{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:03:38Z","timestamp":1790075018556,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The most common primary malignant liver tumor of childhood, hepatoblastoma has increased in incidence over the last 30 years, but little is still known about its pathogenesis. Discoveries in molecular biology provide clues but have yet to define targeted therapies. Disease-free survival varies according to stage, but is greater than 90% in favorable risk populations, in part due to improvements in chemotherapeutic regimens, surgical resection, and earlier referral to liver transplant centers. This article aims to highlight the principles of disease that guide current treatment algorithms. Surgical treatment, especially orthotopic liver transplantation, will also be emphasized in the context of the current Children\u2019s Oncology Group international study of pediatric liver cancer (AHEP-1531).<\/jats:p>","DOI":"10.3390\/children6010001","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T09:24:11Z","timestamp":1545384251000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Hepatoblastoma\u2014The Evolution of Biology, Surgery, and Transplantation"],"prefix":"10.3390","volume":"6","author":[{"given":"Irene","family":"Lim","sequence":"first","affiliation":[{"name":"Division of General and Thoracic Surgery, Cincinnati Children\u2019s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bondoc","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery, Cincinnati Children\u2019s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Geller","sequence":"additional","affiliation":[{"name":"Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Tiao","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery, Cincinnati Children\u2019s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kehm, R.D., Osypuk, T.L., Poynter, J.N., Vock, D.M., and Spector, L.G. 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