{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:20:32Z","timestamp":1773458432253,"version":"3.50.1"},"reference-count":21,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Cognitive and acquired neurodevelopmental deficits have been reported in children with opsoclonus\u2013myoclonus syndrome (OMS) and are known to be associated with more severe and relapsing disease course. However, there is a paucity of data regarding cognitive dysfunction in children with stable neurological disease. We report three children with OMS and evolving cognitive dysfunction in the context of a mild disease course. The children\u2019s ages at disease onset were between 17 and 35 months and they were followed up for 4\u201310 years. Neuroblastoma was identified in one child. OMS severity scores ranged between 8 and 12\/15 at presentation. They underwent immunotherapy and all were in remission by 7 months (range 4\u201313 months), with treatment maintained for 1 year. One child remained relapse-free, while two others had one clinical relapse each and were immunotherapy-responsive again. In all cases, evolving cognitive dysfunction was reported despite being in remission and stable off treatment for a median of 20 months (range of 12\u201331 months; two OMS scores of 0\/15 and one of 2\/15). In children with OMS who have completed treatment and have made full or near full neurological recovery, concerns remain regarding long-term outcome in terms of future learning and cognitive development.<\/jats:p>","DOI":"10.3390\/children7090103","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T09:22:31Z","timestamp":1597828951000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evolving Cognitive Dysfunction in Children with Neurologically Stable Opsoclonus\u2013Myoclonus Syndrome"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-1803","authenticated-orcid":false,"given":"En Lin","family":"Goh","sequence":"first","affiliation":[{"name":"Oxford University Clinical Academic Graduate School, Medical Sciences Division, University of Oxford, Oxford OX3 9DU, UK"},{"name":"Department of Paediatrics, Children\u2019s Hospital Oxford, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Scarff","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuropsychology, Oxford Psychological Medicine Centre, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Satariano","sequence":"additional","affiliation":[{"name":"Children\u2019s Neuroscience Centre, Evelina London Children\u2019s Hospital, Guy\u2019s and St Thomas\u2019 NHS Trust, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lim","sequence":"additional","affiliation":[{"name":"Children\u2019s Neuroscience Centre, Evelina London Children\u2019s Hospital, Guy\u2019s and St Thomas\u2019 NHS Trust, London SE1 7EH, UK"},{"name":"Department of Women and Children\u2019s Health, Faculty of Life Sciences, King\u2019s College, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Children\u2019s Hospital Oxford, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpn.2009.03.002","article-title":"A prospective study of the presentation and management of dancing eye syndrome\/opsoclonus\u2013myoclonus syndrome in the United Kingdom","volume":"14","author":"Pang","year":"2010","journal-title":"Eur. 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