{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:50:40Z","timestamp":1790351440971,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Cardiovascular alterations in anorexia nervosa (AN) adolescents include bradycardia and decreased systolic blood pressure and left ventricular mass. However, their determinants remain poorly understood. We assessed the associations between morphological and functional left ventricular (LV) remodeling, autonomic control by heart rate variability (HRV) analysis, thyroid hormones and brain natriuretic peptide (BNP) levels in AN female adolescents without or with weight recovery (WR). Fifty-nine female adolescents including 16 AN patients without WR (mean age 13.9 years (10\u201316)), 10 AN patients with WR (15.7 years (12\u201318)) and 33 controls (14.1 years (10\u201318)) underwent night heart rate (HR) recording to measure HRV (and especially SD1\/SD2, the ratio between instantaneous (SD1) and long-term (SD2) standard deviation of R-R intervals, reflecting sympatho-vagal balance), speckle tracking echocardiography to assess LV global longitudinal strain (GLS) and blood test for dosage of tri-iodothyronine (T3) hormone and NT-proBNP. Compared to controls, AN patients without WR presented with lower HR (55 \u00b1 7 vs. 68 \u00b1 6 bpm; p &lt; 0.001), parasympathetic hyperactivity, and higher GLS (\u221219.2 \u00b1 1.8 vs. \u221216.9 \u00b1 2.8%; p = 0.009). These alterations were partly abolished in AN patients with WR. In a multivariate regression analysis, T3 was the main factor explaining the variance of SD1\/SD2, a sympatho-vagal balance marker. NT-proBNP levels were not correlated with cardiac alterations. AN patients had parasympathetic hyperactivity linked with their rate of T3, and a higher GLS. These alterations were partly restored in AN patients with WR.<\/jats:p>","DOI":"10.3390\/children9040458","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:05:18Z","timestamp":1648166718000},"page":"458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery"],"prefix":"10.3390","volume":"9","author":[{"given":"Justine","family":"Paysal","sequence":"first","affiliation":[{"name":"LAPEC UPR 4278, Avignon University, 84000 Avignon, France"},{"name":"N\u00e9onatologie et R\u00e9animation P\u00e9diatrique, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Thireau","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, PhyMedExp, University of Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Terral","sequence":"additional","affiliation":[{"name":"P\u00e9diatrie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-9916","authenticated-orcid":false,"given":"Emmanuelle","family":"Rochette","sequence":"additional","affiliation":[{"name":"P\u00e9diatrie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"},{"name":"INSERM, CIC 1405, Unit\u00e9 CRECHE, Universit\u00e9 Clermont Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Obert","sequence":"additional","affiliation":[{"name":"LAPEC UPR 4278, Avignon University, 84000 Avignon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Merlin","sequence":"additional","affiliation":[{"name":"P\u00e9diatrie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"},{"name":"INSERM, CIC 1405, Unit\u00e9 CRECHE, Universit\u00e9 Clermont Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nottin","sequence":"additional","affiliation":[{"name":"LAPEC UPR 4278, Avignon University, 84000 Avignon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00431-005-1647-6","article-title":"Cardiac Findings in Adolescents with Anorexia Nervosa at Diagnosis and after Weight Restoration","volume":"164","author":"Olivares","year":"2005","journal-title":"Eur. 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