{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T22:09:26Z","timestamp":1777154966016,"version":"3.51.4"},"reference-count":111,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The ongoing worldwide pandemic of the novel human coronavirus SARS-CoV-2 and the ensuing disease, COVID-19, has presented enormous and unprecedented challenges for all medical specialists. However, to date, children, especially neonates, have been relatively spared from the devastating consequences of this infection. Neurologic involvement is being increasingly recognized among adults with COVID-19, who can develop sensory deficits in smell and taste, delirium, encephalopathy, headaches, strokes, and peripheral nervous system disorders. Among neonates and children, COVID-19-associated neurological manifestations have been relatively rare, yet reports involving neurologic dysfunction in this age range are increasing. As discussed in this review, pediatric neurologists and other pediatric specialists should be alert to potential neurological involvement by this virus, which might have neuroinvasive capability and carry long-term neuropsychiatric and medical consequences.<\/jats:p>","DOI":"10.3390\/children7090133","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T09:10:09Z","timestamp":1599729009000},"page":"133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["COVID-19: Neurological Considerations in Neonates and Children"],"prefix":"10.3390","volume":"7","author":[{"given":"Carl E.","family":"Stafstrom","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Departments of Neurology and Pediatrics, The Johns Hopkins University Hospital and School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren L.","family":"Jantzie","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurosurgery, and Neurology, The Johns Hopkins University Hospital and School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/acschemneuro.0c00122","article-title":"Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host\u2013Virus Interaction, and Proposed Neurotropic Mechanisms","volume":"11","author":"Baig","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbi.2020.03.031","article-title":"Nervous system involvement after infection with COVID-19 and other coronaviruses","volume":"87","author":"Wu","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_4","first-page":"awaa240","article-title":"The emerging spectrum of COVID-19 neurology: Clinical, radiological and laboratory findings","volume":"8","author":"Paterson","year":"2020","journal-title":"Brain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ana.25807","article-title":"COVID -19: A Global Threat to the Nervous System","volume":"88","author":"Koralnik","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fncel.2018.00386","article-title":"Neurologic Alterations Due to Respiratory Virus Infections","volume":"12","author":"Bohmwald","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105921","DOI":"10.1016\/j.clineuro.2020.105921","article-title":"Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review","volume":"194","author":"Montalvan","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Li, Z., Liu, T., Yang, N., Han, D., Mi, X., Li, Y., Liu, K., Vuylsteke, A., Xiang, H., and Guo, X. (2020). Neurological manifestations of patients with COVID-19: Potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain. Front. Med., 1\u20139.","DOI":"10.1007\/s11684-020-0786-5"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/138979","article-title":"Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections","volume":"2015","author":"Atluri","year":"2015","journal-title":"Neural Plast."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e20200702","DOI":"10.1542\/peds.2020-0702","article-title":"Epidemiology of COVID-19 among Children in China","volume":"145","author":"Dong","year":"2020","journal-title":"Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3906\/sag-2004-174","article-title":"Novel coronavirus disease (COVID-19) in children","volume":"50","author":"Tezer","year":"2020","journal-title":"Turk. J. Med Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/INF.0000000000002660","article-title":"Coronavirus Infections in Children Including COVID-19","volume":"39","author":"Zimmermann","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/apa.15271","article-title":"Why is COVID-19 so mild in children","volume":"109","author":"Brodin","year":"2020","journal-title":"Acta Paediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/cns.13372","article-title":"Neurological manifestations in COVID-19 caused by SARS-CoV-2","volume":"26","author":"Baig","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20143085","DOI":"10.1098\/rspb.2014.3085","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"Simon","year":"2015","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"110151","DOI":"10.1016\/j.mehy.2020.110151","article-title":"Why do children seem to be more protected against COVID-19? A hypothesis","volume":"143","author":"Sposato","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhu, L.Q., Lu, X., and Chen, L. (2020). Possible causes for decreased susceptibility of children to coronavirus. Pediatr. Res., 1\u20133.","DOI":"10.1038\/s41390-020-0892-8"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/INF.0000000000002700","article-title":"COVID-19 in Children, Pregnancy and Neonates","volume":"39","author":"Zimmermann","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: An observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","article-title":"Hyperinflammatory shock in children during COVID-19 pandemic","volume":"395","author":"Riphagen","year":"2020","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/INF.0000000000002815","article-title":"Intrauterine transmission of sars-cov-2 infection in a preterm infant","volume":"39","author":"Sisman","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E647","DOI":"10.1503\/cmaj.200821","article-title":"Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection","volume":"192","author":"Kirtsman","year":"2020","journal-title":"Can. Med. Assoc. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection","volume":"11","author":"Vivanti","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-020-03026-3","article-title":"Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: A report of 18 patients from Wuhan, China","volume":"20","author":"Zhang","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zeng, L., Xia, S., Yuan, W., Yan, K., Xiao, F., Shao, J., and Zhou, W. (2020). Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr.","DOI":"10.1001\/jamapediatrics.2020.0878"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11684-020-0772-y","article-title":"Clinical characteristics of 19 neonates born to mothers with COVID-19","volume":"14","author":"Liu","year":"2020","journal-title":"Front. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.5858\/arpa.2020-0901-SA","article-title":"An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes","volume":"144","author":"Schwartz","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/jmv.25740","article-title":"Coronavirus disease (COVID-19) and neonate: What neonatologist need to know","volume":"92","author":"Lu","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Salvatore, C.M., Han, J.-Y., Acker, K.P., Tiwari, P., Jin, J., Brandler, M., Cangemi, C., Gordon, L., Parow, A., and DiPace, J. (2020). Neonatal management and outcomes during the COVID-19 pandemic: An observation cohort study. Lancet Child Adolesc. Health, 2352.","DOI":"10.1016\/S2352-4642(20)30235-2"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/jama.2020.2131","article-title":"Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China","volume":"323","author":"Wei","year":"2020","journal-title":"JAMA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S2352-4642(20)30140-1","article-title":"COVID-19 in a 26-week preterm neonate","volume":"4","author":"Piersigilli","year":"2020","journal-title":"Lancet Child Adolesc. Heal."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Mehan, A., Venkatesh, A., and Girish, M. (2020). COVID-19 in pregnancy: Risk of adverse neonatal outcomes. J. Med. Virol.","DOI":"10.1002\/jmv.25959"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Abdoli, A., Falahi, S., Kenarkoohi, A., Shams, M., Mir, H., and Jahromi, M.A.M. (2020). The COVID-19 pandemic, psychological stress during pregnancy, and risk of neurodevelopmental disorders in offspring: A neglected consequence. J. Psychosom. Obstet. Gynecol., 1\u20132.","DOI":"10.1080\/0167482X.2020.1761321"},{"key":"ref_36","first-page":"hcaa226","article-title":"Psychosocial and coping responses towards 2019 coronavirus diseases (COVID-19): A cross-sectional study within the Chinese general population","volume":"17","author":"Li","year":"2020","journal-title":"QJM"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/aogs.13925","article-title":"Uptrend in distress and psychiatric symptomatology in pregnant women during the coronavirus disease 2019 pandemic","volume":"99","author":"Berthelot","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jpeds.2020.03.013","article-title":"Behavioral and Emotional Disorders in Children during the COVID-19 Epidemic","volume":"221","author":"Jiao","year":"2020","journal-title":"J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Lackey, K.A., Pace, R.M., Williams, J.E., Bode, L., Donovan, S.M., J\u00e4rvinen, K.M., Seppo, A.E., Raiten, D.J., Meehan, C.L., and McGuire, M.A. (2020). SARS-CoV-2 and human milk: What is the evidence. Matern. Child Nutr., e13032.","DOI":"10.1101\/2020.04.07.20056812"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41372-020-0665-6","article-title":"Perinatal aspects on the covid-19 pandemic: A practical resource for perinatal\u2013neonatal specialists","volume":"40","author":"Mimouni","year":"2020","journal-title":"J. Perinatol."},{"key":"ref_41","unstructured":"Puopolo, K.M., Hudak, M.L., Kimberlin, D.W., and Cummings, J. (2020). Initial Guidance: Management of Infants Born to Mothers with COVID-19, American Academy of Pediatrics Committee on Fetus and Newborn, Section on Neonatal Perinatal Medicine, and Commitee on Infectious Diseases."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ijgo.13146","article-title":"Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus ( COVID -19) infection","volume":"149","author":"Chen","year":"2020","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"116832","DOI":"10.1016\/j.jns.2020.116832","article-title":"Central nervous system manifestations of COVID-19: A systematic review","volume":"413","author":"Simani","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s12028-020-00978-4","article-title":"Neurological Implications of COVID-19 Infections","volume":"32","author":"Needham","year":"2020","journal-title":"Neurocrit. Care"},{"key":"ref_45","first-page":"24","article-title":"Novel Coronavirus Disease (COVID-19) and Central Nervous System Complications: What Neurologist Need to Know","volume":"29","author":"Paybast","year":"2020","journal-title":"Acta Neurol. Taiwan"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1056\/NEJMc2008597","article-title":"Neurologic features in severe SARS-CoV-2 infection","volume":"382","author":"Helms","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"59136","DOI":"10.7554\/eLife.59136","article-title":"Neuropathogenesis of SARS-CoV-2 infection","volume":"9","author":"Khan","year":"2020","journal-title":"Elife"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1056\/NEJMc2009787","article-title":"Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young","volume":"382","author":"Oxley","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/jnnp-2020-323586","article-title":"Characteristics of ischaemic stroke associated with COVID-19","volume":"91","author":"Beyrouti","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Christy, A. (2020). COVID-19: A Review for the Pediatric Neurologist. J. Child Neurol.","DOI":"10.1177\/0883073820939387"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ana.25783","article-title":"Steroid-Responsive Encephalitis in Coronavirus Disease 2019","volume":"88","author":"Pilotto","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1016\/S0140-6736(20)31282-4","article-title":"Early evidence of pronounced brain involvement in fatal COVID-19 outcomes","volume":"395","author":"Kaufmann","year":"2020","journal-title":"Lancet"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Solomon, I.H., Normandin, E., Bhattacharyya, S., Mukerji, S.S., Keller, K., Ali, A.S., Adams, G., Hornick, J.L., Padera, R.F., and Sabeti, P. (2020). Neuropathological Features of Covid-19. N. Engl. J. Med.","DOI":"10.1212\/WNL.96.15_supplement.4641"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1001\/jama.2020.8907","article-title":"Postmortem Examination of Patients With COVID-19","volume":"323","author":"Schaller","year":"2020","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e00782","DOI":"10.1016\/j.idcr.2020.e00782","article-title":"COVID-19 Presenting with Seizures","volume":"20","author":"Sohal","year":"2020","journal-title":"IDCases"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107122","DOI":"10.1016\/j.yebeh.2020.107122","article-title":"Epilepsy and COVID-19: Associations and important considerations","volume":"108","author":"Kuroda","year":"2020","journal-title":"Epilepsy Behav."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/epi4.12399","article-title":"EEG findings in acutely ill patients investigated for SARS-CoV-2\/COVID-19: A small case series preliminary report","volume":"5","author":"Galanopoulou","year":"2020","journal-title":"Epilepsia Open"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neucli.2020.06.001","article-title":"Electroencephalogram (EEG) in COVID-19: A systematic retrospective study","volume":"50","author":"Petrescu","year":"2020","journal-title":"Neurophysiol. Clin. Neurophysiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Poncet-Megemont, L., Paris, P., Tronchere, A., Salazard, J., Pereira, B., Dallel, R., Aumeran, C., Beytout, J., Jacomet, C., and Laurichesse, H. (2020). High Prevalence of Headaches During Covid-19 Infection: A Retrospective Cohort Study. Headache J. Head Face Pain.","DOI":"10.1111\/head.13923"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4193\/Rhin20.114","article-title":"Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome","volume":"58","author":"Gane","year":"2020","journal-title":"Rhinology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0194599820926464","article-title":"Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 with Public Health Significance","volume":"163","author":"Sedaghat","year":"2020","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuron.2020.06.032","article-title":"COVID-19 and the Chemical Senses: Supporting Players Take Center Stage","volume":"107","author":"Cooper","year":"2020","journal-title":"Neuron"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1097\/INF.0000000000002718","article-title":"Anosmia and Ageusia: Not an Uncommon Presentation of COVID-19 Infection in Children and Adolescents","volume":"39","author":"Mak","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e741","DOI":"10.1212\/NXI.0000000000000741","article-title":"Guillain-Barr\u00e9 syndrome related to COVID-19 infection","volume":"7","author":"Alberti","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1212\/NXI.0000000000000781","article-title":"Guillain-Barr\u00e9 syndrome: The first documented COVID-19\u2013triggered autoimmune neurologic disease","volume":"7","author":"Dalakas","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_66","first-page":"piaa086","article-title":"Guillain-Barr\u00e9 syndrome associated with severe accute respiratory syndrome coronoavirus 2 detection and coronavirus disease 2019 in a child","volume":"11","author":"Khalifa","year":"2020","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_67","first-page":"fmaa044","article-title":"Guillain-Barr\u00e9 syndrome associated with SARS-CoV-2 infection in a pediatric patient","volume":"12","author":"Frank","year":"2020","journal-title":"J. Trop. Pediatr."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Boziki, M.K., Mentis, A.-F.A., Shumilina, M., Makshakov, G., Evdoshenko, E., and Grigoriadis, N. (2020). COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination. Brain Sci., 10.","DOI":"10.3390\/brainsci10060345"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e761","DOI":"10.1212\/NXI.0000000000000761","article-title":"COVID-19 and MS disease-modifying therapies","volume":"7","author":"Berger","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_70","first-page":"1","article-title":"The Study Group of Neonatal Infectious Diseases of The Italian Society of Neonatology (SIN); Novel Coronavirus disease (COVID-19) in newborns and infants: What we know so far","volume":"46","author":"Piersigilli","year":"2020","journal-title":"Ital. J. Pediatr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0140-6736(20)30980-6","article-title":"Atypical presentation of COVID-19 in young infants","volume":"395","author":"Nathan","year":"2020","journal-title":"Lancet"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.anpede.2020.04.001","article-title":"COVID-19: Fever syndrome and neurological symptoms in a neonate","volume":"92","year":"2020","journal-title":"An. Pediatr (English Edition)"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lorenz, N., Treptow, A., Schmidt, S., Hofmann, R., Raumer-Engler, M., Heubner, G., and Gr\u00f6ber, K. (2020). Neonatal Early-Onset Infection With SARS-CoV-2 in a Newborn Presenting With Encephalitic Symptoms. Pediatr. Infect. Dis. J.","DOI":"10.1097\/INF.0000000000002735"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1212\/WNL.0000000000009653","article-title":"Neurologic manifestations in an infant with COVID-19","volume":"94","author":"Dugue","year":"2020","journal-title":"Neurology"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Bhatta, S., Sayed, A., Ranabhat, B., Bhatta, R.K., and Acharya, Y. (2020). New-Onset Seizure as the Only Presentation in a Child With COVID-19. Cureus.","DOI":"10.7759\/cureus.8820"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Nakra, N.A., Blumberg, D.A., Herrera-Guerra, A., and Lakshminrusimha, S. (2020). Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Children, 7.","DOI":"10.3390\/children7070069"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jpids\/piaa069","article-title":"Multisystem inflammatory syndrome in children during the COVID-19 pandemic: A case series","volume":"13","author":"Chiotos","year":"2020","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Whittaker, E., Bamford, A., Kenny, J., Kaforou, M., Jones, C.E., Shah, P., Ramnarayan, P., Fraisse, A., Miller, O., and Davies, P. (2020). Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA.","DOI":"10.1001\/jama.2020.10369"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"m2094","DOI":"10.1136\/bmj.m2094","article-title":"Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: Prospective observational study","volume":"369","author":"Toubiana","year":"2020","journal-title":"BMJ"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Feldstein, L.R., Rose, E.B., Horwitz, S.M., Collins, J.P., Newhams, M.M., Son, M.B.F., Newburger, J.W., Kleinman, L.C., Heidemann, S.M., and Martin, A.A. (2020). Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa2021680"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Abdel-Mannan, O., Eyre, M., L\u00f6bel, U., Bamford, A., Eltze, C., Hameed, B., Hemingway, C., and Hacohen, Y. (2020). Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children. JAMA Neurol.","DOI":"10.1001\/jamaneurol.2020.2687"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jon.12455","article-title":"Lesions in the Splenium of the Corpus Callosum on MRI in Children: A Review","volume":"27","author":"Kontzialis","year":"2017","journal-title":"J. Neuroimaging"},{"key":"ref_83","unstructured":"Abrams, J.Y., Godfred-Cato, S.E., Oster, M.E., Chow, E.J., Koumans, E.H., Bryant, B., Leung, J.W., and Belay, E.D. (2020). Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2: A Systematic Review. J. Pediatr., 22."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s10072-020-04469-4","article-title":"Potential neurological impact of coronaviruses: Implications for the novel SARS-CoV-2","volume":"41","author":"Iroegbu","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41577-020-0312-7","article-title":"COVID-19: Risk for cytokine targeting in chronic inflammatory diseases","volume":"20","author":"Schett","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cytogfr.2020.05.003","article-title":"The cytokine storm in COVID-19: An overview of the involvement of the chemokine\/chemokine-receptor system","volume":"53","author":"Coperchini","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology","volume":"39","author":"Channappanavar","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Kempuraj, D., Selvakumar, G.P., Ahmed, M.E., Raikwar, S.P., Thangavel, R., Khan, A., Zaheer, S.A., Iyer, S.S., Burton, C., and James, D. (2020). COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation. Neuroscience, 1\u201313.","DOI":"10.1177\/1073858420941476"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.molmed.2018.06.008","article-title":"The Impact of Systemic Inflammation on Neurodevelopment","volume":"24","author":"Jiang","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fped.2016.00128","article-title":"Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome","volume":"4","author":"Nye","year":"2016","journal-title":"Front. Pediatr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.120.15291","article-title":"ACE2, COVID-19, and ACE inhibitor and ARB use during the pandemic: The pediatric perspective","volume":"76","author":"South","year":"2020","journal-title":"Hypertension"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/cpmc.105","article-title":"Two detailed plaque assay protocols for the quantification of infectious SARS-CoV-2","volume":"57","author":"Mendoza","year":"2020","journal-title":"Curr. Protoc. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.virusres.2014.09.011","article-title":"Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis","volume":"194","author":"Desforges","year":"2014","journal-title":"Virus Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1128\/JVI.00737-08","article-title":"Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2","volume":"82","author":"Netland","year":"2008","journal-title":"J. Virol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Natoli, S., Oliveira, V., Calabresi, P., Maia, L.F., and Pisani, A. (2020). Does SARS-Cov-2 invade the brain? Translational lessons from animal models. Eur. J. Neurol.","DOI":"10.1111\/ene.14277"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/22221751.2020.1764871","article-title":"Animal models for emerging coronavirus: Progress and new insights","volume":"9","author":"Yuan","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sellner, J. (2020). Of mice and men: COVID-19 challenges translational neuroscience. Eur. J. Neurol.","DOI":"10.1111\/ene.14278"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Yazdanpanah, N., Saghazadeh, A., and Rezaei, N. (2020). Anosmia: A Missing Link in the Neuroimmunology of Coronavirus Disease 2019 (COVID-19). Rev. Neurosci., 1, Available online: 10:\/j\/revneuro.ahead-of-print\/revneuro-2020-0039\/revneuro-2020-0039.xml.","DOI":"10.1515\/revneuro-2020-0039"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Chen, M., Shen, W., Rowan, N.R., Kulaga, H., Hillel, A., Jr, M.R., and Lane, A.P. (2020). Elevated ACE2 expression in the olfactory neuroepithelium: Implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. Eur. Respir. J., 2001948.","DOI":"10.1101\/2020.05.08.084996"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2006.01.049","article-title":"Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB\/C mice","volume":"349","author":"Jacomy","year":"2006","journal-title":"Virology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"91.e1","DOI":"10.1016\/j.ajog.2020.04.039","article-title":"Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2","volume":"223","author":"Lamouroux","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2016.12.005","article-title":"Review: The blood-brain barrier; protecting the developing fetal brain","volume":"54","author":"Goasdoue","year":"2017","journal-title":"Placenta"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2020.04.080","article-title":"SARS-CoV2 entry and spread in the lymphatic drainage system of the brain","volume":"87","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tips.2020.05.005","article-title":"In Vitro and Animal Models for SARS-CoV-2 research","volume":"41","author":"Takayama","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/acschemneuro.0c00217","article-title":"Is the Collapse of the Respiratory Center in the Brain Responsible for Respiratory Breakdown in COVID-19 Patients","volume":"11","author":"Gandhi","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s41649-020-00118-2","article-title":"COVID-19 Super-spreaders: Definitional Quandaries and Implications","volume":"12","author":"Cave","year":"2020","journal-title":"Asian Bioeth. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1212\/WNL.0000000000009744","article-title":"Ethics, Law, and Humanities Committee, a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society; in collaboration with the Neurocritical Care Society Ethics Committee AAN position statement","volume":"95","author":"Rubin","year":"2020","journal-title":"Neurology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09297049.2020.1763938","article-title":"Neurotropic mechanisms in COVID-19 and their potential influence on neuropsychological outcomes in children","volume":"26","author":"Condie","year":"2020","journal-title":"Child Neuropsychol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/7\/9\/133\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:08:33Z","timestamp":1760177313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/7\/9\/133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":111,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["children7090133"],"URL":"https:\/\/doi.org\/10.3390\/children7090133","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]}}}