{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:27:51Z","timestamp":1767713271187,"version":"build-2065373602"},"reference-count":118,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Headaches are common complaints in children. The International Classification of Headache Disorders, 3rd edition (beta version), defines more than 280 types of headaches. Primary headaches refer to independent conditions that cause pain and include migraine, tension-type headaches (TTH), and trigeminal autonomic cephalalgias (TACs). Several agents are involved in the pathogenesis of headaches. The factors associated with predisposition to atherosclerosis seem to be particularly important from the clinical point of view. The influence of obesity on the incidence of headaches has been well established. Moreover, idiopathic headaches, especially migraine, are thought to be one of the first signs of disorders in lipid metabolism and atherosclerosis. The risk of migraine increases with increasing obesity in children. Another factor that seems to be involved in both obesity and headaches is the adiponectin level. Recent data also suggest new potential risk factors for atherosclerosis and platelet aggregation such as brain-derived neurotrophic factor (BDNF), sCD40L (soluble CD40 ligand), serpin E1\/PAI I (endothelial plasminogen activator inhibitor), and vascular endothelial growth factor (VEGF). However, their role is controversial because the results of clinical studies are often inconsistent. This review presents the current knowledge on the potential markers of atherosclerosis and platelet aggregation, which may be associated with primary headaches.<\/jats:p>","DOI":"10.3390\/children7100167","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T08:35:57Z","timestamp":1601886957000},"page":"167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Headache in Children: Selected Factors of Vascular Changes Involved in Underlying Processes of Idiopathic Headaches"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-504X","authenticated-orcid":false,"given":"Joanna","family":"Sordyl","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Pediatric Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Ma\u0142ecka-Tendera","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-8591","authenticated-orcid":false,"given":"Beata","family":"Sarecka-Hujar","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Kopyta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/archdischild-2016-311803","article-title":"Management of children and young people with headache","volume":"102","author":"Whitehouse","year":"2016","journal-title":"Arch. Dis. Child. Educ. Pr. Ed."},{"key":"ref_2","unstructured":"GBD 2016 Headache Collaborators (2018). Global, regional, and national burden of migraine and tension-type headache, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 17, 954\u2013976."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.amjmed.2017.09.005","article-title":"Headache","volume":"131","author":"Rizzoli","year":"2018","journal-title":"Am. J. Med."},{"key":"ref_4","first-page":"1","article-title":"Epidemiology of Migraine and Headache in Children and Adolescents","volume":"17","year":"2013","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1526-4610.2007.01052.x","article-title":"The child with headache in a pediatric emergency department","volume":"48","author":"Conicella","year":"2008","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1469-8749.2010.03793.x","article-title":"Prevalence of headache and migraine in children and adolescents: A systematic review of population-based studies","volume":"52","author":"Razak","year":"2010","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1212\/WNL.59.4.490","article-title":"Practice parameter: Evaluation of children and adolescents with recurrent headaches: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society","volume":"59","author":"Lewis","year":"2002","journal-title":"Neurology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/head.12150","article-title":"Sex Differences in the Prevalence, Symptoms, and Associated Features of Migraine, Probable Migraine and Other Severe Headache: Results of the American Migraine Prevalence and Prevention (AMPP) Study","volume":"53","author":"Buse","year":"2013","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1001\/archpedi.159.12.1157","article-title":"The Prognosis of Childhood Headache","volume":"159","author":"Brna","year":"2005","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_10","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) the International Classification of Headache Disorders. Cephalalgia, 38, 1\u2013211."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11916-018-0675-7","article-title":"Headache Diagnosis in Children and Adolescents","volume":"22","author":"Dao","year":"2018","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.3928\/19382359-20180129-02","article-title":"Management of Pediatric Migraine: Current Therapies","volume":"47","author":"Khrizman","year":"2018","journal-title":"Pediatr. Ann."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/14656566.2018.1552941","article-title":"Pharmacotherapy for acute migraines in children and adolescents","volume":"20","author":"Barbanti","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/papr.12229","article-title":"Correlation between Migraine Severity and Cholesterol Levels","volume":"15","author":"Tana","year":"2014","journal-title":"Pain Pr."},{"key":"ref_15","first-page":"188","article-title":"Dyslipidemia is Associated with Unfit and Overweight-Obese Children and Adolescents","volume":"106","author":"Reuter","year":"2016","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yang, S., Hwang, J.S., Park, H.K., Lee, H.S., Kim, H.S., Kim, E.Y., and Lim, J.S. (2012). Serum Lipid Concentrations, Prevalence of Dyslipidemia, and Percentage Eligible for Pharmacological Treatment of Korean Children and Adolescents; Data from the Korea National Health and Nutrition Examination Survey IV (2007\u20132009). PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049253"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/oby.2007.88","article-title":"Headaches in Overweight Children and Adolescents Referred to a Tertiary-care Center in Israel","volume":"16","author":"Frumin","year":"2008","journal-title":"Obesity"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1526-4610.2008.01232.x","article-title":"Obesity in the Pediatric Headache Population: A Multicenter Study","volume":"49","author":"Hershey","year":"2009","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/head.12088","article-title":"Obesity in Children With Headaches: Association With Headache Type, Frequency, and Disability","volume":"53","author":"Ravid","year":"2013","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1468-2982.2009.01907.x","article-title":"Obesity and pediatric migraine","volume":"30","author":"Kinik","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_21","first-page":"19","article-title":"Metabotrophic potential of neurotrophins:implication in obesity and related diseases?","volume":"9","author":"Chaldakov","year":"2003","journal-title":"Med. Sci. Monit."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1001\/archpediatrics.2010.17","article-title":"Headache and Biomarkers Predictive of Vascular Disease in a Representative Sample of US Children","volume":"164","author":"Nelson","year":"2010","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1468-2982.2005.01006.x","article-title":"Peripheral Levels of BDNF and NGF in Primary Headaches","volume":"26","author":"Blandini","year":"2006","journal-title":"Cephalalgia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10194-010-0233-0","article-title":"Increased serum levels of brain-derived neurotropic factor during migraine attacks: A pilot study","volume":"11","author":"Tanure","year":"2010","journal-title":"J. Headache Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10194-012-0454-5","article-title":"Brain-derived neurotrophic factor in primary headaches","volume":"13","author":"Fischer","year":"2012","journal-title":"J. Headache Pain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10194-011-0306-8","article-title":"Soluble CD40 ligand and prolactin levels in migraine patients during interictal period","volume":"12","author":"Guldiken","year":"2011","journal-title":"J. Headache Pain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4103\/aian.AIAN_371_18","article-title":"Association of Serum Levels of Calcitonin Gene-related Peptide and Cytokines during Migraine Attacks","volume":"22","author":"Han","year":"2019","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_28","first-page":"93","article-title":"Endothelial, haemostatic and haemorheological modifications in migraineurs","volume":"22","author":"Bianchi","year":"1996","journal-title":"Artery"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/brain\/awv359","article-title":"Migraine induced by hypoxia: An MRI spectroscopy and angiography study","volume":"139","author":"Arngrim","year":"2015","journal-title":"Brain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1212\/WNL.0b013e31826170ce","article-title":"Endothelial progenitor cells: A new key for endothelial dysfunction in migraine","volume":"79","author":"Sobrino","year":"2012","journal-title":"Neurology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1001\/jama.1989.03420150061038","article-title":"An epidemiologic study of headache among adolescents and young adults","volume":"261","author":"Linet","year":"1989","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/bmj.309.6957.765","article-title":"Prevalence of headache and migraine in schoolchildren","volume":"309","author":"Russell","year":"1994","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1469-8749.1992.tb11423.x","article-title":"Epidemiology of headache and childhood migraine in an urban general practice using Ad Hoc, Vahlquist and IHS criteria","volume":"34","author":"Mortimer","year":"1992","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000228238","article-title":"Migraine in Children","volume":"7","author":"Vahlquist","year":"1955","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1526-4610.1976.hed1504288.x","article-title":"Prevalence of migraine and other headache in finnish children starting school","volume":"15","year":"1976","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.112.1.e1","article-title":"Quality of life in childhood migraines: Clinical impact and comparison to other chronic illnesses","volume":"112","author":"Powers","year":"2003","journal-title":"Pediatrics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1526-4610.2007.00990.x","article-title":"Direct Cost Burden Among Insured US Employees With Migraine","volume":"48","author":"Hawkins","year":"2008","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1212\/WNL.0b013e3182a824f7","article-title":"Episodic migraine and obesity and the influence of age, race, and sex","volume":"81","author":"Peterlin","year":"2013","journal-title":"Neurology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1212\/WNL.0b013e3181eee244","article-title":"An unfavourable lifestyle and recurrent headaches among adolescents: The HUNT study","volume":"75","author":"Robberstad","year":"2010","journal-title":"Neurology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0883073811420869","article-title":"Chronic daily headache, medication overuse, and obesity in children andadolescents","volume":"27","author":"Pakalnis","year":"2012","journal-title":"J. Child Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1542\/peds.2012-1909","article-title":"Incidence and risk factors of chronic daily headache in young adolescents: A school cohort study","volume":"132","author":"Lu","year":"2013","journal-title":"Pediatrics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s13760-019-01134-2","article-title":"The role of obesity and vitamin D deficiency in primary headaches in childhood","volume":"120","author":"Hanci","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1468-1331.2012.03771.x","article-title":"Impact of a weight loss program on migraine in obese adolescents","volume":"20","author":"Verrotti","year":"2012","journal-title":"Eur. J. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/head.12296","article-title":"Obesity and Headache: Part I\u2014 a systematic review of the epidemiology of obesity and headache","volume":"54","author":"Chai","year":"2014","journal-title":"Headache"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/head.12297","article-title":"Obesity and headache: Part II--potential mechanism and treatment considerations","volume":"54","author":"Chai","year":"2014","journal-title":"Headache"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.clinthera.2008.06.005","article-title":"Weight change associated with the use of migraine-preventive medications","volume":"30","author":"Taylor","year":"2008","journal-title":"Clin. Ther."},{"key":"ref_47","first-page":"1014","article-title":"Use of the modified Atkins diet for adolescents with chronic daily headache","volume":"30","author":"Kossoff","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/cphy.c170046","article-title":"Adiponectin Regulation and Function","volume":"8","author":"Fang","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1212\/WNL.0000000000001443","article-title":"Ictal adipokines are associated with pain severity and treatment response in episodic migraine","volume":"84","author":"Chai","year":"2015","journal-title":"Neurology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/head.12788","article-title":"Adipokines and Migraine: A Systematic Review","volume":"56","author":"Peterlin","year":"2016","journal-title":"Headache: J. Head Face Pain"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/17477160801954538","article-title":"Adiponectin in childhood","volume":"3","author":"Jeffery","year":"2008","journal-title":"Pediatr. Obes."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/oby.2003.147","article-title":"Decrease in Serum Adiponectin Level Due to Obesity and Visceral Fat Accumulation in Children","volume":"11","author":"Asayama","year":"2003","journal-title":"Obes. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jns.2014.04.035","article-title":"Increased serum levels of adiponectin in migraine","volume":"342","author":"Duarte","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1590\/0004-282X20160096","article-title":"Serum levels of adiponectin, CCL3\/MIP-1\u03b1, and CCL5\/RANTES discriminate migraine from tension-type headache patients","volume":"74","author":"Domingues","year":"2016","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1212\/WNL.0000000000001067","article-title":"Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study","volume":"83","author":"Dearborn","year":"2014","journal-title":"Neurology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.atherosclerosis.2014.09.001","article-title":"Vascular oxidative stress, nitric oxide andatherosclerosis","volume":"237","author":"Li","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.arcmed.2016.11.009","article-title":"Hypercholesterolemia As a Risk Factor for Cardiovascular Disease: Current Controversial Therapeutic Management","volume":"47","author":"Saucedo","year":"2016","journal-title":"Arch. Med. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1542\/peds.77.3.316","article-title":"Migraine in children: Association with primary and familial dyslipoproteinaemias","volume":"3","author":"Glueck","year":"1986","journal-title":"Pediatrics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5114\/aoms.2018.73983","article-title":"Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches - a preliminary report","volume":"15","author":"Sordyl","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/0333102417699181","article-title":"The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)","volume":"38","author":"Goulart","year":"2017","journal-title":"Cephalalgia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1468-1331.2010.03199.x","article-title":"Headache, migraine and cardiovascular risk factors: The HUNT study","volume":"18","author":"Winsvold","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1001\/jama.2009.932","article-title":"Migraine Headache in Middle Age and Late-Life Brain Infarcts","volume":"301","author":"Scher","year":"2009","journal-title":"JAMA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s10194-016-0701-2","article-title":"The potential impact of primary headache disorders on stroke risk","volume":"17","author":"Tsai","year":"2016","journal-title":"J. Headache Pain"},{"key":"ref_64","first-page":"349","article-title":"Migraine as a vascular risk factor","volume":"55","author":"Larrosa","year":"2012","journal-title":"Rev. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000339676","article-title":"Stroke Mimics Treated with Thrombolysis: Further Evidence on Safety and Distinctive Clinical Features","volume":"34","author":"Caldentey","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.spen.2012.02.012","article-title":"Stroke and Cerebrovascular Complications in Childhood Cancer Survivors","volume":"19","author":"Partap","year":"2012","journal-title":"Semin. Pediatr. Neurol."},{"key":"ref_67","first-page":"41","article-title":"Lipid and coagulation profiles in children with arterial ischemic stroke depending on the presence of focal cerebral arteriopathy","volume":"1","author":"Kopyta","year":"2018","journal-title":"Eur. J. Med. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pediatrneurol.2017.09.019","article-title":"Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors","volume":"78","author":"Sultan","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijcard.2004.10.041","article-title":"Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes","volume":"102","author":"Manni","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/cns.12182","article-title":"Endothelial Nitric Oxide Synthase Protects Neurons against Ischemic Injury through Regulation of Brain-Derived Neurotrophic Factor Expression","volume":"20","author":"Li","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cca.2013.03.005","article-title":"Effects of weight loss on epicardial adipose tissue thickness and its relationship between serum soluble CD40 ligand levels in obese men","volume":"421","author":"Fu","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"ref_72","first-page":"151","article-title":"Soluble CD40 Ligand in Morbidly Obese Patients Effect of Body Mass Index on Recovery to Normal Levels After Gastric Bypass Surgery","volume":"2","author":"Pardina","year":"2013","journal-title":"JAMA Surg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3121\/cmr.2010.889","article-title":"The Levels of Soluble CD40 Ligand and C-Reactive Protein in Normal Weight, Overweight and Obese People","volume":"8","author":"Unek","year":"2010","journal-title":"Clin. Med. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1179\/1743132813Y.0000000190","article-title":"CD40 ligand as a potential biomarker for atherosclerotic instability","volume":"35","author":"Wang","year":"2013","journal-title":"Neurol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000350731","article-title":"Temporal Profile of Matrix Metalloproteinases and Their Inhibitors in a Human Endothelial Cell Culture Model of Cerebral Ischemia","volume":"35","author":"Reuter","year":"2013","journal-title":"Cerebrovasc. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11239-010-0474-4","article-title":"Prothrombotic markers in asymptomatic dyslipidemic subjects","volume":"31","author":"Karasek","year":"2010","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000087201","article-title":"Association of the Fibrinolytic System and Hemorheology with Symptoms in Patients with Carotid Occlusive Disease","volume":"20","author":"Soinne","year":"2005","journal-title":"Cerebrovasc. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1073\/pnas.96.14.7714","article-title":"Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord","volume":"96","author":"Thompson","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"9385","DOI":"10.1073\/pnas.96.16.9385","article-title":"Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity","volume":"96","author":"Mannion","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2174\/157015911798376208","article-title":"Role of Neurotrophins in Neuropathic Pain","volume":"9","author":"Siniscalco","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/j.1471-4159.2006.04161.x","article-title":"Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons","volume":"99","author":"Buldyrev","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s10194-017-0725-2","article-title":"The association between brain-derived neurotrophic factor gene polymorphism and migraine: A meta-analysis","volume":"18","author":"Cai","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fneur.2017.00159","article-title":"Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case\u2013Control Studies","volume":"8","author":"Terrazzino","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_84","first-page":"496","article-title":"rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model","volume":"4","author":"Zhang","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-015-0664-x","article-title":"Electroacupuncture analgesia is associated with increased serum brain-derived neurotrophic factor in chronic tension-type headache: A randomized, sham controlled, crossover trial","volume":"15","author":"Chassot","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pneurobio.2008.04.004","article-title":"BDNF as a pain modulator","volume":"85","author":"Merighi","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3109\/00207454.2013.840781","article-title":"Electroacupuncture enhances hippocampal NSCs proliferation in cerebral ischemia-reperfusion injured rats via activation of notch signaling pathway","volume":"124","author":"Tao","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/jnen\/61.2.142","article-title":"Effects of Brain-Derived Neurotrophic Factor (BDNF) on Compression-Induced Spinal Cord Injury: BDNF Attenuates Down-Regulation of Superoxide Dismutase Expression and Promotes Up-Regulation of Myelin Basic Protein Expression","volume":"61","author":"Ikeda","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1046\/j.1471-4159.1999.0720102.x","article-title":"Evidencethat brain-derived neurotrophic factor neuroprotection is linked to its abilityto reverse the NMDA-induced inactivation of protein kinase C in corticalneurons","volume":"72","author":"Tremblay","year":"1999","journal-title":"J. Neurochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jad.2014.11.044","article-title":"BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis","volume":"174","author":"Polyakova","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0306-4522(02)00963-6","article-title":"A calcium\/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic amp-responsive transcription factor in the rat hippocampus","volume":"118","author":"Blanquet","year":"2003","journal-title":"Neuroscience"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(01)06112-8","article-title":"Role of inflammatory biomarkers in prediction of coronary heart disease","volume":"358","author":"Ridker","year":"2001","journal-title":"Lancet"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1161\/hc4401.099447","article-title":"Soluble CD40L and Cardiovascular Risk in Women","volume":"104","author":"Varo","year":"2001","journal-title":"Circulation"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00062752-200309000-00006","article-title":"The platelet CD40L\/GP IIb-IIIa axis in atherothrombotic disease","volume":"10","author":"Prasad","year":"2003","journal-title":"Curr. Opin. Hematol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.CIR.0000028962.04520.01","article-title":"Platelet-Derived CD40L","volume":"106","author":"Prasad","year":"2002","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/01.CIR.96.2.396","article-title":"Activation of monocyte\/macrophage functions related to acute atheroma complication by ligation of CD40: Induction of collagenase, stromelysin, and tissue factor","volume":"96","author":"Mach","year":"1997","journal-title":"Circulation"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1161\/01.ATV.0000050143.22910.62","article-title":"Soluble CD40 Ligand Levels Indicate Lipid Accumulation in Carotid Atheroma","volume":"23","author":"Blake","year":"2003","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1073\/pnas.83.18.6776","article-title":"Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor","volume":"83","author":"Ny","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1042\/bj2390497","article-title":"Rapid inactivation of the plasminogen-activator inhibitor upon secretion from cultured human endothelial cells","volume":"239","author":"Kooistra","year":"1986","journal-title":"Biochem. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1016\/S0021-9258(20)64327-7","article-title":"Binding of plasminogen activator inhibitor type-1 to extracellular matrix of Hep G2 cells. Evidence that the binding protein is vitronectin","volume":"266","author":"Owensby","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/01.ATV.19.1.39","article-title":"On the Role of c-Jun in the Induction of PAI-1 Gene Expression by Phorbol Ester, Serum, and IL-1\u03b1 in HepG2 Cells","volume":"19","author":"Arts","year":"1999","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1291\/hypres.26.723","article-title":"Increased Expression of Plasminogen Activator Inhibitor-1 by Mediators of the Acute Phase Response: A Potential Progenitor of Vasculopathy in Hypertensives","volume":"26","author":"Dong","year":"2003","journal-title":"Hypertens. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1006\/jmcc.2002.2117","article-title":"Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators interleukin-1alpha, tumor necrosis factor-alpha, transforming growth factor-beta and oncostatin M in human cardiac myocytes","volume":"34","author":"Macfelda","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_104","first-page":"263","article-title":"Level of antithrombin III, protein C, protein S and other selected parameters of coagulation and fibrinolysis in the blood of the patients with recurrent deep venous thrombosis","volume":"8","author":"Swiatkiewicz","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/01.CIR.98.21.2241","article-title":"High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: Evidence for the fibrinolytic system as an independent primary risk factor","volume":"98","author":"Jansson","year":"1998","journal-title":"Circulation"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1161\/01.ATV.20.8.2019","article-title":"Plasma levels of tissue plasminogen activator\/plasminogen activator inhibitor-1 complex and von Willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study","volume":"20","author":"Wiman","year":"2000","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1053\/euhj.1997.0752","article-title":"Progression of coronary artery disease in young male post-infarction patients is linked to disturbances of carbohydrate and lipoprotein metabolism and to impaired fibrinolytic function","volume":"19","author":"Landou","year":"1998","journal-title":"Eur. Heart. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/01.hjr.0000116824.84388.a2","article-title":"Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction","volume":"11","author":"Jansson","year":"2004","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_109","first-page":"409","article-title":"Migraine, carotid stiffness and genetic polymorphism","volume":"54","author":"Kes","year":"2015","journal-title":"Acta Clin. Croat."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0333102416647037","article-title":"Hypoxic mechanisms in primary headaches","volume":"37","author":"Britze","year":"2016","journal-title":"Cephalalgia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/00207450903458647","article-title":"Migraine Associated with Patent Foramen Ovale May Be Caused by Reactivation of Cerebral Toxoplasmosis Triggered by Arterial Blood Oxygen Desaturation","volume":"120","author":"Prandota","year":"2010","journal-title":"Int. J. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4161\/adip.22880","article-title":"New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance","volume":"2","author":"Elias","year":"2013","journal-title":"Adipocyte"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrc905","article-title":"Clinical translation of angiogenesis inhibitors","volume":"2","author":"Kerbel","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.biocel.2007.04.010","article-title":"Vascular endothelial growthfactor: Biology and therapeutic applications","volume":"39","author":"Ho","year":"2007","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/dna.2010.1025","article-title":"Vascular Endothelial Growth Factor Genetic Polymorphisms and Haplotypes in Women with Migraine","volume":"29","author":"Speciali","year":"2010","journal-title":"DNA Cell Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s12017-017-8465-7","article-title":"The Levels of Circulating Proangiogenic Factors in Migraineurs","volume":"19","author":"Michalak","year":"2017","journal-title":"NeuroMolecular Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0002-9149(01)01486-2","article-title":"Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate","volume":"87","author":"Blann","year":"2001","journal-title":"Am. J. Cardiol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/7\/10\/167\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:16:29Z","timestamp":1760177789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/7\/10\/167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,4]]},"references-count":118,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["children7100167"],"URL":"https:\/\/doi.org\/10.3390\/children7100167","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2020,10,4]]}}}