{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:43:55Z","timestamp":1760363035304,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The common clinical manifestations of Meckel\u2019s diverticulum include painless lower gastrointestinal bleeding and intestinal obstruction due to intussusception. Intussusception induced by inverted Meckel\u2019s diverticulum has rarely been reported; furthermore, there is no report thus far of chronic nocturnal abdominal pain as a presenting symptom in children with Meckel\u2019s diverticulum. A 4-year-and-10-month-old girl with no significant history of previous illness presented with the sole complaint of chronic nocturnal abdominal pain for 3 months. The patient was reported to be asymptomatic during the day. A provisional diagnosis of chronic ileoileal intussusception was already under consideration in her previous hospital visits elsewhere. Physical examination revealed a soft, non-distended abdomen without tenderness. Imaging studies revealed ileoileal intussusception. Exploratory laparotomy showed ileoileal intussusception induced by an inverted Meckel\u2019s diverticulum with ulceration. The patient underwent successful surgery and made a full recovery. We report this case to remind physicians that Meckel\u2019s diverticulum should be considered in differential diagnosis of children presenting with the isolated symptom of chronic nocturnal abdominal pain.<\/jats:p>","DOI":"10.3390\/children9010069","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T20:42:16Z","timestamp":1641415336000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Nocturnal Abdominal Pain as the Presentation of Inverted Meckel Diverticulum: A Case Report"],"prefix":"10.3390","volume":"9","author":[{"given":"Ting-Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, E-Da Hospital, Kaohsiung City 824005, Taiwan"},{"name":"Department of Pediatrics, U-Sheng Hospital, Pingtung City 900023, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tsun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, E-Da Hospital, Kaohsiung City 824005, Taiwan"},{"name":"School of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Jui","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, E-Da Hospital, Kaohsiung City 824005, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yea-Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, E-Da Hospital, Kaohsiung City 824005, Taiwan"},{"name":"School of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Hung","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung City 807387, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, E-Da Hospital, Kaohsiung City 824005, Taiwan"},{"name":"School of Medicine, I-Shou University, Kaohsiung City 824005, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12154","DOI":"10.1097\/MD.0000000000012154","article-title":"Systematic review of epidemiology, presentation, and management of Meckel\u2019s diverticulum in the 21st century","volume":"97","author":"Hansen","year":"2018","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6640660","DOI":"10.1155\/2021\/6640660","article-title":"The Clinical Manifestation Variety and Management Choice of Meckel\u2019s Diverticulum with Complication: A Single Center Experience","volume":"2021","author":"Fu","year":"2021","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/ca.21099","article-title":"Intussusception: An anatomical perspective with review of the literature","volume":"24","author":"Loukas","year":"2011","journal-title":"Clin. Anat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/apa.13567","article-title":"Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants","volume":"105","author":"Fiegel","year":"2016","journal-title":"Acta Paediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1148\/radiol.09090090","article-title":"Case 156: Inverted Meckel diverticulum","volume":"255","author":"Kim","year":"2010","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13256-021-02736-2","article-title":"Inverted Meckel\u2019s diverticulum: A case report","volume":"15","author":"Bains","year":"2021","journal-title":"J. Med. Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1541.e1","DOI":"10.1016\/j.ajem.2020.03.034","article-title":"The rule of two\u2019s didn\u2019t work: Meckel\u2019s diverticulum with hemorrhagic shock in an adolescent","volume":"38","author":"Spangler","year":"2020","journal-title":"Am. J. Emerg. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.12998\/wjcc.v8.i2.306","article-title":"Recurrent lymphoma presenting as painless, chronic intussusception: A case report","volume":"8","author":"Giroux","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3346\/jkms.2016.31.2.321","article-title":"Chronic Intussusception Caused by Diffuse Large B-Cell Lymphoma in a 6-Year-Old Girl Presenting with Abdominal Pain and Constipation for 2 Months","volume":"31","author":"Choi","year":"2016","journal-title":"J. Korean Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1440-1746.1996.tb01694.x","article-title":"Chronic upper abdominal pain due to duodenal ulcer and other structural and functional causes: Its localization and nocturnal occurrence","volume":"11","author":"Kang","year":"1996","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Orfei, M., Gasparetto, M., Hensel, K.O., Zellweger, F., Heuschkel, R.B., and Zilbauer, M. (2021). Guidance on the interpretation of faecal calprotectin levels in children. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246091"},{"key":"ref_12","unstructured":"Brandler, J., and Chey, W.D. (2020). Fishing for Irritable Bowel Syndrome: Which Alarm Features Weave the Best Net?. Clin. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/MCG.0000000000000854","article-title":"World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease","volume":"51","author":"Hunt","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_14","unstructured":"Kleinman, R.E., Goulet, O.J., Mieli-Vergani, G., Sanderson, I.R., Sherman, P.M., and Shneider, B.L. (2018). Imaging of Pediatric Gastrointestinal Disease. Walker\u2019s Pediatric Gastrointestinal Disease: Pathology, Diagnosis, Management, PMPH USA, Ltd.. [6th ed.]."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/1\/69\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:26:45Z","timestamp":1760362005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/1\/69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["children9010069"],"URL":"https:\/\/doi.org\/10.3390\/children9010069","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}