{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:12:42Z","timestamp":1774321962489,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Functional gastrointestinal disorders (FGIDs) are chronic and recurrent disorders, which affect up to 23% of children and adolescents and represent 50% of gastroenterological accesses. The association between FGIDs diagnosed at paediatric age and the onset of migraine or headache and neuropsychiatric diseases in adolescence and adulthood is widely reported in the literature. However, there is still limited knowledge about the long-term prognosis and risk factors for neuropsychiatric pathologies and other comorbidities. Aim: The aim is to assess the prevalence and persistence of FGIDs as well as the occurrence of migraine or headache and neuropsychiatric disorders in a cohort of patients diagnosed with FGIDs 15 years ago compared with a control group of peers. Materials and methods: We enrolled a group of patients diagnosed with FGIDs at paediatric age, at least 10 years ago (FGIDs group, n = 79; median age 23), and control subjects (control group, n = 201; median age 23). In both groups, an online questionnaire created explicitly for the study was submitted in order to investigate the presence of chronic intestinal diseases, migraine, headache or neuropsychiatric disorders. Results: 45.6% (36 out of 79) of patients previously diagnosed with FGIDs still suffer from FGIDs versus 12% (24 out of 201) of healthy controls (p &lt; 0.0001). The prevalence of chronic organic gastrointestinal disorders was comparable in the two groups (2.5% in FGIDs group versus 1% in healthy group, p = 0.3). Thirty-three percent (26 out of 79) of FGIDs patients reported headache or migraine versus 13% (26 out of 201) of healthy peers (p &lt; 0.001). No differences were found regarding the prevalence of anxiety and depression. Conclusion: The outcome at 15 years of FGIDs was characterized by a high prevalence of persisting functional symptoms along with a significant incidence of headaches and migraines. Abbreviation: FGIDs: Functional gastrointestinal disorders; IBS: Inflammatory Bowel Syndrome.<\/jats:p>","DOI":"10.3390\/children8100838","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:15:32Z","timestamp":1632514532000},"page":"838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fifteen-Years Follow-Up in a Cohort of Children with Functional Gastrointestinal Disorders: Prevalence and Risk Factors to Develop Neuropsychiatric Disorders and Other Comorbidities"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-1963","authenticated-orcid":false,"given":"Chiara","family":"Zanchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Institute for Maternal and Child Health \u201cIRCCS Burlo Garofolo\u201d, Via dell\u2019Istria 65, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Pintaldi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute for Maternal and Child Health \u201cIRCCS Burlo Garofolo\u201d, Via dell\u2019Istria 65, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-3914","authenticated-orcid":false,"given":"Luca","family":"Ronfani","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health \u201cIRCCS Burlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4949-3219","authenticated-orcid":false,"given":"Giulia","family":"Zamagni","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health \u201cIRCCS Burlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Viel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-846X","authenticated-orcid":false,"given":"Egidio","family":"Barbi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute for Maternal and Child Health \u201cIRCCS Burlo Garofolo\u201d, Via dell\u2019Istria 65, 34137 Trieste, Italy"},{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute for Maternal and Child Health \u201cIRCCS Burlo Garofolo\u201d, Via dell\u2019Istria 65, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S2468-1253(16)30038-3","article-title":"Association between functional gastrointestinal disorders and migraine in children and adolescents: A case-control study","volume":"1","author":"Michel","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics Subcommittee on Chronic Abdominal Pain and NASPGHAN Committee on Abdominal Pain (2005). Chronic Abdominal Pain in Children: A Clinical Report of the American Academy of Pediat-rics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. JPGN, 40, 245\u2013248.","DOI":"10.1097\/01.MPG.0000155367.44628.21"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10802-012-9657-0","article-title":"Functional Gastrointestinal symptoms in children with anxiety dosorderes","volume":"41","author":"Waters","year":"2013","journal-title":"J. Abnorm. Child Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0140-6736(20)32115-2","article-title":"Functional gastrointestinal Disorders: Advances in under-standing and management","volume":"21","author":"Black","year":"2020","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5223\/pghn.2017.20.1.1","article-title":"The New Rome IV Criteria for Functional Gastrointestinal Disor-ders in Infants and Toddlers","volume":"20","author":"Zeevenhooven","year":"2017","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1136\/gutjnl-2019-318308","article-title":"Role of brain imaging in disorders of brain\u2013gut interaction: A Rome Working Team Report","volume":"68","author":"Mayer","year":"2019","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/nmo.12793","article-title":"Functional neuroimaging studies in functional dyspepsia patients: A systematic review","volume":"28","author":"Lee","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.cgh.2016.12.032","article-title":"Mood and anxiety disorders pre-cede development of functional gastrointestinal disorders in patients but not in the population","volume":"15","author":"Jones","year":"2017","journal-title":"Clin. Gastroen-terol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/apt.13738","article-title":"Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: A 1-year population-based prospective study","volume":"44","author":"Koloski","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.cgh.2014.03.034","article-title":"Predicting Persistence of Functional Abdominal Pain From Childhood Into Young Adulthood","volume":"12","author":"Horst","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1096\/fasebj.3.2.2464517","article-title":"Role of the \u2018\u2018little brain\u2019\u2019 in the gut in water and electrolyte homeostasis","volume":"3","author":"Cooke","year":"1989","journal-title":"FASEB J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1176\/appi.psy.48.2.93","article-title":"Functional Gastrointestinal Disorders: An Update for the Psychiatrist","volume":"48","author":"Jones","year":"2007","journal-title":"J. Psychosom. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2036.2008.03813.x","article-title":"Fluctuation of gastrointestinal symptoms in the com-munity: A 10\u00acyear longitudinal follow-up study","volume":"28","author":"Ford","year":"2008","journal-title":"Aliment Pharmacol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1053\/j.gastro.2015.01.039","article-title":"Anxiety Is Linked to New-Onset Dyspepsia in the Swedish Population: A 10-Year Follow-up Study","volume":"148","author":"Aro","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.gastro.2007.06.010","article-title":"Natural history of functional gastrointestinal disorders: A 12-year longitudinal population\u00acbased study","volume":"133","author":"Halder","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2016.02.015","article-title":"Childhood Functional Gastrointestinal Disorders: Child\/Adolescent","volume":"150","author":"Hyams","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8149","DOI":"10.3748\/wjg.v22.i36.8149","article-title":"Gastrointestinal disorders associated with migraine: A comprehensive review","volume":"22","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.npep.2013.10.010","article-title":"CGRP and migraine: Could PACAP play a role too?","volume":"47","author":"Kaiser","year":"2013","journal-title":"Neuropeptides"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.npep.2010.06.004","article-title":"Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice","volume":"44","author":"Kormos","year":"2010","journal-title":"Neuropeptides"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1053\/j.gastro.2005.09.031","article-title":"Altered 5-hydroxytryptamine signaling in pa-tients with constipation- and diarrhea-predominant irritable bowel syndrome","volume":"130","author":"Atkinson","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cgh.2013.03.026","article-title":"Decreased Basal and Postprandial Plasma Serotonin Levels in Patients with Functional Dyspepsia","volume":"11","author":"Cheung","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/0883073809336875","article-title":"Efficacy of sumatriptan in two pediatric cases with abdominal pain-related functional gastrointestinal disorders: Does the mechanism overlap that of migraine?","volume":"25","author":"Kakisaka","year":"2010","journal-title":"J. Child Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13052-014-0092-4","article-title":"Pediatric migraine and episodic syndromes that may be associated with mi-graine","volume":"40","author":"Spiri","year":"2014","journal-title":"Ital. J. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.5009\/gnl.2013.7.6.668","article-title":"Concomitant functional gastrointestinal symptoms in-fluence psychological status in Korean migraine patients","volume":"7","author":"Park","year":"2013","journal-title":"Gut Liver"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2019686","DOI":"10.1001\/jamanetworkopen.2020.19686","article-title":"Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 Pandemic","volume":"3","author":"Ettman","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Basheti, I.A., Mhaidat, Q.N., and Mhaidat, H.N. (2021). Prevalence of anxiety and depression during COVID-19 pandemic among healthcare students in Jordan and its effect on their learning process: A national survey. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249716"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hawes, M.T., Szenczy, A.K., Klein, D.N., Hajcak, G., and Nelson, B.D. (2021). Increases in depression and anxiety symptoms in adolescents and young adults during the COVID-19 pandemic. Psychol. Med., 1\u20139.","DOI":"10.1017\/S0033291720005358"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/10\/838\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:04:16Z","timestamp":1760166256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/10\/838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,24]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["children8100838"],"URL":"https:\/\/doi.org\/10.3390\/children8100838","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,24]]}}}