{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:02:58Z","timestamp":1760234578074,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Studies report the link between exposure to major neonatal surgery and the risk of later neurodevelopmental disorders. The aim of this study was to find out the behavioral problem scores of 2.5\u20135 years old children who had undergone median\/major non-cardiac surgery before the age of 90 days, and to relate these to intraoperative cerebral tissue oxygenation values (rSO2), perioperative duration of mechanical ventilation (DMV) and doses of sedative\/analgesic agents. Internalizing (IP) and externalizing problems (EP) of 34 children were assessed using the CBCL for ages 1\u00bd\u20135. Median (range) IP and EP scores were 8.5 (2\u201342) and 15.5 (5\u201333), respectively and did not correlate with intraoperative rSO2. DMV correlated and was predictive for EP (\u03b2 (95% CI) 0.095 (0.043; 0.148)). An aggregate variable \u201copioid dose per days of ventilation\u201d was predictive for EP after adjusting for patients\u2019 gestational age and age at the day of psychological assessment, after further adjustment for age at the day of surgery and for cumulative dose of benzodiazepines (\u03b2 (95% CI 0.009 (0.003; 0.014) and 0.008 (0.002; 0.014), respectively). Neonatal\/infantile intraoperative cerebral oxygenation was not associated with later behavioral problems. The risk factors for externalizing problems appeared to be similar to the risk factors in preterm infant population.<\/jats:p>","DOI":"10.3390\/children8050423","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T06:13:45Z","timestamp":1621491225000},"page":"423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Behavioral Problems in 2.5\u20135 Years Old Children Linked with Former Neonatal\/Infantile Surgical Parameters"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-2217","authenticated-orcid":false,"given":"Danguol\u0117","family":"Rugyt\u0117","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giedr\u0117","family":"\u0160irvinskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Health Psychology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Health Research Institute, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-7063","authenticated-orcid":false,"given":"Rima","family":"Kreg\u017edyt\u0117","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Neuroscience Institute, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F227","DOI":"10.1136\/archdischild-2017-313161","article-title":"Victorian Infant Collaborative Study Group. 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