{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:11:33Z","timestamp":1760235093774,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objectives: T-cell mediated rejection (TCMR) can compromise long-term liver allograft survival. The immunomodulatory properties of vitamin D are increasingly recognized. We investigated whether perturbations in vitamin D metabolism prior to LT may predispose to TCMR in a representative cohort of paediatric LT recipients. Methods: In this retrospective single-center study of children who underwent liver transplantation between 2005 and 2017, we collected serum 25(OH) vitamin D levels and other parameters related to vitamin D metabolism. Post-transplant variables were collected from medical records during the first year following LT. Results: Eighty-two patients were included. Twenty-six (32%) developed TCMR, 52 (65%) presented at least one event of 25(OH) D insufficiency during the year before the transplant, while 23 (32%) had at least one documented elevated plasma parathyroid hormone level. Forty-six patients benefited from nutritional support (56%). The development of TCMR was associated with vitamin D insufficiency pre-LT (p = 0.01). No significant correlations were identified between PTH levels and incidence of TCMR. The association was stronger in patients transplanted for cholestatic diseases (p = 0.004). Conclusions: Vitamin D insufficiency before a liver transplant may be associated with TCMR during the first year post-LT. These findings warrant further investigation.<\/jats:p>","DOI":"10.3390\/children8070612","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T05:10:59Z","timestamp":1626757859000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D Insufficiency Prior to Paediatric Liver Transplantation Is Associated with Early T-Cell Mediated Rejection"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-9267","authenticated-orcid":false,"given":"Nathalie M.","family":"Rock","sequence":"first","affiliation":[{"name":"Swiss Paediatric Liver Center, Paediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Paediatric Specialties, Department of Paediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, 6, Rue Willy-Donz\u00e9, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Anghileri","sequence":"additional","affiliation":[{"name":"Swiss Paediatric Liver Center, Paediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Paediatric Specialties, Department of Paediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, 6, Rue Willy-Donz\u00e9, 1211 Geneva, Switzerland"},{"name":"School for General Medicine, Polis Lombardia, via Taramelli 12, 20124 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir L.","family":"Cousin","sequence":"additional","affiliation":[{"name":"Swiss Paediatric Liver Center, Paediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Paediatric Specialties, Department of Paediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, 6, Rue Willy-Donz\u00e9, 1211 Geneva, Switzerland"},{"name":"Division of Intensive Care, Department of Acute Medicine, Geneva University Hospitals, University of Geneva, Rue Gabriel-Perret Gentil 4, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia-Marie","family":"Petit","sequence":"additional","affiliation":[{"name":"Swiss Paediatric Liver Center, Paediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Paediatric Specialties, Department of Paediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, 6, Rue Willy-Donz\u00e9, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie A.","family":"McLin","sequence":"additional","affiliation":[{"name":"Swiss Paediatric Liver Center, Paediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Paediatric Specialties, Department of Paediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, 6, Rue Willy-Donz\u00e9, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5223\/pghn.2013.16.4.207","article-title":"Long term outcomes after pediatric liver transplantation","volume":"16","author":"Yazigi","year":"2013","journal-title":"Pediatr. 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