{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:25:44Z","timestamp":1781893544888,"version":"3.54.5"},"reference-count":10,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The concomitant occurrence of duodenal atresia (DA) and a choledochal cyst (CC) has rarely been reported. Knowledge of both the presentation and management of this rare co-occurrence is imperative in avoiding potential complications and sequelae, such as biliary metaplasia. Herein we describe a female infant born at 32 weeks gestational age who was diagnosed with duodenal atresia and annular pancreas postnatally, who had subsequent findings of malrotation and a choledochal cyst, as seen from contrast imaging. Uncomplicated repair of the DA and obstruction was performed at 4 days of life. She re-presented 2 years later with non-bloody, nonbilious emesis and was found to have elevated amylase, lipase and liver enzymes. Imaging revealed dilated intra-hepatic ducts, a distended gallbladder and a large choledochal cyst. She underwent a cholecystostomy tube placement followed by a definitive choledochal cyst excision with immediate improvement following surgery and full resolution of symptoms before discharge.<\/jats:p>","DOI":"10.3390\/children7080099","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T11:15:27Z","timestamp":1597749327000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unique Case of Congenital Duodenal Atresia and a Choledochal Cyst and the Hypothesis of Their Embryological Evolution"],"prefix":"10.3390","volume":"7","author":[{"given":"Brittany","family":"Downing","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ 85719, USA"},{"name":"Banner University Medical Center, Tucson, AZ 85719, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Y.","family":"Bader","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ 85719, USA"},{"name":"Banner University Medical Center, Tucson, AZ 85719, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank P.","family":"Morello","sequence":"additional","affiliation":[{"name":"Banner University Medical Center, Tucson, AZ 85719, USA"},{"name":"Department of Medical Imaging, College of Medicine, University of Arizona, Tucson, AZ 85719, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-6883","authenticated-orcid":false,"given":"Ranjit I.","family":"Kylat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ 85719, USA"},{"name":"Banner University Medical Center, Tucson, AZ 85719, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"ref_1","first-page":"19","article-title":"Managing neonatal bowel obstruction: clinical perspectives","volume":"8","author":"Desoky","year":"2018","journal-title":"Res. Rep. Neonatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11894-016-0490-4","article-title":"Small Bowel Congenital Anomalies: A Review and Update","volume":"18","author":"Morris","year":"2016","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0002-9610(67)90372-8","article-title":"Anatomy and embryology of congenital intrinsic obstruction of the duodenum","volume":"114","author":"Boyden","year":"1967","journal-title":"Am. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s005340050083","article-title":"Embryogenesis of pancreaticobiliary maljunction inferred from development of duodenal atresia","volume":"6","author":"Ando","year":"1999","journal-title":"J. Hepatobiliary Pancreat. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0022-3468(05)80364-1","article-title":"Congenital duodenal obstruction: A 32-year review","volume":"28","author":"Bailey","year":"1993","journal-title":"J. Pediatr. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00383-009-2462-3","article-title":"Choledochal cyst associated with duodenal atresia: case report and review of the literature","volume":"25","author":"Iwai","year":"2009","journal-title":"Pediatr. Surg. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e231021","DOI":"10.1136\/bcr-2019-231021","article-title":"Congenital or acquired? Obstructive jaundice in reoperated duodenal atresia","volume":"12","author":"Goh","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/01.MPG.0000148773.80213.03","article-title":"Is there an association between duodenal atresia and choledochal cyst?","volume":"40","author":"Shih","year":"2005","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00383-002-0783-6","article-title":"Choledochal cyst and duodenal atresia: A rare combination of malformations","volume":"20","author":"Sugimoto","year":"2004","journal-title":"Pediatr. Surg. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1053\/jpsu.2000.8768","article-title":"Choledochal cyst associated with duodenal obstruction","volume":"35","author":"Komuro","year":"2000","journal-title":"J. Pediatr. Surg."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/7\/8\/99\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:02:21Z","timestamp":1760176941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/7\/8\/99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["children7080099"],"URL":"https:\/\/doi.org\/10.3390\/children7080099","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]}}}