{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:57:19Z","timestamp":1760151439114,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objectives: The aim of this paper is to describe a case series of paediatric patients affected by anastomotic ulcers (AU), a late complication of bowel resection in infancy, focusing on the treatment of iron-deficiency anaemia (IDA) with ferric carboxymaltose (FC). Methods: Patients with a diagnosis of AU, treated at the Paediatric Department of the Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo\u201d from February 2012 to December 2020 were included. Haemoglobin (Hb) values, IDA related symptoms, the need for blood transfusions, for oral or intravenous (iv) iron supplementation and for surgical resections were compared before and after treatment with FC. Adverse effects of FC were recorded. Results: Ten patients with an established diagnosis of AU were identified; eight (8 out of 10) received at least one administration of FC. Lower and higher Hb values increased significantly after treatment (4.9 g\/dL vs. 8.2 g\/dL, p = 0.0003; 9.9 g\/dL vs. 13.5 g\/dL, p = 0.0008 respectively), with a significant reduction of the need for blood transfusions (p = 0.0051) and for oral and iv iron supplementation. While receiving standard therapies, seven patients (7 out of 8) complained of asthenia; this symptom resolved in all cases after FC administration. Before FC treatment, two patients (2 out of 8) required surgical resection of AU, with a recurrence of anaemia after a few weeks; after at least one FC infusion, no children needed further bowel resection for IDA. FC caused mild asymptomatic hypophosphatemia in one case. Conclusion: FC appears to be effective and safe in the paediatric population for the treatment of IDA resulting from AU.<\/jats:p>","DOI":"10.3390\/children9030378","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:30:38Z","timestamp":1646825438000},"page":"378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferric Carboxymaltose in the Treatment of Iron-Deficiency Anaemia in Paediatric Patients with Anastomotic Ulcers"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5784-3768","authenticated-orcid":false,"given":"Chiara","family":"Udina","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Medical Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Andrea","family":"Lanzetta","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-8463","authenticated-orcid":false,"given":"Fulvio","family":"Celsi","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egidio","family":"Barbi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Medical Sciences, University of Trieste, 34127 Trieste, Italy"},{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Gortani","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5249-8248","authenticated-orcid":false,"given":"Matteo","family":"Bramuzzo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MPG.0000000000000472","article-title":"Anastomotic ulcerations after intestinal resection in infancy","volume":"59","author":"Chardot","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0022-3468(88)80727-9","article-title":"Ileocolic ulceration: A long- term complication following ileocolic anastomosis","volume":"23","author":"Parashar","year":"1988","journal-title":"J. Pediatr. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jpedsurg.2017.05.030","article-title":"Anastomotic ulcers in short bowel syndrome: New suggestions from a multidisciplinary apiproach","volume":"53","author":"Fusaro","year":"2018","journal-title":"J. Pediatr. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/joim.13004","article-title":"Iron deficiency anaemia revisited","volume":"287","author":"Cappellini","year":"2020","journal-title":"J. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/MPG.0000000000001684","article-title":"Intravenous Iron Sucrose for Treatment of Iron Deficiency Anemia in Pediatric Inflammatory Bowel Disease","volume":"66","author":"Stein","year":"2018","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1111\/j.1572-0241.2005.00250.x","article-title":"Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study","volume":"100","author":"Schroder","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/ajkd.2001.28587","article-title":"Intravenous iron sucrose: Establishing a safe dose","volume":"38","author":"Chandler","year":"2001","journal-title":"Am. J. Kidney Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21037\/tp.2019.01.01","article-title":"Ferric carboxymaltose in the treatment of iron deficiency in pediatric inflammatory bowel disease","volume":"8","author":"Carman","year":"2019","journal-title":"Transl. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jpeds.2016.09.053","article-title":"Intravenous Ferric Carboxymaltose in Children with Iron Deficiency Anemia Who Respond Poorly to Oral Iron","volume":"180","author":"Powers","year":"2017","journal-title":"J. Pediatr."},{"key":"ref_10","first-page":"454","article-title":"Late gastrointestinal bleeding and protein loss after distal small-bowel resection in infancy","volume":"9","author":"Couper","year":"1989","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_11","first-page":"25","article-title":"Chronic anemia secondary to side-to-side distal small bowel anastomosis","volume":"93","author":"Bosmans","year":"1993","journal-title":"Acta Chir. Belg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1136\/adc.67.11.1385","article-title":"Severe anaemia and ileocolic anastomotic ulceration","volume":"67","author":"Hamilton","year":"1992","journal-title":"Arch. Dis. Child."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000496966","article-title":"Safety of Oral and Intravenous Iron","volume":"142","author":"DeLoughery","year":"2019","journal-title":"Acta Haematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s40265-018-0885-7","article-title":"Ferric Carboxymaltose: A Review in Iron Deficiency","volume":"78","author":"Scott","year":"2018","journal-title":"Drugs"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/3\/378\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:33:30Z","timestamp":1760135610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/3\/378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["children9030378"],"URL":"https:\/\/doi.org\/10.3390\/children9030378","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}