{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:40:01Z","timestamp":1789756801457,"version":"4.0.1"},"reference-count":81,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Acute disseminated encephalomyelitis (ADEM) is an immune-mediated central nervous system (CNS) disorder, characterized by polyfocal symptoms, encephalopathy and typical magnetic resonance imaging (MRI) findings, that especially affects young children. Advances in understanding CNS neuroimmune disorders as well as the association of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) with both monophasic and recurrent forms of ADEM have led to new insights into its definition, management and outcome. In this review, we aim to provide an update based on current epidemiologic, clinical, radiological and immunopathological aspects and clinical outcome of ADEM.<\/jats:p>","DOI":"10.3390\/children7110210","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T09:09:32Z","timestamp":1604394572000},"page":"210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Acute Disseminated Encephalomyelitis: Current Perspectives"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3548-8467","authenticated-orcid":false,"given":"Renata Barbosa","family":"Paolilo","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo 05508-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaran","family":"Deiva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Assistance Publique-H\u00f4pitaux de Paris, University Hospitals Paris Saclay, Bic\u00eatre Hospital, 72, Rue G Leclerc, 94270 Le Kremlin Bic\u00eatre, France"},{"name":"National Reference Centre for Rare Inflammatory Brain and Spinal Diseases, 72, Rue G Leclerc, 94270 Le Kremlin Bic\u00eatre, France"},{"name":"Inserm UMR 1184, Immunology of Viral Infections and Autoimmune Diseases, 63, R G P\u00e9ri, 94270 Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinze","family":"Neuteboom","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-5321","authenticated-orcid":false,"given":"Kevin","family":"Rost\u00e1sy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Vestische Kinder und Jugendklinik, Witten\/Herdecke University, 45711 Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lim","sequence":"additional","affiliation":[{"name":"Children\u2019s Neurosciences, Evelina London Children\u2019s Hospital at Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London SE1 7EH, UK"},{"name":"King\u2019s Health Partners Academic Health Science Centre, London SE1 9RT, UK"},{"name":"Faculty of Life Sciences and Medicine, King\u2019s College Hospital, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1212\/WNL.0000000000002825","article-title":"Acute disseminated encephalomyelitis. 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