{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:53:45Z","timestamp":1791392025842,"version":"4.3.3"},"reference-count":16,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Kawasaki disease (KD) is a systematic inflammatory disease with multiple organ involvement. Timely diagnosis and prompt management are essential for successful treatment. KD, with an atypical presentation, remains a diagnostic challenge for physicians. We report a five-year-old boy who presented with appendicitis. An appendectomy was performed; however, his fever persisted. The boy was diagnosed with KD and intravenous immunoglobulin was administered. His symptoms resolved, and he had an uneventful recovery. Furthermore, we performed a literature review with 13 cases identified in the literature. Most cases were male, and the average age was older than typical for KD. In conclusion, KD may present with abdominal complaints and appendicitis may be a rare initial presentation of KD. Multidisciplinary cooperation and high awareness are warranted for timely diagnosis, especially in older children experiencing persistent fever after an appendectomy.<\/jats:p>","DOI":"10.3390\/children9020193","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T05:42:33Z","timestamp":1643866953000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Appendicitis as a Leading Manifestation of Kawasaki Disease in Older Children"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9843-5189","authenticated-orcid":false,"given":"Ya-Ning","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, MacKay Children\u2019s Hospital, Taipei 10449, Taiwan"},{"name":"Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Hang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan"},{"name":"Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu City 30071, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0433-1072","authenticated-orcid":false,"given":"Yu-Lin","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Cherng","family":"Duh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan"},{"name":"MacKay Junior College of Medicine, Nursing and Management, New Taipei City 25245, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-8724","authenticated-orcid":false,"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan"},{"name":"Department of Medicine, MacKay Medical College, New Taipei City 25160, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11926-020-00941-4","article-title":"Kawasaki disease: An update","volume":"22","author":"Rife","year":"2020","journal-title":"Curr. 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Med."},{"key":"ref_16","first-page":"e10722","article-title":"A case of multisystem inflammatory syndrome in children mimicking acute appendicitis in a COVID-19 pandemic area","volume":"12","author":"Jackson","year":"2020","journal-title":"Cureus"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/2\/193\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:13:19Z","timestamp":1760134399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/2\/193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["children9020193"],"URL":"https:\/\/doi.org\/10.3390\/children9020193","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]}}}