{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:34:31Z","timestamp":1760236471474,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The therapy of patients with Crouzon syndrome involves a multidisciplinary team. In most cases, this therapy is extensive, time-consuming, and exhausting for the patient. This case report illustrates a temporally coordinated therapy plan that succeeds in reducing the burden of care. Showing typical extraoral characteristics of Crouzon syndrome, the patient had a frontal and left-sided crossbite, and impaction of the maxillary canines. Multidisciplinary therapy included the extraction of multiple teeth, midface distraction at Le Fort III level, and alignment of the impacted teeth. Before starting, during, and after completion of the treatment, the patient\u2019s oral health-related quality of life was assessed using COHIP-19. The combination of different treatment steps significantly reduced the duration of therapy. The therapy improved not only the patient\u2019s oro- and craniofacial function, but also the patient\u2019s facial appearance in a short treatment period. The patient\u2019s quality of life improved considerably during this time. In the treatment of severe craniofacial anomalies, the highest priority should be given to keeping the burden of care low. All measures should encourage young patients\u2019 appropriate psychosocial development despite extensive therapies, ensuring at the same time medically satisfactory treatment results.<\/jats:p>","DOI":"10.3390\/children8121122","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T20:59:33Z","timestamp":1638737973000},"page":"1122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reducing the Burden of Care: Multidisciplinary Management of Late-Manifested Crouzon Syndrome\u2014A Case Report"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-6329","authenticated-orcid":false,"given":"Sarah","family":"Achterrath","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"},{"name":"Center for Rare Orofacial and Craniofacial Malformations, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-7749","authenticated-orcid":false,"given":"Teresa","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"},{"name":"Center for Rare Orofacial and Craniofacial Malformations, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Neuschulz","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"},{"name":"Center for Rare Orofacial and Craniofacial Malformations, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"},{"name":"Center for Rare Orofacial and Craniofacial Malformations, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Z\u00f6ller","sequence":"additional","affiliation":[{"name":"Center for Rare Orofacial and Craniofacial Malformations, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"},{"name":"Department of Oral and Craniomaxillofacial and Plastic Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Braumann","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"},{"name":"Center for Rare Orofacial and Craniofacial Malformations, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, North Rhine Westphalia, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1399-0004.1992.tb03620.x","article-title":"Birth prevalence studies of the Crouzon syndrome: Comparison of direct and indirect methods","volume":"41","author":"Cohen","year":"1992","journal-title":"Clin. 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