{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:23:29Z","timestamp":1768929809255,"version":"3.49.0"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Children"],"abstract":"<jats:p>Premature and full-term infants are at high risk of morbidities such as intraventricular hemorrhage or hypoxic-ischemic encephalopathy. The sickest infants at birth are the most likely to die and or develop intraventricular hemorrhage. Delayed cord clamping has been shown to reduce these morbidities, but is currently not provided to those infants that need immediate resuscitation. This review will discuss recently published and ongoing or planned clinical trials involving neonatal resuscitation while the newborn is still attached to the umbilical cord. We will discuss the implications on neonatal management and delivery room care should this method become standard practice. We will review previous and ongoing trials that provided respiratory support compared to no support. Lastly, we will discuss the implications of implementing routine resuscitation support outside of a research setting.<\/jats:p>","DOI":"10.3390\/children6040060","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:02:53Z","timestamp":1555930973000},"page":"60","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neonatal Resuscitation with an Intact Cord: Current and Ongoing Trials"],"prefix":"10.3390","volume":"6","author":[{"given":"Anup C.","family":"Katheria","sequence":"first","affiliation":[{"name":"Sharp Mary Birch Hospital for Women &amp; Newborns, San Diego, CA 92123, USA"},{"name":"School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1001\/jamapediatrics.2015.0358","article-title":"Effect of delayed cord clamping on neurodevelopment at 4 years of age: A randomized clinical trial","volume":"169","author":"Andersson","year":"2015","journal-title":"JAMA Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Tarnow-Mordi, W., Morris, J., Kirby, A., Robledo, K., Askie, L., Brown, R., Evans, N., Finlayson, S., Fogarty, M., and Gebski, V. (2017). Delayed versus immediate cord clamping in preterm infants. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa1711281"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2017.10.231","article-title":"Delayed vs early umbilical cord clamping for preterm infants: A systematic review and meta-analysis","volume":"218","author":"Fogarty","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(65)91025-1","article-title":"Relation of onset of respiration to placental transfusion","volume":"1","author":"Redmond","year":"1965","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bmj.2.5648.11","article-title":"Placental transfusion as an intrauterine phenomenon in deliveries complicated by foetal distress","volume":"2","author":"Philip","year":"1969","journal-title":"Br. Med. 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Perinatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resuscitation.2018.07.020","article-title":"Baby-directed umbilical cord clamping: A feasibility study","volume":"131","author":"Blank","year":"2018","journal-title":"Resuscitation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/archdischild-2018-314947","article-title":"Clinical aspects of incorporating cord clamping into stabilisation of preterm infants","volume":"103","author":"Knol","year":"2018","journal-title":"Arch. Dis. Child Fetal. Neonatal. Ed."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pratesi, S., Montano, S., Ghirardello, S., Mosca, F., Boni, L., Tofani, L., and Dani, C. (2018). Placental circulation intact trial (PCI-T)\u2014resuscitation with the placental circulation intact vs. Cord milking for very preterm infants: A feasibility study. Front. 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Pediatr."}],"updated-by":[{"DOI":"10.3390\/children6050071","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000}}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/6\/4\/60\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:36:39Z","timestamp":1754260599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/6\/4\/60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["children6040060"],"URL":"https:\/\/doi.org\/10.3390\/children6040060","relation":{"correction":[{"id-type":"doi","id":"10.3390\/children6050071","asserted-by":"object"}]},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]}}}