{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T04:20:29Z","timestamp":1765772429205,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Optimal starting oxygen concentration for delivery room resuscitation of extremely preterm infants (&lt;29 weeks) remains unknown, with recommendations of 21\u201330% based on uncertain evidence. Individual patient randomized trials designed to answer this question have been hampered by poor enrolment. Hypothesis: It is feasible to compare 30% vs. 60% starting oxygen for delivery room resuscitation of extremely preterm infants using a change in local hospital policy and deferred consent approach. Study design: Prospective, single-center, feasibility study, with each starting oxygen concentration used for two months for all eligible infants. Population: Infants born at 23 + 0\u201328 + 6 weeks\u2019 gestation who received delivery room resuscitation. Study interventions: Initial oxygen at 30% or 60%, increasing by 10\u201320% every minute for heart rate &lt; 100 bpm, or increase to 100% for chest compressions. Primary outcome: Feasibility, defined by (i) achieving difference in cumulative supplied oxygen concentration between groups, and (ii) post-intervention rate consent &gt;50%. Results: Thirty-four infants were born during a 4-month period; consent was obtained in 63%. Thirty (n = 12, 30% group; n = 18, 60% group) were analyzed, including limited data from eight who died or were transferred before parents could be approached. Median cumulative oxygen concentrations were significantly different between the two groups in the first 5 min. Conclusion: Randomized control trial of 30% or 60% oxygen at the initiation of resuscitation of extremely preterm neonates with deferred consent is feasible. Trial registration: Clinicaltrials.gov NCT03706586<\/jats:p>","DOI":"10.3390\/children8110942","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T07:05:57Z","timestamp":1634713557000},"page":"942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Higher versus Lower Oxygen Concentration during Respiratory Support in the Delivery Room in Extremely Preterm Infants: A Pilot Feasibility Study"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-9253","authenticated-orcid":false,"given":"Brenda","family":"Law","sequence":"first","affiliation":[{"name":"Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Alberta Health Services, Edmonton, AB T5H 3V9, Canada"},{"name":"Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Asztalos","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre, Department of Paediatrics, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Finer","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Diego, CA 92093, USA"},{"name":"Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA 92123, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryna","family":"Yaskina","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Institute, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-4742","authenticated-orcid":false,"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[{"name":"Health Research Centre, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain"},{"name":"Division of Neonatology, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain"},{"name":"Spanish Maternal and Infant Health and Development Network, Health Research Institute Carlos III, National Network, 46026 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Tarnow-Mordi","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakesh","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-2415","authenticated-orcid":false,"given":"Georg","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[{"name":"Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Alberta Health Services, Edmonton, AB T5H 3V9, Canada"},{"name":"Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0004-8666.2002.00119.x","article-title":"Update on intrapartum fetal pulse oximetry","volume":"42","author":"East","year":"2002","journal-title":"Aust. 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