{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:41:35Z","timestamp":1792698095809,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>A giant cell tumor (GCT) of the bone is characteristically found in skeletally mature patients. The tumor is rare in pediatric patients, and incidence reported in literature varies from 1.8% to 10.6%. We performed a retrospective study addressing symptoms, treatment, and outcome in pediatric patients who were diagnosed with GCT between March 1997 and January 2015 at our hospital. Fourteen (11.1%) of 126 surgically treated patients with histologically proven GCT were &lt;19 years of age. We confirmed skeletal maturity using magnetic resonance imaging (MRI). Fourteen patients from 8 to 19 years old were identified. Sixteen lesions (76.2%) were found in long bones and 5 lesions (23.8%) in short bones. The most common site was around the knee in 8 patients (38%). GCTs mostly occur at the epi-metaphysis in 11 patients (52.3%). Regardless of the openness of epiphyseal plate, we observed GCT of bone in the epiphysis. Further study will be needed to prove the association between the presence of epiphyseal plate and location of tumor. Three patients (21.4%) had multicentric lesions, and four patients (28.5%) had local recurrence. Multicentric giant cell tumor and local recurrence occur more often in pediatric patients. The characteristics of GCT in pediatric patients do not differ from what is reported for GCT in adults.<\/jats:p>","DOI":"10.3390\/children8121157","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:52:32Z","timestamp":1639086752000},"page":"1157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics of Giant Cell Tumor of the Bone in Pediatric Patients: Our 18-Year, Single-Center Experience"],"prefix":"10.3390","volume":"8","author":[{"given":"Woo-Jong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-9503","authenticated-orcid":false,"given":"Sungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Woong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil-Hwan","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-9799","authenticated-orcid":false,"given":"Sung-Taek","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"ref_1","first-page":"35","article-title":"Giant cell tumor of bone","volume":"37","author":"Turcotte","year":"2006","journal-title":"Orthop. Clin."},{"key":"ref_2","unstructured":"Board, W. (2020). Soft Tissue and Bone Tumours: International Agency for Research on Cancer, IARC."},{"key":"ref_3","first-page":"173","article-title":"Giant cell tumor in children and adolescents","volume":"22","author":"Taconis","year":"1993","journal-title":"Skelet. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2106\/00004623-198365040-00009","article-title":"Giant-cell tumor of bone in skeletally immature patients","volume":"65","author":"Picci","year":"1983","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1148\/radiology.184.1.1609086","article-title":"Giant cell tumor in skeletally immature patients","volume":"184","author":"Kransdorf","year":"1992","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/BPO.0b013e3181425629","article-title":"Giant cell tumor of bone in children and adolescents","volume":"27","author":"Puri","year":"2007","journal-title":"J. Pediatr. Orthop."},{"key":"ref_7","first-page":"1998","article-title":"Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases","volume":"88","author":"Hoch","year":"2006","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2106\/00004623-198769010-00018","article-title":"Giant-cell tumor of bone","volume":"69","author":"Campanacci","year":"1987","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"key":"ref_9","unstructured":"Unni, K.K., Inwards, C.Y., and Research, M. (2010). Dahlin\u2019s Bone Tumors: General Aspects and Data on 10,165 Cases: Wollters Kluwer Health, Lippincott Williams & Wilkins."},{"key":"ref_10","unstructured":"Huvos, A.G. (1991). Bone Tumors: Diagnosis, Treatment, and Prognosis, Saunders."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0165-4608(92)90125-R","article-title":"Giant cell tumor of bone. Chromosomal analysis of 48 specimens and review of the literature","volume":"58","author":"Bridge","year":"1992","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_12","first-page":"29","article-title":"Metaphyseal and diaphyseal localization of giant cell tumors","volume":"62","author":"Campanacci","year":"1975","journal-title":"Chir. Organi Mov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2106\/00004623-197052040-00001","article-title":"Giant-cell tumor of bone. An analysis of two hundred and eighteen cases","volume":"52","author":"Goldenberg","year":"1970","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11914-017-0380-1","article-title":"Denosumab: An Emerging Therapy in Pediatric Bone Disorders","volume":"15","author":"Boyce","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2214\/ajr.144.5.955","article-title":"Caldwell lecture. Giant Cell Tumor: Highlights of 407 Cases","volume":"144","author":"Dahlin","year":"1985","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/17453678408992339","article-title":"Favourable results of acrylic cementation for giant cell tumors","volume":"55","author":"Persson","year":"1984","journal-title":"Acta Orthop. Scand."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2106\/00004623-199311000-00009","article-title":"Intralesional excision compared with en bloc resection for giant-cell tumors of bone","volume":"75","author":"Gitelis","year":"1993","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.2106\/00004623-199412000-00009","article-title":"Recurrence of giant-cell tumors of the long bones after curettage and packing with cement","volume":"76","author":"Springfield","year":"1994","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"key":"ref_19","first-page":"531","article-title":"Treatment of local recurrences of giant cell tumour in long bones after curettage and cementing. A Scandinavian Sarcoma Group study","volume":"88","author":"Bauer","year":"2006","journal-title":"J. Bone Jt. Surg. Br. Vol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/1097-0142(196207\/08)15:4<653::AID-CNCR2820150402>3.0.CO;2-M","article-title":"Benign and malignant giant cell tumors of bone. A clinicopathological analysis of the natural history of the disease","volume":"15","author":"Hutter","year":"1962","journal-title":"Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1302\/0301-620X.54B2.216","article-title":"Giant-cell tumour of bone: An analysis of fifty-two cases","volume":"54","author":"McGrath","year":"1972","journal-title":"J. Bone Jt. Surg. Br. Vol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/1097-0142(197005)25:5<1061::AID-CNCR2820250509>3.0.CO;2-E","article-title":"Giant-cell tumor: A study of 195 cases","volume":"25","author":"Dahlin","year":"1970","journal-title":"Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jaffe, H.L. (1958). Tumors and Tumorous Conditions of the Bones and Joints, Lea & Febiger.","DOI":"10.1097\/00001888-195901000-00023"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ajpath.2010.11.035","article-title":"Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis","volume":"178","author":"Conti","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ambrosi, F., Righi, A., Benini, S., Magagnoli, G., Chiaramonte, I., Manfrini, M., Gasbarrini, A., Frisoni, T., and Gambarotti, M. (2021). Giant Cell Tumor of Bone in Patients under 16 Years Old: A Single-Institution Case Series. Cancers, 13.","DOI":"10.3390\/cancers13112585"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4055\/cios.2012.4.2.107","article-title":"Modern interpretation of giant cell tumor of bone: Predominantly osteoclastogenic stromal tumor","volume":"4","author":"Kim","year":"2012","journal-title":"Clin. Orthop. Surg."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/12\/1157\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:43:20Z","timestamp":1760168600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/12\/1157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["children8121157"],"URL":"https:\/\/doi.org\/10.3390\/children8121157","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]}}}