{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:43:49Z","timestamp":1789062229695,"version":"build-2803163510"},"reference-count":169,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Anorexia nervosa (AN) is a serious, multifactorial mental disorder affecting predominantly young females. This systematic review examines neuroimaging findings in adolescents and young adults up to 24 years old, in order to explore alterations associated with disease pathophysiology. Methods: Eligible studies on structural and functional brain neuroimaging were sought systematically in PubMed, CENTRAL and EMBASE databases up to 5 October 2020. Results: Thirty-three studies were included, investigating a total of 587 patients with a current diagnosis of AN and 663 healthy controls (HC). Global and regional grey matter (GM) volume reduction as well as white matter (WM) microstructure alterations were detected. The mainly affected regions were the prefrontal, parietal and temporal cortex, hippocampus, amygdala, insula, thalamus and cerebellum as well as various WM tracts such as corona radiata and superior longitudinal fasciculus (SLF). Regarding functional imaging, alterations were pointed out in large-scale brain networks, such as default mode network (DMN), executive control network (ECN) and salience network (SN). Most findings appear to reverse after weight restoration. Specific limitations of neuroimaging studies in still developing individuals are also discussed. Conclusions: Structural and functional alterations are present in the early course of the disease, most of them being partially or totally reversible. Nonetheless, neuroimaging findings have been open to many biological interpretations. Thus, more studies are needed to clarify their clinical significance.<\/jats:p>","DOI":"10.3390\/children8020137","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T18:45:00Z","timestamp":1613155500000},"page":"137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-3849","authenticated-orcid":false,"given":"Kalliopi","family":"Kappou","sequence":"first","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrto","family":"Ntougia","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Kourtesi","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Panagouli","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elpis","family":"Vlachopapadopoulou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Growth and Development, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Michalacos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Growth and Development, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-280X","authenticated-orcid":false,"given":"Fragiskos","family":"Gonidakis","sequence":"additional","affiliation":[{"name":"First Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, Eginition Hospital, 115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mastorakos","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Psaltopoulou","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"},{"name":"Department of Clinical Therapeutics, \u201cAlexandra\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsolia","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-0926","authenticated-orcid":false,"given":"Flora","family":"Bacopoulou","sequence":"additional","affiliation":[{"name":"Center for Adolescent Medicine and UNESCO Chair Adolescent Health Care, First Department of Pediatrics, \u201cAgia Sophia\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-5528","authenticated-orcid":false,"given":"Theodoros N.","family":"Sergentanis","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"},{"name":"Department of Clinical Therapeutics, \u201cAlexandra\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artemis","family":"Tsitsika","sequence":"additional","affiliation":[{"name":"MSc \u201cStrategies of Developmental and Adolescent Health\u201d, 2nd Department of Pediatrics, \u201cP. &amp; A. Kyriakou\u201d Children\u2019s Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"ref_1","first-page":"614","article-title":"Eating disorders in adolescents","volume":"36","author":"Gonzalez","year":"2007","journal-title":"Aust. Fam. 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