{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:14:03Z","timestamp":1761808443866,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["RO3HD096510, RO1HD072929"],"award-info":[{"award-number":["RO3HD096510, RO1HD072929"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K12 HL138052"],"award-info":[{"award-number":["K12 HL138052"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>(1) Background: Optimal initial oxygen (O2) concentration in preterm neonates is controversial. Our objectives were to compare the effect of delayed cord clamping with ventilation (DCCV) to early cord clamping followed by ventilation (ECCV) on O2 exposure, gas exchange, and hemodynamics in an asphyxiated preterm ovine model. (2) Methods: Asphyxiated preterm lambs (127\u2013128 d) with heart rate &lt;90 bpm were randomly assigned to DCCV or ECCV. In DCCV, positive pressure ventilation (PPV) was initiated with 30\u201360% O2 and titrated based on preductal saturations (SpO2) with an intact cord for 5 min, followed by clamping. In ECCV, the cord was clamped, and PPV was initiated. (3) Results: Fifteen asphyxiated preterm lambs were randomized to DCCV (N = 7) or ECCV (N = 8). The inspired O2 (40 \u00b1 20% vs. 60 \u00b1 20%, p &lt; 0.05) and oxygen load (520 (IQR 414\u2013530) vs. 775 (IQR 623\u2013868), p-0.03) in the DCCV group were significantly lower than ECCV. Arterial oxygenation and carbon dioxide (PaCO2) levels were significantly lower and peak pulmonary blood flow was higher with DCCV. (4) Conclusion: In asphyxiated preterm lambs, resuscitation with an intact cord decreased O2 exposure load improved ventilation with an increase in peak pulmonary blood flow in the first 5 min.<\/jats:p>","DOI":"10.3390\/children8040307","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T22:15:13Z","timestamp":1618784113000},"page":"307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-3017","authenticated-orcid":false,"given":"Praveen","family":"Chandrasekharan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Gugino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Helman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmon","family":"Koenigsknecht","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3846-2027","authenticated-orcid":false,"given":"Jayasree","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-7197","authenticated-orcid":false,"given":"Vikash","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Loma Linda University, Loma Linda, CA 92350, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mausma","family":"Bawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-0345","authenticated-orcid":false,"given":"Andreina","family":"Mari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munmun","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine &amp; Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2155","authenticated-orcid":false,"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,17]]},"reference":[{"unstructured":"American Academy of Pediatrics (2016). 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