{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:16:37Z","timestamp":1784178997839,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Infants born through meconium-stained amniotic fluid (MSAF) are 100 times more likely than infants born through clear amniotic fluid to develop respiratory distress in the neonatal period. Meconium aspiration syndrome (MAS) is a common cause of respiratory distress in term and post-mature neonates. MAS is defined as respiratory distress accompanied by a supplemental oxygen requirement in an infant born with MSAF, in the absence of any other identified etiology to explain the symptoms. Therapy for MAS is supportive, and should be tailored to each infant\u2019s specific pathophysiology. In cases of MAS with severe persistent pulmonary hypertension of the newborn (PPHN), patients may remain hypoxic despite aggressive ventilation, and in these cases surfactant, inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO) can be life-saving. Long-term prognosis for MAS is more related to severity of initial hypoxemia and possible neurological insult than to the pulmonary pathology.<\/jats:p>","DOI":"10.3390\/children8030246","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T14:08:16Z","timestamp":1616508496000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome"],"prefix":"10.3390","volume":"8","author":[{"given":"Arielle L.","family":"Olicker","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University, UH Rainbow Babies &amp; Children\u2019s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-8719","authenticated-orcid":false,"given":"Thomas M.","family":"Raffay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University, UH Rainbow Babies &amp; Children\u2019s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4588-3412","authenticated-orcid":false,"given":"Rita M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University, UH Rainbow Babies &amp; Children\u2019s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref_1","unstructured":"Martin, R.J., Fanaroff, A.A., and Walsh, M.C. (2020). Fanaroff and Martin\u2019s Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant, Elsevier. [11th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000369373","article-title":"Meconium aspiration syndrome: Possible pathophysiological mechanisms and future potential therapies","volume":"107","author":"Lindenskov","year":"2015","journal-title":"Neonatology"},{"key":"ref_3","unstructured":"Fanaroff, A.A., Fanaroff, J.M., and Klaus, M.H. (2013). Klaus & Fanaroff\u2019s Care of the High-Risk Neonate, Elsevier\/Saunders. [6th ed.]."},{"key":"ref_4","first-page":"731","article-title":"Changing obstetric practices associated with decreasing incidence of meconium aspiration syndrome","volume":"99","author":"Yoder","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jpeds.2008.09.013","article-title":"Variations in mortality and morbidity by gestational age among infants born at term","volume":"154","author":"Zhang","year":"2009","journal-title":"J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1542\/peds.2005-2215","article-title":"The epidemiology of meconium aspiration syndrome: Incidence, risk factors, therapies, and outcome","volume":"117","author":"Dargaville","year":"2006","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1203\/pdr.0b013e31802d8a81","article-title":"Elevated plasma corticotrophin release factor levels and in utero meconium passage","volume":"61","author":"Lakshmanan","year":"2007","journal-title":"Pediatr. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1067\/mob.2003.107","article-title":"Defecation in utero: A physiologic fetal function","volume":"188","author":"Martinez","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/01443610701469636","article-title":"Risk factors for meconium aspiration in meconium stained amniotic fluid","volume":"27","author":"Khazardoost","year":"2007","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s12098-016-2128-9","article-title":"Current Concepts in the Management of Meconium Aspiration Syndrome","volume":"83","author":"Chettri","year":"2016","journal-title":"Indian J. Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1055\/s-0037-1620269","article-title":"Approach to Infants Born Through Meconium Stained Amniotic Fluid: Evolution Based on Evidence?","volume":"35","author":"Rawat","year":"2018","journal-title":"Am. J. Perinatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1542\/peds.109.6.1081","article-title":"A multicenter, randomized, controlled trial comparing Surfaxin (Lucinactant) lavage with standard care for treatment of meconium aspiration syndrome","volume":"109","author":"Wiswell","year":"2002","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sj.jp.7200139","article-title":"Resuscitation of the meconium-stained infant and prevention of meconium aspiration syndrome","volume":"19","author":"Fuloria","year":"1999","journal-title":"J. Perinatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.molimm.2008.09.001","article-title":"Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood","volume":"46","author":"Salvesen","year":"2009","journal-title":"Mol. Immunol."},{"key":"ref_15","unstructured":"Goldsmith, J.P., and Karotkin, E.H. (2011). Assisted Ventilation of the Neonate, Elsevier\/Saunders. [5th ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/jp.2016.32","article-title":"Surfactant therapy and antibiotics in neonates with meconium aspiration syndrome: A systematic review and meta-analysis","volume":"36","author":"Natarajan","year":"2016","journal-title":"J. Perinatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jpeds.2006.07.027","article-title":"Surfactant phosphatidylcholine metabolism in neonates with meconium aspiration syndrome","volume":"149","author":"Janssen","year":"2006","journal-title":"J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.105.1.1","article-title":"Delivery room management of the apparently vigorous meconium-stained neonate: Results of the multicenter, international collaborative trial","volume":"105","author":"Wiswell","year":"2000","journal-title":"Pediatrics"},{"key":"ref_19","first-page":"1051","article-title":"Intrapartum amnioinfusion for meconium-stained fluid: Meta-analysis of prospective clinical trials","volume":"95","author":"Pierce","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJMoa050223","article-title":"Amnioinfusion for the prevention of the meconium aspiration syndrome","volume":"353","author":"Fraser","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/00006250-200610000-00048","article-title":"ACOG Committee Opinion Number 346, October 2006: Amnioninfusion does not prevent meconium aspiration syndrome","volume":"108","author":"Practice","year":"2006","journal-title":"Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0140-6736(04)16852-9","article-title":"Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: Multicentre, randomised controlled trial","volume":"364","author":"Vain","year":"2004","journal-title":"Lancet"},{"key":"ref_23","unstructured":"American Heart Association (2016). Textbook of Neonatal Resuscitation, American Acadamy of Pediatrics and the American Heart Association. [7th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S516","DOI":"10.1161\/CIRCULATIONAHA.110.971127","article-title":"Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations","volume":"122","author":"Perlman","year":"2010","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.1161\/CIR.0000000000000276","article-title":"Part 7: Neonatal Resuscitation: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations","volume":"132","author":"Perlman","year":"2015","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1203\/PDR.0b013e3181bab0c7","article-title":"Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension","volume":"66","author":"Lakshminrusimha","year":"2009","journal-title":"Pediatr. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"El Shahed, A.I., Dargaville, P., Ohlsson, A., and Soll, R.F. (2007). Surfactant for meconium aspiration syndrome in full term\/near term infants. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD002054.pub2"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"El Shahed, A.I., Dargaville, P.A., Ohlsson, A., and Soll, R. (2014). Surfactant for meconium aspiration syndrome in term and late preterm infants. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD002054.pub3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1440-1754.2007.01130.x","article-title":"Therapeutic lung lavage in meconium aspiration syndrome: A preliminary report","volume":"43","author":"Dargaville","year":"2007","journal-title":"J. Paediatr. Child Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpeds.2010.08.044","article-title":"Randomized controlled trial of lung lavage with dilute surfactant for meconium aspiration syndrome","volume":"158","author":"Dargaville","year":"2011","journal-title":"J. Pediatr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0022-3476(98)70482-2","article-title":"Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group","volume":"132","author":"Lotze","year":"1998","journal-title":"J. Pediatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1136\/fn.84.1.F1","article-title":"Meconium aspiration syndrome and extracorporeal membrane oxygenation","volume":"84","author":"Davis","year":"2001","journal-title":"Arch. Dis. Child. 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