{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:10:09Z","timestamp":1792804209547,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Marseille Public University Hospital System","award":["AORC 2009"],"award-info":[{"award-number":["AORC 2009"]}],"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Uni-modal orofacial stimulation (OFS) for preventing very preterm infants\u2019 oral disorders is highly controversial. Our study sought to demonstrate that OFS reduced cardio-respiratory events and improved food autonomy in a population of very preterm infants. Our study was randomized, controlled, prospective, and unicentric. The preterm included were born between 26\u201329 weeks gestational age (GA) with a corrected postnatal age &lt;33 weeks GA. They were randomized into two groups: the experimental group underwent OFS, according to a protocol established, over 10 consecutive days, and the control group underwent no OFS. The primary outcome was the number of cardiorespiratory events: apnea\u2013bradycardia (with or without desaturations) or number of isolated desaturations, which were evaluated at four separate times. Measurements occurred during the first, fourth and eighth independent feedings. Seventeen patients were included in the experimental group and 18 in the control group. The number of cardiorespiratory events for all independent feeding times was significantly reduced in the OFS group (p = 0.003) with univariate analysis, but not with multivariable analysis. The quantity of milk ingested during the first autonomous feeding was higher in the experimental group. The acquisition of food autonomy and the duration of hospitalization were similar in the two groups. While our study does not affirm that an early unimodal OFS improves premature infants\u2019 cardiorespiratory evolution and\/or the acquisition of food autonomy, it does indicate an improved food efficiency during their first autonomous feedings.<\/jats:p>","DOI":"10.3390\/children8121188","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:27:36Z","timestamp":1639654056000},"page":"1188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardio-Respiratory Events and Food Autonomy Responses to Early Uni-Modal Orofacial Stimulation in Very Premature Babies: A Randomized, Controlled Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Sahra","family":"M\u00e9ziane","sequence":"first","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Br\u00e9vaut-Malaty","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-9633","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Garbi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Busuttil","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Sorin","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-9944","authenticated-orcid":false,"given":"Barth\u00e9l\u00e9my","family":"Tosello","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"},{"name":"CNRS, EFS, ADES, Aix-Marseille University, 13344 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gire","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France"},{"name":"CEReSS-Health Service Research and Quality of Life Center, Aix-Marseille University, 27 Boulevard Jean Moulin, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arcped.2014.11.016","article-title":"Course and neurological\/behavioral development of preterm children","volume":"22","author":"Marret","year":"2015","journal-title":"Arch. Pediatrie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1651-2227.2003.tb00607.x","article-title":"Coordination of suck-swallow and swallow respiration in preterm infants","volume":"92","author":"Lau","year":"2007","journal-title":"Acta Paediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000321987","article-title":"A Novel Approach to Assess Oral Feeding Skills of Preterm Infants","volume":"100","author":"Lau","year":"2011","journal-title":"Neonatology"},{"key":"ref_4","first-page":"CD001071","article-title":"Non-nutritive sucking for promoting physiologic stability and nutrition in preterm infants","volume":"19","author":"Pinelli","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1055\/s-0038-1667289","article-title":"Non-Nutritive Sucking in the Preterm Infant","volume":"36","author":"Pineda","year":"2019","journal-title":"Am. J. Perinatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1067\/mpd.2002.125731","article-title":"Oral stimulation accelerates the transition from tube to oral feeding in preterm infants","volume":"141","author":"Fucile","year":"2002","journal-title":"J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/sj.jp.7200101","article-title":"Developmental care teams in the neonatal intensive care unit: Survey on current status","volume":"19","author":"Ashbaugh","year":"1999","journal-title":"J. Perinatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0929-693X(00)80127-X","article-title":"Evaluation of the quality of life of infants and very young children: Validation of a questionnaire. Multicenter European study","volume":"7","author":"Manificat","year":"2000","journal-title":"Arch Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.earlhumdev.2018.04.016","article-title":"Effects of early intervention on feeding behavior in preterm infants: A randomized controlled trial","volume":"121","author":"Fontana","year":"2018","journal-title":"Early Hum. Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.infbeh.2008.09.004","article-title":"Effectiveness of a Modified Mother\u2013Infant Transaction Program on Outcomes for Preterm Infants from 3 to 24 months of age","volume":"32","author":"Newnham","year":"2009","journal-title":"Infant Behav. Dev."},{"key":"ref_11","first-page":"CD000390","article-title":"Massage for promoting growth and development of preterm and\/or low birth-weight infants","volume":"2004","author":"Vickers","year":"2004","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/ANC.0000000000000166","article-title":"Multisensory Intervention for Preterm Infants Improves Sucking Organization","volume":"15","author":"Rankin","year":"2015","journal-title":"Adv. Neonatal Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12098-012-0945-z","article-title":"Effect of Multisensory Stimulation on Neuromotor Development in Preterm Infants","volume":"80","author":"Kanagasabai","year":"2013","journal-title":"Indian J. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5014\/ajot.50.3.184","article-title":"The Effects of a Prefeeding Stimulation Program on Preterm Infants","volume":"50","author":"Gaebler","year":"1996","journal-title":"Am. J. Occup. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1469-8749.2011.04023.x","article-title":"Oral and non-oral sensorimotor interventions enhance oral feeding performance in preterm infants: Oral Feeding Following Sensorimotor Interventions","volume":"53","author":"Fucile","year":"2011","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_16","first-page":"138","article-title":"The effect of music reinforcement for non-nutritive sucking on nipple feeding of premature infants","volume":"36","author":"Standley","year":"2010","journal-title":"Pediatr. Nurs."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1017\/S0012162205000290","article-title":"Effect of an oral stimulation program on sucking skill maturation of preterm infants","volume":"47","author":"Fucile","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_18","first-page":"CD009720","article-title":"Oral stimulation for promoting oral feeding in preterm infants","volume":"9","author":"Greene","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0022-3476(99)70231-3","article-title":"Classifying brain damage in preterm infants","volume":"134","author":"Paneth","year":"1999","journal-title":"J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00913693","article-title":"The Brazelton Neonatal Behavioral Assessment Scale (BNBAS)","volume":"5","author":"Als","year":"1977","journal-title":"J. Abnorm. Child Psychol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1741-6787.2009.00150.x","article-title":"Newborn Individual Development Care and Assessment Program (NIDCAP): A Systematic Review of the Literature","volume":"6","author":"Wallin","year":"2009","journal-title":"Worldviews Evid. Based Nurs."},{"key":"ref_23","first-page":"CD001071","article-title":"Non-nutritive sucking for increasing physiologic stability and nutrition in preterm infants","volume":"10","author":"Foster","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijporl.2019.02.005","article-title":"The effects of premature infant oral motor intervention (PIOMI) on oral feeding of preterm infants: A randomized clinical trial","volume":"120","author":"Ghomi","year":"2019","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/bfm.2018.0014","article-title":"Oral Sensorimotor Intervention Enhances Breastfeeding Establishment in Preterm Infants","volume":"13","author":"Fucile","year":"2018","journal-title":"Breastfeed. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s13312-018-1357-6","article-title":"Prefeeding Oromotor Stimulation Program for Improving Oromotor Function in Preterm Infants\u2014A Randomized Controlled Trial","volume":"55","author":"Arora","year":"2018","journal-title":"Indian Pediatr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s13312-016-0786-3","article-title":"Oromotor stimulation for transition from gavage to full oral feeding in preterm neonates: A Randomized controlled trial","volume":"53","author":"Bala","year":"2016","journal-title":"Indian Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1590\/2317-1782\/20152014104","article-title":"Preterm newborn readiness for oral feeding: Systematic review and meta-analysis","volume":"27","author":"Lima","year":"2015","journal-title":"CoDAS"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.earlhumdev.2006.08.003","article-title":"A randomized study of the efficacy of sensory-motor-oral stimulation and non-nutritive sucking in very low birthweight infant","volume":"83","author":"Rocha","year":"2007","journal-title":"Early Hum. Dev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e1310","DOI":"10.1097\/MD.0000000000001310","article-title":"Oral Motor Intervention Improved the Oral Feeding in Preterm Infants: Evidence Based on a Meta-Analysis with Trial Sequential Analysis","volume":"94","author":"Tian","year":"2015","journal-title":"Medicine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/ANC.0b013e3182115a2a","article-title":"Effect of the Premature Infant Oral Motor Intervention on Feeding Progression and Length of Stay in Preterm Infants","volume":"11","author":"Lessen","year":"2011","journal-title":"Adv. Neonatal Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/PCC.0000000000000182","article-title":"Effect of Nonnutritive Sucking and Oral Stimulation on Feeding Performance in Preterm Infants: A Randomized Controlled Trial","volume":"15","author":"Zhang","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1044\/1058-0360(2010\/09-0067)","article-title":"Evidence-Based Systematic Review: Effects of Oral Motor Interventions on Feeding and Swallowing in Preterm Infants","volume":"19","author":"Arvedson","year":"2010","journal-title":"Am. J. Speech-Lang. Pathol."},{"key":"ref_34","first-page":"181","article-title":"Effect of oral stimulation on feeding performance and weight gain in preterm neonates: A randomised controlled trial","volume":"38","author":"Thakkar","year":"2018","journal-title":"Paediatr. Int. Child Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.earlhumdev.2013.12.011","article-title":"Effects of pre-feeding oral stimulation on oral feeding in preterm infants: A randomized clinical trial","volume":"90","author":"Bache","year":"2014","journal-title":"Early Hum. Dev."},{"key":"ref_36","first-page":"626","article-title":"Early Premature Infant Oral Motor Intervention Improved Oral Feeding and Prognosis by Promoting Neurodevelopment","volume":"37","author":"Li","year":"2019","journal-title":"Am. J. Perinatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/ANC.0000000000000543","article-title":"Early Intervention to Improve Sucking in Preterm Newborns: A Systematic Review of Quantitative Studies","volume":"19","author":"Grassi","year":"2019","journal-title":"Adv. Neonatal Care"},{"key":"ref_38","first-page":"371","article-title":"The Effectiveness of an Oral Sensorimotor Stimulation Protocol for the Early Achievement of Exclusive Oral Feeding in Premature Infants. A Randomized, Controlled Trial","volume":"40","year":"2019","journal-title":"Phys. Occup. Ther. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1651-2227.2008.00943.x","article-title":"Non-nutritive sucking scoring system for preterm newborns","volume":"97","author":"Neiva","year":"2008","journal-title":"Acta Paediatr."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/12\/1188\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:49:18Z","timestamp":1760168958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/8\/12\/1188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["children8121188"],"URL":"https:\/\/doi.org\/10.3390\/children8121188","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-129410\/v1","asserted-by":"object"}]},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]}}}