","journal-title":"Am. J. Orthod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1067\/mod.2002.124167","article-title":"Early intervention in the transverse dimension: Is it worth the effort?","volume":"121","author":"McNamara","year":"2002","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1067\/mod.2002.124173","article-title":"Early treatment of tooth-eruption disturbances","volume":"121","author":"Kurol","year":"2002","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tanr\u0131sever, N.C., and Ak\u00e7am, M.O. (2026). Sagittal, Vertical, and Transverse Skeletal Characteristics in Individuals with Impacted Maxillary Canines: A Retrospective Study. J. Clin. Med., 15.","DOI":"10.3390\/jcm15041466"},{"key":"ref_8","unstructured":"Graber, L.W., Vanarsdall, R.L., Vig, K.W., and Huang, G.J. (2016). Orthodontics: Current Principles and Techniques, Elsevier Health Sciences. [1st ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/adj.12474","article-title":"Timing orthodontic treatment: Early or late?","volume":"62","author":"Fleming","year":"2017","journal-title":"Aust. Dent. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000057774","article-title":"The role of prevention and simple interceptive measures in reducing the need for orthodontic treatment","volume":"11","author":"Kerosuo","year":"2002","journal-title":"Med. Princ. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ajodo.2008.02.023","article-title":"Effectiveness of interceptive orthodontic treatment in reducing malocclusions","volume":"137","author":"King","year":"2010","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pio.2011.06.001","article-title":"An insight into four orthodontic treatment need indices","volume":"12","year":"2011","journal-title":"Prog. Orthod."},{"key":"ref_13","unstructured":"Cons, N.C., Jenny, J., and Kohout, F.J. (1986). DAI: The Dental Aesthetic Index, College of Dentistry, University of Iowa."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/oxfordjournals.ejo.a035999","article-title":"The development of an index of orthodontic treatment priority","volume":"11","author":"Brook","year":"1989","journal-title":"Eur. J. Orthod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ortho\/27.2.149","article-title":"The development of the Index of Complexity, Outcome and Need (ICON)","volume":"27","author":"Daniels","year":"2000","journal-title":"J. Orthod."},{"key":"ref_16","first-page":"649","article-title":"Preventive and interceptive orthodontic treatment needs of an inner-city group of 6- and 9-year-old Canadian children","volume":"71","author":"Karaiskos","year":"2005","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_17","unstructured":"Coetzee, C.E., and de Muelenaere, K.R. (1997, January 5\u20137). Development of an index for preventive and interceptive orthodontic needs (IPION). Proceedings of the XXXI Scientific Session of the South African Division and XI Scientific Session of the East and Southern African Section, International Association for Dental Research, Cape Town, South Africa. Abstract 83."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.12688\/f1000research.133555.1","article-title":"Comparative evaluation of preventive and interceptive orthodontic treatment need in children aged 6, 9 and 12 years in Central India","volume":"12","author":"Nerurkar","year":"2023","journal-title":"F1000Research"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s40368-019-00453-5","article-title":"Orthodontic treatment needs of children with high caries using Index for Preventive and Interceptive Orthodontic Needs (IPION)","volume":"20","author":"Rapeepattana","year":"2019","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s44445-026-00181-9","article-title":"The Index for Preventive and Interceptive Orthodontic Treatment Needs (IPION): A scoping review","volume":"38","author":"Dino","year":"2026","journal-title":"Saudi Dent. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1038\/s41598-024-54381-6","article-title":"An epidemiological study on early orthodontic treatment need among eastern Saudi Arabian children in the mixed dentition stage","volume":"14","author":"Madiraju","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e8924","DOI":"10.7717\/peerj.8924","article-title":"Impact of proximal cavities and primary molar absence on space in the dental arches","volume":"8","author":"Gomide","year":"2020","journal-title":"PeerJ"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100816","DOI":"10.1016\/j.ortho.2023.100816","article-title":"Effect of premature loss of primary teeth on prevalence of malocclusion in permanent dentition: A systematic review and meta-analysis","volume":"21","author":"Shakti","year":"2023","journal-title":"Int. Orthod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.5005\/jp-journals-10005-2961","article-title":"Early orthodontic treatment needs of children in high caries population using index for preventive and interceptive orthodontic treatment needs","volume":"17","author":"Khan","year":"2024","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Tanr\u0131sever, N.C., Kartal, \u00d6.N., G\u00fcven\u00e7 Tokur, A.D., and Ak\u00e7am, M.O. (2026). Maxillary arch morphology in unilateral buccally and palatally impacted maxillary canines: A three-dimensional digital model study. Diagnostics, 16.","DOI":"10.3390\/diagnostics16131971"},{"key":"ref_26","first-page":"295","article-title":"Effects of premature loss of deciduous molars","volume":"54","author":"Northway","year":"1984","journal-title":"Angle Orthod."},{"key":"ref_27","first-page":"297","article-title":"Dental arch space changes following premature loss of primary first molars: A systematic review","volume":"30","author":"Tunison","year":"2008","journal-title":"Pediatr. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhao, J., Jin, H., Li, X., and Qin, X. (2023). Dental arch spatial changes after premature loss of first primary molars: A systematic review and meta-analysis of split-mouth studies. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03111-x"},{"key":"ref_29","first-page":"41","article-title":"Orthodontic treatment needs in mixed dentition\u2014For children of 6 and 9 years old","volume":"8","author":"Rauten","year":"2016","journal-title":"Rom. J. Oral Rehabil."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/9\/1252\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:53:34Z","timestamp":1789642414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/9\/1252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["children13091252"],"URL":"https:\/\/doi.org\/10.3390\/children13091252","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]}}}