{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:48:19Z","timestamp":1771534099533,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The hip joint involvement in multiple hereditary exostoses (MHE) occurs in 30\u201390%, causing pain and limitation of motion by femoroacetabular impingement, coxa valga, acetabular dysplasia, hip joint subluxation, and osteoarthritis. The purpose of this study was to investigate the clinical and radiographic outcomes of ten hips in seven patients treated by surgical dislocation and corrective osteotomies between 2004 and 2009. Surgical dislocation and excision of the osteochondromas and varus intertrochanteric osteotomies were performed in all cases when the neck\u2013shaft angle was &gt; 150\u00b0. Common sites of osteochondromas were medial, posterior, and anterior neck of the femur. Neck\u2013shaft angle of the femur was improved from a mean of 157\u00b0 to 139\u00b0, postoperatively. On an average, the center-edge angle improved from 20\u00b0 to 30\u00b0 postoperatively. We believe that Ganz\u2019s safe surgical dislocation technique is the preferred treatment of MHE. This safeguards the circulation of the femoral head and the osteochondromas can be resected under direct vision. It can be combined with additional corrective osteotomies because the hip affected by MHE is frequently associated with dysplastic changes which can result in premature osteoarthritis.<\/jats:p>","DOI":"10.3390\/children8060490","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:08:55Z","timestamp":1623154135000},"page":"490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reconstruction of the Hip in Multiple Hereditary Exostoses"],"prefix":"10.3390","volume":"8","author":[{"given":"Dong Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Donghoon Advanced Lengthening Reconstruction Institute, Superstar tower 3-5F 10, Wiryeseoil-ro, Sujeong-gu, Seongnam-si 11962, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-3459","authenticated-orcid":false,"given":"Dror","family":"Paley","sequence":"additional","affiliation":[{"name":"Paley Orthopedic and Spine Institute, Kimmel, 901 45th St, West Palm Beach, FL 33407, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.2106\/00004623-199407000-00005","article-title":"The natural history of hereditary multiple exostoses","volume":"76","author":"Schmale","year":"1994","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ng1095-137","article-title":"Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)","volume":"11","author":"Ahn","year":"1995","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0996-25","article-title":"The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes","volume":"14","author":"Stickens","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5435\/00124635-200503000-00004","article-title":"Manifestations of hereditary multiple exostoses","volume":"13","author":"Stieber","year":"2005","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1302\/0301-620X.83B7.0830988","article-title":"The hip in hereditary multiple exostoses","volume":"83","author":"Porter","year":"2001","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_6","first-page":"351","article-title":"Hereditary multiple exostosis","volume":"16","author":"Solomon","year":"1964","journal-title":"Am. J. Hum. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2106\/00004623-197961060-00003","article-title":"Hereditary multiple exostoses. Anthropometric, roentgenographic, and clinical aspects","volume":"61","author":"Shapiro","year":"1979","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_8","first-page":"187","article-title":"The development of the upper end of the femur in multiple hereditary exostosis","volume":"137","author":"Weiner","year":"1978","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1302\/0301-620X.82B4.0820555","article-title":"Acetabular dysplasia associated with hereditary multiple exostoses. A case report","volume":"82","author":"Felix","year":"2000","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/01202412-200411000-00004","article-title":"Progressive subluxation of the hip joint in a child with hereditary multiple exostosis","volume":"13","author":"Ofiram","year":"2004","journal-title":"J. Pediatr. Orthop. B"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/BPO.0b013e3181a56b4f","article-title":"Surgical hip dislocation for removal of intraarticular exostoses: Report of two cases","volume":"29","author":"Jellicoe","year":"2009","journal-title":"J. Pediatr. Orthop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01241398-199901000-00025","article-title":"Subluxation of the hip joint in multiple hereditary osteochondromatosis: Report of two cases","volume":"19","author":"Woodward","year":"1999","journal-title":"J. Pediatr. Orthop."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0030-5898(20)32103-9","article-title":"Benign cartilage tumors","volume":"27","author":"Scarborough","year":"1996","journal-title":"Orthop. Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/112070000901900316","article-title":"Bilateral total hip arthroplasty in Severe Hereditary Multiple Exostosis: A report of two cases","volume":"19","author":"Moran","year":"2009","journal-title":"Hip Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00003086-198510000-00023","article-title":"Intra-articular osteochondromas of the hip joint in a child with multiple osteochondromas. Case report","volume":"199","author":"Gore","year":"1985","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1053\/jars.2001.22410","article-title":"Hip arthroscopy in hereditary multiple exostoses: A new perspective of treatment","volume":"17","author":"Bonnomet","year":"2001","journal-title":"Arthroscopy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4055\/cios.2009.1.3.132","article-title":"Application of Ganz surgical hip dislocation approach in pediatric hip diseases","volume":"1","author":"Shin","year":"2009","journal-title":"Clin. Orthop. Surg."},{"key":"ref_18","first-page":"31","article-title":"The orthopaedic manifestations of the Langer-Giedion syndrome","volume":"21","author":"Bauermeister","year":"1992","journal-title":"Orthop. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/17453677608988709","article-title":"The CE angle of normal hips","volume":"47","author":"Fredensborg","year":"1976","journal-title":"Acta Orthop. Scand."},{"key":"ref_20","first-page":"79","article-title":"Acetabular dysplasia in the adult. Clin. Orthop","volume":"175","author":"Cooperman","year":"1983","journal-title":"Relat. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1302\/0301-620X.83B8.0831119","article-title":"Surgical dislocation of the adult hip a technique with full access to the femoral head and acetabulum without the risk of avascular necrosis","volume":"83","author":"Ganz","year":"2001","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.2106\/00004623-200608000-00007","article-title":"Treatment of femoro-acetabular impingement with surgical dislocation and debridement in young adults","volume":"88","author":"Peters","year":"2006","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2106\/00004623-200704000-00011","article-title":"Quality of life following femoral head-neck osteochondroplasty for femoroacetabular impingement","volume":"89","author":"Zaragoza","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_24","first-page":"747","article-title":"Femoroacetabular impingement treatment using arthroscopy and anterior approach. Clin. Orthop","volume":"467","author":"Laude","year":"2009","journal-title":"Relat. Res."},{"key":"ref_25","first-page":"112","article-title":"Femoroacetabular impingement: A cause for osteoarthritis of the hip. Clin. Orthop","volume":"417","author":"Ganz","year":"2003","journal-title":"Relat. Res."},{"key":"ref_26","first-page":"182","article-title":"Arthroscopic treatment of femoroacetabular impingement of the hip: A new technique to access the joint. Clin. Orthop","volume":"468","author":"Horisberger","year":"2010","journal-title":"Relat. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s11999-009-1138-6","article-title":"Surgical treatment of femoroacetabular impingement: A systematic review of the literature","volume":"468","author":"Clohisy","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"43S","DOI":"10.1177\/0363546511414635","article-title":"Surgical treatment of femoroacetabular impingement improves hip kinematics: A computer-assisted model","volume":"39","author":"Bedi","year":"2011","journal-title":"Am. J. Spots Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0363546509346393","article-title":"Arthroscopic labral repair and treatment of femoroacetabular impingement in professional hockey players","volume":"38","author":"Philippon","year":"2010","journal-title":"Am. J. Sports Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1302\/0301-620X.89B8.19152","article-title":"Arthroscopic treatment of femoroacetabular impingement secondary to paediatric hip disorders","volume":"89","author":"Ilizaliturri","year":"2007","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.arthro.2013.06.010","article-title":"Surgical dislocation of the hip Versus arthroscopic treatment of femoroacetabular impingement: A prospective matched-pair study With average 2-year follow-up","volume":"29","author":"Domb","year":"2013","journal-title":"Arthroscopy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1177\/0363546515624682","article-title":"Outcomes After arthroscopic treatment of femoroacetabular impingement for patients With borderline hip dysplasia","volume":"44","author":"Nawabi","year":"2016","journal-title":"Am. J. Spots Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.arthro.2017.04.008","article-title":"ASArthroscopic treatment of femoroacetabular impingement in adolescents provides clinically significant outcome improvement","volume":"33","author":"Nwachukwu","year":"2017","journal-title":"Arthroscopy"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ahn, Y.S., Kim, S., Kim, W.J., Lim, J.H., and Jung, S.T. (2021). Characteristics of hip impingement syndrome in patients with multiple hereditary exostoses. BMC. Musculoskelet. Disord., 22.","DOI":"10.1186\/s12891-021-04021-1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11914-017-0355-2","article-title":"Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments","volume":"15","author":"Pacifici","year":"2017","journal-title":"Curr. Osteoporos Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01241398-200103000-00014","article-title":"Development of hip dysplasia in hereditary multiple exostosis","volume":"21","year":"2001","journal-title":"J. Pediatr. Orthop."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1302\/0301-620X.98B2.36521","article-title":"Surgical hip dislocation according to Ganz for excision of osteochondromas in patients with multiple hereditary exostoses","volume":"98\u2013B","author":"Sorel","year":"2016","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00402-017-2644-8","article-title":"Surgical dislocation for pediatric and adolescent hip deformity: Clinical and radiographical results at 3 years follow-up","volume":"137","author":"Guindani","year":"2017","journal-title":"Arch. Orthop. Trauma. Surg."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/6\/490\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:12:15Z","timestamp":1760163135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/6\/490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["children8060490"],"URL":"https:\/\/doi.org\/10.3390\/children8060490","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]}}}