{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:08:28Z","timestamp":1777694908745,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The term children interstitial lung diseases (chILD) refers to a heterogeneous group of rare diseases that diffusely affect the lung. ChILD specific to children younger than 2 years of age include diffuse developmental disorders, growth abnormalities, specific conditions of undefined etiology (neuroendocrine cell hyperplasia of infancy and pulmonary interstitial glycogenosis) and surfactant protein disorders. Clinical manifestations are highly variable, ranging from the absence of relevant symptoms to a severe onset. Most commonly, chILD presents with nonspecific respiratory signs and symptoms, such as dyspnea, polypnea, dry cough, wheezing, recurrent respiratory infections and exercise intolerance. In the diagnostic approach to a child with suspected ILD, chest high resolution computed tomography and genetic tests play a central role. Then, if the diagnosis remains uncertain, laryngotracheal-bronchoscopy and lung biopsy are needed. Pharmacological treatment is mostly empiric and based on anti-inflammatory and immunomodulatory drugs including corticosteroids, hydroxychloroquine and azithromycin. Despite chILD overall rarity, pediatric pulmonologists must be familiar with these diseases in order to carry out a timely diagnosis and patient treatment.<\/jats:p>","DOI":"10.3390\/children7120280","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T09:17:58Z","timestamp":1607505478000},"page":"280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Children\u2019s Interstitial and Diffuse Lung Diseases (ChILD) in 2020"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-8519","authenticated-orcid":false,"given":"Valentina Agnese","family":"Ferraro","sequence":"first","affiliation":[{"name":"Pediatric Respiratory Medicine and Allergy Unit, Women\u2019s and Children\u2019s Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Zanconato","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Medicine and Allergy Unit, Women\u2019s and Children\u2019s Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Zamunaro","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Medicine and Allergy Unit, Women\u2019s and Children\u2019s Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-1225","authenticated-orcid":false,"given":"Silvia","family":"Carraro","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Medicine and Allergy Unit, Women\u2019s and Children\u2019s Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S2352-4642(19)30117-8","article-title":"Children\u2019s interstitial and diffuse lung disease","volume":"3","author":"Cunningham","year":"2019","journal-title":"Lancet Child Adolesc. 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