{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:26:29Z","timestamp":1768407989499,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: The anatomical location of the appendix in females determines its close contact with the internal genitalia, involving the latter in case of acute appendicitis (AA). The aim of this study was to evaluate the incidence of pelvic health impairment in adult women who underwent appendicectomy during childhood. Materials and Methods: A retrospective observational study was conducted including all female patients who underwent appendicectomy for acute appendicitis at our Center between January 1985 and December 1995. The patients were divided into two groups, i.e., complicated AA (Group A) and not complicated AA (Group B), and were asked to respond to a questionnaire investigating their general health status, fertility impairment, ectopic pregnancies, miscarriages, endometriosis, and chronic pelvic pain. The same questionnaire was administered to female volunteers with past medical history (PMH) negative for AA. The data were compared using chi-square test and Fisher exact test (a p value &lt; 0.05 was considered for statistical significance). Results: In total, 75 patients operated for AA during childhood (22 in Group A and 53 in group B) and 44 female volunteers with PMH negative for AA (group C) were enrolled in the study. Seventeen patients (77.3%) in group A, 40 (75.4%) in group B, and 29 (65.9%) in group C (p &gt; 0.05) had pregnancies. The number of miscarriages among women who became pregnant in their life was 5 in group A, 13 in group B, and 12 in group C (p &gt; 0.05). Chronic pelvic pain was reported by 7 out of 22 (31.8%) patients in group A, 7 out of 53 (13.2%) in group B, and 5 out of 44 (11.4%) in group C (A vs. C: p = 0.04, OR = 3.64; A vs. B: p = 0.06 and B vs. C: p = 0.52). Conclusions: In our series, AA, complicated or not, neither determined repercussions on fertility, risk of miscarriages, and ectopic pregnancies nor increased the risk of developing endometriosis. However, women who experienced complicated AA showed a higher prevalence of chronic pelvic pain onset in adulthood compared to healthy women.<\/jats:p>","DOI":"10.3390\/children9030346","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T22:53:25Z","timestamp":1646261605000},"page":"346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pelvic Health Assessment in Adult Females Following Pediatric Appendicitis: A Monocentric Retrospective Case\u2014Control Study"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-651X","authenticated-orcid":false,"given":"Giovanni","family":"Parente","sequence":"first","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-579X","authenticated-orcid":false,"given":"Marco","family":"Di Mitri","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Cravano","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduje","family":"Thomas","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Vastano","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-9219","authenticated-orcid":false,"given":"Robert","family":"Lunca","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Gargano","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Libri","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-440X","authenticated-orcid":false,"given":"Mario","family":"Lima","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, IRCCS Sant\u2019Orsola Polyclinic, Alma Mater Studiorum\u2014University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00268-012-1749-z","article-title":"Examining a common disease with unknown etiology: Trends in epidemiology and surgical management of appendicitis in California","volume":"36","author":"Anderson","year":"2012","journal-title":"Calif. 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Int."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/3\/346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:31:07Z","timestamp":1760135467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/3\/346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["children9030346"],"URL":"https:\/\/doi.org\/10.3390\/children9030346","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]}}}