{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:16Z","timestamp":1787836696874,"version":"build-2784847793"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006254","name":"Ruhr University Bochum","doi-asserted-by":"publisher","award":["K133-19"],"award-info":[{"award-number":["K133-19"]}],"id":[{"id":"10.13039\/501100006254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Vitelline duct anomalies (VDA, including Meckel\u2019s diverticulum (MD)) result from failed embryologic obliteration. This study aimed for characteristics in symptomatic versus asymptomatic VDA, analyzing clinico-laboratory data from 73 children, aged 1 day to 17 years, treated at a tertiary Pediatric Surgery Institution from 2002\u20132017. A male preponderance was obtained (ratio 3.6:1). MD accounted for 85% of VDA. Incidence of symptomatic VDA decreased with older age. Leading symptoms were intestinal obstruction and hemorrhage. Mucosal heterotopia (present in 39% of symptomatic MD) was associated with anemia and lowered CRP-levels. On ROC-analysis, hemoglobin &lt; 8.6 g\/dL, CRP &lt; 0.6 mg\/dL and MD distance to ileocecal valve &gt;40 cm were predictors of ectopic tissue in symptomatic MD. Our data confirmed known characteristics as male preponderance, declined incidence of symptomatic cases with age and predominance of gastric ectopia in symptomatic MD. Moreover, anemia and prolonged distance of MD to ileocecal valve were predictors of ectopic mucosa in symptomatic MD.<\/jats:p>","DOI":"10.3390\/children9010035","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T22:51:50Z","timestamp":1641250310000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Meckel\u2019s Diverticulum in Children: A Monocentric Experience and Mini-Review of Literature"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-8127","authenticated-orcid":false,"given":"Matthias","family":"Nissen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Marien Hospital Witten, St. Elisabeth Gruppe, Ruhr-University of Bochum, Marienplatz 2, D-58452 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Marien Hospital Witten, St. Elisabeth Gruppe, Ruhr-University of Bochum, Marienplatz 2, D-58452 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Rogge","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Marien Hospital Witten, St. Elisabeth Gruppe, Ruhr-University of Bochum, Marienplatz 2, D-58452 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Alrefai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Marien Hospital Witten, St. Elisabeth Gruppe, Ruhr-University of Bochum, Marienplatz 2, D-58452 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Bodo","family":"Tr\u00f6bs","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, St. Johannes Hospital, Helios Group, An der Abtei 7 bis 11, D-47166 Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pedneo.2013.12.005","article-title":"Diverse presentations in pediatric Meckel\u2019s diverticulum: A review of 100 cases","volume":"55","author":"Huang","year":"2014","journal-title":"Pediatr. 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