{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:59:30Z","timestamp":1771369170530,"version":"3.50.1"},"reference-count":6,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Severe desaturation or bradycardia often occur during neonatal endotracheal intubation. Using continuous gas flow through the endotracheal tube might reduce the incidence of these events. We hypothesized that continuous gas flow through the endotracheal tube during nasotracheal intubation compared to standard nasotracheal intubation will reduce the number of intubation attempts in newborn infants. In a randomized controlled pilot study, neonates were either intubated with continuous gas flow through the endotracheal tube during intubation (intervention group) or no gas flow during intubation (control group). Recruitment was stopped early due to financial and organizational issues. A total of 16 infants and 39 intubation attempts were analyzed. The median (interquartile range) number of intubation attempts and number of abandoned intubations due to desaturation and\/or bradycardia were 1 (1\u20132) and 4 (2\u20135), (p = 0.056) and n = 3 versus n = 20, (p = 0.060) in the intervention group and control group, respectively. Continuous gas flow through the endotracheal tube during intubation seems to be favorable and there are no major unexpected adverse consequences of attempting this methodology.<\/jats:p>","DOI":"10.3390\/children8070553","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T22:24:57Z","timestamp":1624832697000},"page":"553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In Newborn Infants a New Intubation Method May Reduce the Number of Intubation Attempts: A Randomized Pilot Study"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-7597","authenticated-orcid":false,"given":"Marlies","family":"Bruckner","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-7143","authenticated-orcid":false,"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"},{"name":"Research Unit for Neonatal Macro- and Microcirculation, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-3487","authenticated-orcid":false,"given":"Christina H.","family":"Wolfsberger","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Heschl","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Pediatric Anesthesia, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-665X","authenticated-orcid":false,"given":"Lukas P.","family":"Mileder","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-3712","authenticated-orcid":false,"given":"Bernhard","family":"Schwaberger","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-2415","authenticated-orcid":false,"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[{"name":"Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, 10240 Kingsway Avenue NW, Edmonton, AB T5H 3V9, Canada"},{"name":"Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 11405-87 Avenue, Edmonton, AB T6G 1C9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berndt","family":"Urlesberger","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"},{"name":"Research Unit for Cerebral Development and Oximetry Research, Medical University of Graz, Auenbruggerplatz 34\/2, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e20180902","DOI":"10.1542\/peds.2018-0902","article-title":"Neonatal Intubation Practice and Outcomes: An International Registry Study","volume":"143","author":"Foglia","year":"2019","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpeds.2015.09.077","article-title":"Endotracheal Intubation in Neonates: A Prospective Study of Adverse Safety Events in 162 Infants","volume":"168","author":"Hatch","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S2213-2600(15)00508-1","article-title":"Airway management complications in children with difficult tracheal intubation from the Pediatric Difficult Intubation (PeDI) registry: A prospective cohort analysis","volume":"4","author":"Fiadjoe","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/pan.13645","article-title":"Apneic nasal oxygenation prolongs safe apnea time during pediatric intubations by learners","volume":"29","author":"Soneru","year":"2019","journal-title":"Pediatr. Anesth."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1542\/peds.2007-2352","article-title":"Propofol Compared with the Morphine, Atropine, and Suxamethonium Regimen as Induction Agents for Neonatal Endotracheal Intubation: A Randomized, Controlled Trial: In Reply","volume":"120","author":"Oei","year":"2007","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmjopen-2020-039230","article-title":"A multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation (the SHINE trial): A study protocol","volume":"10","author":"Hodgson","year":"2020","journal-title":"BMJ Open"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/7\/553\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:36Z","timestamp":1760163876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/7\/553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":6,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["children8070553"],"URL":"https:\/\/doi.org\/10.3390\/children8070553","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]}}}