{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:25:53Z","timestamp":1760235953937,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Research Foundation of Korea","award":["NRF-2018R1A5A2024418 and NRF-2020R1A2C2100543"],"award-info":[{"award-number":["NRF-2018R1A5A2024418 and NRF-2020R1A2C2100543"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Recently, a new type of dental anomaly, a molar\u2013incisor malformation or molar root\u2013incisor malformation (MRIM), was recognized. The disease phenotype is now relatively well characterized; however, its etiology and disease-mechanism need to be elucidated. The affected teeth do not respond well to conventional treatment because of severe malformation and an unusual root structure. In this study, we present the treatment of MRIM cases with the extraction of severely aberrant permanent first molars (PFMs) and suggest that the PFM extractions are performed when it is clear that third molars will develop. The purpose of this report was primarily to present amendments to the guidelines for the treatment of patients with MRIM.<\/jats:p>","DOI":"10.3390\/children8100904","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T09:16:42Z","timestamp":1633943802000},"page":"904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Management of Severely Aberrant Permanent First Molars in Molar Root\u2013Incisor Malformation Patients: Case Series and a Guideline"],"prefix":"10.3390","volume":"8","author":[{"given":"Ji-Soo","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon-Mi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Chonbuk National University, Jeonju-si 54896, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-2197","authenticated-orcid":false,"given":"Jung-Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea"},{"name":"Department of Molecular Genetics, School of Dentistry & DRI, Seoul National University, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1016\/j.oooo.2013.06.030","article-title":"Root malformation associated with a cervical mineralized diaphragm--a distinct form of tooth abnormality?","volume":"117","author":"Witt","year":"2014","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.oooo.2014.03.014","article-title":"A new type of dental anomaly: Molar-incisor malformation (MIM)","volume":"118","author":"Lee","year":"2014","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.oooo.2017.03.050","article-title":"Molar incisor malformation in six cases: Description and diagnostic protocol","volume":"124","author":"Brusevold","year":"2017","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_4","first-page":"33","article-title":"Molar-incisor Malformation: Two Cases of a Newly Described Dental Anomaly","volume":"83","author":"McCreedy","year":"2016","journal-title":"J. Dent. Child."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/1465312519875973","article-title":"Molar-incisor malformation: A case report and clinical considerations","volume":"46","author":"Neo","year":"2019","journal-title":"J. Orthod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/ipd.12592","article-title":"Molar-incisor malformation: Eight new cases and a review of the literature","volume":"30","author":"Vargo","year":"2020","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.oooo.2015.08.024","article-title":"Molar root-incisor malformation: Considerations of diverse developmental and etiologic factors","volume":"121","author":"Wright","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1016\/j.oooo.2016.11.024","article-title":"Symmetric multiquadrant isolated dentin dysplasia (SMIDD), a unique presentation mimicking dentin dysplasia type 1b","volume":"123","author":"Qari","year":"2017","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fphys.2015.00307","article-title":"Malformations of the tooth root in humans","volume":"6","author":"Luder","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.oooo.2014.10.013","article-title":"Microscopic analysis of molar-incisor malformation","volume":"119","author":"Lee","year":"2015","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.archoralbio.2017.04.009","article-title":"Variable expressivity of TCTEX1D2 mutations and a possible pathogenic link of molar-incisor malformation to ciliary dysfunction","volume":"80","author":"Zschocke","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pavli\u010d, A., Vrecl, M., Jan, J., Bizjak, M., and Nemec, A. (2019). Case report of a molar-root incisor malformation in a patient with an autoimmune lymphoproliferative syndrome. BMC Oral Health, 19.","DOI":"10.1186\/s12903-019-0739-z"},{"key":"ref_13","first-page":"238","article-title":"Treatment of Molar Incisor Malformation and the short term follow-up: Case reports","volume":"21","author":"Park","year":"2020","journal-title":"Eur. J. Paediatr. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.joen.2015.11.004","article-title":"Nonsurgical Endodontic Management of a Molar-Incisor Malformation-affected Mandibular First Molar: A Case Report","volume":"42","author":"Yue","year":"2016","journal-title":"J. Endod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e17356","DOI":"10.1097\/MD.0000000000017356","article-title":"Clinico-radiologic features of molar-incisor malformation in a case series of 38 patients: A retrospective observational study","volume":"98","author":"Kim","year":"2019","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lee, H.-S., Kim, H.J., Lee, K., Kim, M.S., Nam, O.H., and Choi, S.-C. (2021). Complications of Teeth Affected by Molar-Incisor Malformation and Pathogenesis According to Microbiome Analysis. Appl. Sci., 11.","DOI":"10.3390\/app11010004"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/10\/904\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:11:39Z","timestamp":1760166699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/10\/904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["children8100904"],"URL":"https:\/\/doi.org\/10.3390\/children8100904","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2021,10,11]]}}}