{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:05:18Z","timestamp":1784423118334,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Bronchiolitis may result in respiratory failure diagnosed with arterial blood gas (ABG). ABG is not routinely performed in general paediatric wards but is closely reflected by capillary blood gas (CBG). We sought to assess the usefulness of CBG results in prediction of intensive care unit (ICU) transfer, antibiotic treatment, and length of stay in children hospitalized due to bronchiolitis. Methods: The optimal cutoff values were estimated with an ROC analysis, while a multiple regression model calculated the odds of an ICU transfer, prolonged hospitalization, and antibiotic treatment related with hypercapnia (pCO2 \u2265 45 mmHg) and acidosis (pH \u2264 7.35). The correlation between the CBG (pH, pCO2, and SatO2) and the clinical\/laboratory parameters (breath rate, heart rate, pulse oximetry, white blood cells, CRP, and procalcitonin) was calculated. Results: The CBG was performed in 485 children aged 8 days\u201322 months (median 2 months). The pCO2 was significantly higher in ICU transferred patients (median 44.8 mmHg vs. 36.2 mmHg, p &lt; 0.01), and showed AUC = 0.773, (95% CI: 0.638\u20130.907, p &lt; 0.01) for ICU transfer (67% sensitivity, 82% specificity, 10.8% positive and 98.7% negative predictive value at cutoff 41.8 mmHg). Hypercapnia (OR = 6.63, 95% CI: 2.15\u201320.46, p &lt; 0.01) and acidosis (OR = 5.01, 95% CI: 1.26\u201319.9, p = 0.022) predicted the ICU transfer independently. The CBG parameters were not related to prolonged hospitalization or antibiotic treatment, and showed only a weak and clinically irrelevant correlation with other laboratory and clinical parameters. Conclusions: Acidosis and hypercapnia indicate patients at risk of an ICU transfer, and the pCO2 levels (including values lower than hypercapnia) seem to be a promising marker in ICU risk assessment.<\/jats:p>","DOI":"10.3390\/children8080719","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T10:24:17Z","timestamp":1629714257000},"page":"719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Capillary Blood Gas Predicts Risk of Intensive Care in Children with Bronchiolitis"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-3975","authenticated-orcid":false,"given":"August","family":"Wrotek","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99\/103, 01-813 Warsaw, Poland"},{"name":"Department of Pediatrics, Bielanski Hospital, Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Kobia\u0142ka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99\/103, 01-813 Warsaw, Poland"},{"name":"Department of Pediatrics, Bielanski Hospital, Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-7854","authenticated-orcid":false,"given":"Teresa","family":"Jackowska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99\/103, 01-813 Warsaw, Poland"},{"name":"Department of Pediatrics, Bielanski Hospital, Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1474","DOI":"10.1542\/peds.2014-2742","article-title":"Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis","volume":"134","author":"Ralston","year":"2014","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/INF.0b013e31829b7e43","article-title":"Viral Etiologies of Infant Bronchiolitis, Croup and Upper Respiratory Illness During 4 Consecutive Years","volume":"32","author":"Miller","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/5584_2019_391","article-title":"Antibiotic Treatment in Patients with Bronchiolitis","volume":"1211","author":"Wrotek","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1164\/rccm.202005-1660OC","article-title":"Live-attenuated Vaccines Prevent Respiratory Syncytial Virus\u2013associated Illness in Young Children","volume":"203","author":"Karron","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1553-2712.2008.00245.x","article-title":"Prospective Multicenter Bronchiolitis Study: Predicting Intensive Care Unit Admissions","volume":"15","author":"Damore","year":"2008","journal-title":"Acad. Emerg. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.3928\/19382359-20180625-01","article-title":"Acute Respiratory Failure in Children","volume":"47","author":"Friedman","year":"2018","journal-title":"Pediatr. Ann."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/adc.2002.016261","article-title":"Correlation of simultaneously obtained capillary, venous, and arterial blood gases of patients in a paediatric intensive care unit","volume":"89","author":"Yildizdas","year":"2004","journal-title":"Arch. Dis. Child."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1542\/peds.34.2.192","article-title":"The validity of pH and pCO2 measurements in capillary samples in sick and healthy newborn infants","volume":"34","author":"Gandy","year":"1964","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/00003246-200001000-00037","article-title":"Capillary blood gases in a pediatric intensive care unit","volume":"28","year":"2000","journal-title":"Crit. Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1097\/00003246-199711000-00032","article-title":"Comparison of simultaneously obtained arterial and capillary blood gases in pediatric intensive care unit patients","volume":"25","author":"Harrison","year":"1997","journal-title":"Crit. Care Med."},{"key":"ref_11","unstructured":"National Institute for Health and Care Excellence (Nice) (2021, June 20). Bronchiolitis in Children: Diagnosis and Management. Available online: https:\/\/www.nice.org.uk\/guidance\/ng9."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/pch\/19.9.485","article-title":"Drug Therapy and Hazardous Substances Committee Bronchiolitis: Recommendations for diagnosis, monitoring and management of children one to 24 months of age","volume":"19","author":"Friedman","year":"2014","journal-title":"Paediatr. Child Health"},{"key":"ref_13","first-page":"42","article-title":"Australasian bronchiolitis guideline","volume":"55","author":"Borland","year":"2018","journal-title":"J. Paediatr. Child Health"},{"key":"ref_14","unstructured":"Hryniewicz, W., Albrecht, P., and Radzikowski, A. (2021, June 20). Rekomendacje Post\u0119powania w Pozaszpitalnych Zaka\u017ceniach Uk\u0142adu Oddechowego. Available online: http:\/\/antybiotyki.edu.pl\/wp-content\/uploads\/Rekomendacje\/Rekomendacje2016.pdf."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"(2006). American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis Diagnosis and Management of Bronchiolitis. Pediatrics, 118, 1774\u20131793.","DOI":"10.1542\/peds.2006-2223"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ajem.2021.04.056","article-title":"Capillary blood gas in infants with bronchiolitis: Can end-tidal capnography replace it?","volume":"45","author":"Vo","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/BF02723794","article-title":"Comparison of blood gas values in arterial and venous blood","volume":"70","author":"Kirubakaran","year":"2003","journal-title":"Indian J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1001\/archpedi.1985.02140120065028","article-title":"Arterialized Capillary Blood Gases and Acid-Base Studies in Normal Individuals From 29 Days to 24 Years of Age","volume":"139","author":"Dong","year":"1985","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpedi.1990.02150260046025","article-title":"Capillary Blood Gases in the Neonate","volume":"144","author":"Courtney","year":"1990","journal-title":"Am. J. Dis. Child."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1136\/adc.44.238.726","article-title":"Comparison of arterial and arterialized capillary blood in infants with respiratory distress","volume":"44","author":"Banister","year":"1969","journal-title":"Arch. Dis. Child."},{"key":"ref_21","first-page":"567","article-title":"Reliability of capillary blood gas estimation in neonates","volume":"29","author":"Saili","year":"1992","journal-title":"Indian Pediatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1471-0528.1966.tb06080.x","article-title":"Comparison between Arterial, Capillary and Venous Acid-Base Measurements in the Newborn Infant","volume":"73","author":"Macrae","year":"1966","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/adc.63.7_Spec_No.743","article-title":"Comparison of capillary and arterial blood gas measurements in neonates","volume":"63","author":"McLain","year":"1988","journal-title":"Arch. Dis. Child."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0022-3476(78)80023-7","article-title":"Monitoring critically ill newborn infants with digital capillary blood samples: An alternative","volume":"92","author":"Karna","year":"1978","journal-title":"J. Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1542\/peds.51.3.501","article-title":"Capillary blood sampling in the infant: Usefulness and limitations of two methods of sampling, compared with arterial blood","volume":"51","author":"Hunt","year":"1973","journal-title":"Pediatrics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1542\/peds.46.5.780","article-title":"Oxygen tension measurements on digital blood in the newborn","volume":"46","author":"Corbet","year":"1970","journal-title":"Pediatrics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/00365516809076970","article-title":"The Validity of PO2Measurement in Capillary Blood as a Substitute for Arterial PO2","volume":"21","author":"Koch","year":"1968","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1164\/rccm.201812-2276ST","article-title":"Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline","volume":"199","author":"Hayes","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/thoraxjnl-2016-209729","article-title":"BTS guideline for oxygen use in adults in healthcare and emergency settings","volume":"72","author":"Howard","year":"2017","journal-title":"Thorax"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"136-A7","DOI":"10.12968\/hmed.2014.75.3.136","article-title":"Capillary blood gas as a substitute for arterial blood gas: A meta-analysis","volume":"75","author":"Richter","year":"2014","journal-title":"Br. J. Hosp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/thx.49.4.364","article-title":"Arterialised earlobe blood gas analysis: An underused technique","volume":"49","author":"Pitkin","year":"1994","journal-title":"Thorax"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/adc.2005.091231","article-title":"Randomised controlled trial of nasal continuous positive airways pressure (CPAP) in bronchiolitis","volume":"93","author":"Thia","year":"2008","journal-title":"Arch. Dis. Child."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/8\/719\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:49:49Z","timestamp":1760165389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/8\/719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["children8080719"],"URL":"https:\/\/doi.org\/10.3390\/children8080719","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]}}}