{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:09:00Z","timestamp":1788905340676,"version":"build-2803163510"},"reference-count":17,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background and Objectives: Osteogenesis imperfecta is a rare pathology involving the bones and the connective tissues, generating alterations that lead to frequent fractures during childhood. When fractures occur at birth, they are associated with an impairment of walking and the quality of life. Although surgical techniques have significantly improved in recent years, functional outcomes and the quality of life for pediatric patients that benefited from surgical management with telescopic rods have been less evaluated. This study aimed to measure functional results and determine the factors that influence the quality of life for the pediatric population diagnosed with Osteogenesis imperfecta and surgically treated using the telescopic rod approach after suffering a fracture or severe deformity. Materials and Methods: We conducted a cohort study that consisted of 15 patients diagnosed with Osteogenesis imperfecta (average age of 11.6 years). All individuals possessed at least one intramedullary telescopic rod as a result of the surgical treatment. Results: We observed that the pain, both acute and chronic, impairs the quality of life and interferes with daily living activities, for instance, self-care tasks. Conclusions: Osteogenesis imperfecta is associated with a severely damaged level of walking. All of the aspects of the pediatric patient\u2019s daily life activity seem to be affected. Furthermore, these patients, especially those residing in rural areas, have a poor quality of life.<\/jats:p>","DOI":"10.3390\/children8111066","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T02:43:09Z","timestamp":1637289789000},"page":"1066","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the Functional Outcomes and the Quality of Life for Pediatric Patients with Osteogenesis Imperfecta after Fracture Treatment with Intramedullary Rodding"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-2561","authenticated-orcid":false,"given":"Alexandru","family":"Herdea","sequence":"first","affiliation":[{"name":"11th Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Pediatric Orthopedics Department, \u201cGrigore Alexandrescu\u201d Children\u2019s Emergency Hospital, 011743 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-1506","authenticated-orcid":false,"given":"Alexandru","family":"Ulici","sequence":"additional","affiliation":[{"name":"11th Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Pediatric Orthopedics Department, \u201cGrigore Alexandrescu\u201d Children\u2019s Emergency Hospital, 011743 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7339-8273","authenticated-orcid":false,"given":"Dimitra","family":"Qirjako","sequence":"additional","affiliation":[{"name":"11th Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan Petru","family":"Derihaci","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Carl Gustav Carus, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-3142","authenticated-orcid":false,"given":"Claudiu N.","family":"Lungu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Country Emergency Hospital Br\u0103ila, 810249 Br\u0103ila, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-4393","authenticated-orcid":false,"given":"Adham","family":"Charkaoui","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","unstructured":"Antoniazzi, F., Mottes, M., Fraschini, P., Brunelli, P.C., and Tat\u00f2, L. (2012). Osteogenesis Imperfecta, Practical Treatment Guidelines, Pediatric Drugs, Springer International Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hefti, F. (2015). Pediatric Orthopedics in Practice, Springer.","DOI":"10.1007\/978-3-662-46810-4"},{"key":"ref_3","unstructured":"Ramachandran, M., Achan, P., Jones, D.H.A., and Panchbhavi, V.K. (2018). Osteogenesis Imperfecta, Medscape."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0022-3476(87)80138-5","article-title":"Osteocalcin levels in osteogenesis imperfecta","volume":"111","author":"Rico","year":"1987","journal-title":"J. Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1651-2227.1998.tb00920.x","article-title":"Collagen-derived markers of bone metabolism in osteogenesis imperfecta","volume":"87","author":"Lund","year":"1998","journal-title":"Acta Paediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01241398-198507000-00014","article-title":"Consequences of an osteogenesis imperfecta diagnosis for survival and ambulation","volume":"5","author":"Shapiro","year":"1985","journal-title":"J. Pediatric Orthop."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/adc.80.6.524","article-title":"Anthropometry of patients with osteogenesis imperfecta","volume":"80","author":"Lund","year":"1999","journal-title":"Arch. Dis. Child."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00003086-198109000-00015","article-title":"Nonoperative treatment of osteogenesis imperfecta: Orthotic and mobility management","volume":"159","author":"Bleck","year":"1981","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_9","unstructured":"(2003). Pain Intensity Instruments."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Cech, D.J., and Martin, S.T. (2012). Functional Movement Development across the Life Span, Chapter 5 Evaluation of Function, Activity, and Participation, Elsevier.","DOI":"10.1016\/B978-1-4160-4978-4.00005-3"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1067\/mpd.2000.107892","article-title":"Osteogenesis imperfecta in childhood: Prognosis for walking","volume":"137","author":"Raoul","year":"2000","journal-title":"J. Pediatrics"},{"key":"ref_12","unstructured":"Shapiro, J.R., Byers, P.H., Glorieux, F.H., and Sponsellor, P.D. (2014). Osteogenesis Imperfecta, A Translational Approach to Brittle Bone Disease, Elsevier."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0003-9993(97)90009-5","article-title":"Predicting patient scores between the functional independence measure and the minimum data set: Development and performance of a FIM-MDS \u201ccrosswal\u201d","volume":"78","author":"Williams","year":"1997","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Widmann, R.F., Laplaza, J.F., and Bitan, F.D. (2001). Catherine E Brooks & Leon Root: Quality Of Life in Osteogenesis Imperfecta, Springer Nature. International Orthopaedics (SICOT) 26.","DOI":"10.1007\/s002640100292"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00001577-199700910-00004","article-title":"Functional Outcome in Osteogenesis Imperfecta: Disability Profiles Using the PEDI","volume":"9","author":"Engelbert","year":"1997","journal-title":"Pediatric Phys. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Herdea, A., Ulici, A., Toma, A., Voicu, B., and Charkaoui, A. (2021). The Relationship between the Dominant Hand and the Occurrence of the Supracondylar Humerus Fracture in Pediatric Orthopedics. Children, 8.","DOI":"10.3390\/children8010051"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/ortho.IJOrtho_442_17","article-title":"Nursemaid\u2019s Elbow-Supination-flexion Technique Versus Hyperpronation\/forced Pronation: Randomized Clinical Study","volume":"53","author":"Ulici","year":"2019","journal-title":"Indian J. Orthop."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/11\/1066\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:32:34Z","timestamp":1760167954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/11\/1066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["children8111066"],"URL":"https:\/\/doi.org\/10.3390\/children8111066","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,19]]}}}