{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T03:29:07Z","timestamp":1762054147129,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Excellence, performance, and competitiveness in biomedical research at the Ovidius University of Constanta"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Platelet indices represent useful biomarkers to express the thromboembolic status, inflammatory response, and oxidative stress in preterm newborns. Our study presented platelet count and function changes in prematurity-related morbidities such as respiratory distress syndrome, intraventricular bleeding, and anemia of prematurity in preterm newborn cases reported to healthy full-term newborns by flow cytometry and hematological methods. The platelet volume represents the average size of platelets in the blood samples, showing the significantly increased values in preterm newborns compared with healthy full-term newborns due to increasing activated platelet production. Flow cytometric analysis of immature platelet fractions (IPF) made using thiazole orange staining to detect their mRNA content and a glycoprotein (anti-GPIIIa) antibody for platelet gating. CD61-TO expression from premature newborns was significantly lower compared to healthy full-term neonates. Preterm newborn cases with respiratory distress syndrome and a need for respiratory support (RDS+) were characterized by a significantly increased platelet volume and a decreased immature platelet fraction reported in RDS\u2212 cases. Evaluating the platelet function in the newborn is difficult because the laboratory methodologies work with small quantities of newborn blood samples. The immature platelet fractions and platelet volume promise to be diagnostic biomarkers for diseases.<\/jats:p>","DOI":"10.3390\/children9060791","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:40:45Z","timestamp":1653702045000},"page":"791","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Platelet Function in Preterm Newborns with Prematurity Related Morbidities"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-0943","authenticated-orcid":false,"given":"Irina","family":"Franciuc","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 Universitatii Street, 900470 Constanta, Romania"},{"name":"Neonatology Department, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-7739","authenticated-orcid":false,"given":"Elena","family":"Matei","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Aschie","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"},{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Mitroi","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"},{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Chisoi","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"},{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ionut","family":"Poinareanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 Universitatii Street, 900470 Constanta, Romania"},{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolae","family":"Dobrin","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea Georgiana","family":"Stoica","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"},{"name":"Internal Medicine-Hematology Department, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7370-9489","authenticated-orcid":false,"given":"Traian Virgiliu","family":"Surdu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 Universitatii Street, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Manea","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Topliceanu","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgeta Camelia","family":"Cozaru","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, CEDMOG, 145 Tomis Blvd., 900591 Constanta, Romania"},{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.blre.2004.05.002","article-title":"Platelet function analysis","volume":"19","author":"Harrison","year":"2005","journal-title":"Blood Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1126\/science.328.5978.562","article-title":"Beyond clotting: The powers of platelets","volume":"328","author":"Leslie","year":"2010","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.immuni.2017.03.009","article-title":"Protecting the newborn and young infant from infectious diseases: Lessons from immune ontogeny","volume":"46","author":"Kollmann","year":"2017","journal-title":"Immunity"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jns.2011.11.019","article-title":"Inflammatory response to intraventricular hemorrhage: Time course, magnitude, and effect of t-PA","volume":"315","author":"Hallevi","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Esiaba, I., Mousselli, I., Faison, G.M., Angeles, D.M., and Boskovic, D.S. (2019). Platelets in the Newborn. Neonatal Medicine, IntechOpen.","DOI":"10.5772\/intechopen.86715"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/PDR.0b013e3181c1b176","article-title":"Intraventricular hemorrhage in premature infants: Mechanism of disease","volume":"567","author":"Ballabh","year":"2010","journal-title":"Pediatr. Res."},{"key":"ref_7","first-page":"328","article-title":"Intraventricular hemorrhage in premature infants with respiratory distress syndrome treated with surfactant: Incidence and risk factors in the prospective cohort study","volume":"21","author":"Helwich","year":"2017","journal-title":"Dev. Period Med."},{"key":"ref_8","first-page":"CD012185","article-title":"Heparin for the treatment of thrombosis in neonates","volume":"11","author":"Romantsik","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/09537100701206816","article-title":"Does prematurity affect thrombocytopoiesis?","volume":"18","author":"Wasiluk","year":"2007","journal-title":"Platelets"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1182\/asheducation.V2012.1.506.3798532","article-title":"Platelets in the neonatal period: Developmental differences in platelet production, function, and hemostasis and the potential impact of therapies","volume":"2012","year":"2012","journal-title":"Hematology"},{"key":"ref_11","first-page":"797","article-title":"Reticulated platelet percentages in term and preterm neonates","volume":"26","author":"Saxonhouse","year":"2004","journal-title":"J. Pediatric Hematol. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/09537100400016862","article-title":"Neonatal platelets from cord blood and peripheral blood","volume":"16","author":"Sitaru","year":"2005","journal-title":"Platelets"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4103\/2249-4847.140399","article-title":"Effect of gestational age, prematurity, and birth asphyxia on platelet indices in neonates","volume":"3","author":"Kannar","year":"2014","journal-title":"J. Clin. Neonatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2478\/v10039-011-0030-2","article-title":"Platelet indices in SGA newborns","volume":"56","author":"Wasiluk","year":"2011","journal-title":"Adv. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/jog.12484","article-title":"Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes?","volume":"41","author":"Ekin","year":"2015","journal-title":"J. Obstet. Gynecol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1442-200X.2009.02820.x","article-title":"Mean platelet volume in neonatal respiratory distress syndrome","volume":"51","author":"Canpolat","year":"2009","journal-title":"Pediatr. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1538-7836.2007.02537.x","article-title":"Platelet integrin \u03b1 (IIb) \u03b2 (3): Activation mechanisms","volume":"5","author":"Ma","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1182\/blood-2004-04-1257","article-title":"Integrins: Dynamic scaffolds for adhesion and signaling in platelets","volume":"104","author":"Shattil","year":"2004","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.thromres.2007.03.011","article-title":"The role of von Willebrand factor in thrombus formation","volume":"120","author":"Ruggeri","year":"2007","journal-title":"Thromb. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1081\/RRS-120034252","article-title":"Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa","volume":"24","author":"Sobocka","year":"2004","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1182\/blood-2005-01-0333","article-title":"Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling","volume":"106","author":"Nanda","year":"2005","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nm0302-247","article-title":"CD40L stabilizes arterial thrombi by a beta3 integrin\u2013dependent mechanism","volume":"8","author":"Andre","year":"2002","journal-title":"Nat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1160\/THS10-11-0720","article-title":"Platelets, inflammation, and tissue regeneration","volume":"105","author":"Nurden","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1160\/TH03-04-0213","article-title":"The functional role of blood platelet components in angiogenesis","volume":"92","author":"Rhee","year":"2004","journal-title":"Thromb. Haemost."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1515\/cclm-2014-0165","article-title":"Reticulated platelets: Analytical aspects and clinical utility","volume":"52","author":"Hoffmann","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cca.2014.10.024","article-title":"Clinical applicability of reticulated platelets","volume":"439","author":"Dusse","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3109\/09537100903207505","article-title":"Thrombopoiesis in small for gestational age newborns","volume":"20","author":"Wasiluk","year":"2009","journal-title":"Platelets"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2478\/v10039-009-0034-3","article-title":"Does prematurity affect platelet indices?","volume":"54","author":"Wasiluk","year":"2009","journal-title":"Adv. Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/jp.2008.141","article-title":"Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system","volume":"29","author":"Wiedmeier","year":"2009","journal-title":"J. Perinatol."},{"key":"ref_30","first-page":"124","article-title":"Flow cytometric investigation of classical and alternative platelet activation markers","volume":"23","author":"Nagy","year":"2013","journal-title":"J. Int. Fed. Clin. Chem. Lab. Med."},{"key":"ref_31","first-page":"123","article-title":"Impact of preeclampsia on megakaryocytopoiesis and platelet homeostasis of preterm infants","volume":"27","author":"Yang","year":"2016","journal-title":"Platelets"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.jp.7211287","article-title":"Thrombopoietin level is increased in the serum of asphyxiated neonates: A prospective controlled study","volume":"25","author":"Aly","year":"2005","journal-title":"J. Perinatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1160\/TH14-02-0126","article-title":"The role of platelets in sepsis","volume":"112","author":"Poll","year":"2014","journal-title":"Thromb. Haemost."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.blre.2010.08.001","article-title":"Anemia of Prematurity: Pathophysiology & Treatment","volume":"24","author":"Strauss","year":"2010","journal-title":"Blood Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1537-2995.2004.03393.x","article-title":"Post-transfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants","volume":"44","author":"Strauss","year":"2004","journal-title":"Transfusion"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0022-3476(00)70105-3","article-title":"Changing practices of red blood cell transfusions in infants with birth weights less than 1000 g","volume":"136","author":"Maier","year":"2000","journal-title":"J. Pediatr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/2249-4847.123095","article-title":"Examination of the percentage of immature platelet fraction in term and preterm infants at birth","volume":"2","author":"Yuko","year":"2013","journal-title":"J. Clin. Neonatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/jp.2013.21","article-title":"Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis","volume":"33","author":"Cremer","year":"2013","journal-title":"J. Perinatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1111\/ijlh.13071","article-title":"The role of immature platelet fraction (IPF%) in full-term and preterm infants: Italian data of a promising clinical biomarker in neonates","volume":"42","author":"Garofoli","year":"2020","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/jp.2017.48","article-title":"The immature platelet fraction: Creating neonatal reference intervals and using these to categorize neonatal thrombocytopenias","volume":"37","author":"MacQueen","year":"2017","journal-title":"J. Perinatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2004.04987.x","article-title":"Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia","volume":"126","author":"Briggs","year":"2004","journal-title":"Br. J. Hematol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00134-012-2725-7","article-title":"Immature platelet fraction in predicting sepsis in critically ill patients","volume":"39","author":"Cardelli","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1038\/srep08019","article-title":"Association of the immature platelet fraction with sepsis diagnosis and severity","volume":"5","author":"Hubert","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e9424","DOI":"10.1097\/MD.0000000000009424","article-title":"Clinical significance of measuring reticulated platelets in infectious diseases","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine"},{"key":"ref_45","first-page":"409","article-title":"Can immature platelet fraction be an early predictor for congenital pneumonia?","volume":"55","author":"Er","year":"2020","journal-title":"Turk. Arch. Pediatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1177\/0300060517737211","article-title":"Are platelet volume indices related to mortality in hospitalized children on mechanical ventilation?","volume":"46","author":"Ye","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1080\/14767058.2017.1330329","article-title":"Role of mean platelet volume and ischemia modified albumin in the evaluation of oxidative stress and its association with postnatal complications in infants of diabetic mothers","volume":"3","author":"Mohsen","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fped.2020.00090","article-title":"Using Platelet Parameters to Anticipate Morbidity and Mortality among Preterm Neonates: A Retrospective Study","volume":"8","author":"Go","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_49","first-page":"749","article-title":"Mean platelet volume trend in sepsis: Is it a useful parameter?","volume":"72","author":"Becchi","year":"2006","journal-title":"Minerva Anestesiol."},{"key":"ref_50","first-page":"134","article-title":"Mean platelet volume in very preterm infants: A predictor of morbidities?","volume":"17","author":"Cekmez","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_51","first-page":"90","article-title":"Platelets in pregnancy","volume":"5","author":"Piazze","year":"2011","journal-title":"J. Prenat. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1469-0705.2002.00672.x","article-title":"Platelet changes and subsequent development of pre-eclampsia and fetal growth restriction in women with abnormal uterine artery Doppler screening","volume":"19","author":"Teran","year":"2002","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00404-005-0005-2","article-title":"The relation of increased uterine artery blood flow resistance and impaired trophoblast invasion in pre-eclamptic pregnancies","volume":"272","author":"Guzin","year":"2005","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1179\/102453308X315825","article-title":"Could mean platelet volume be a predictive marker for gestational diabetes mellitus?","volume":"13","author":"Erikci","year":"2008","journal-title":"Hematology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/09537100802630062","article-title":"Gestational diabetes: Is it linked to platelets hyperactivity?","volume":"20","author":"Gioia","year":"2009","journal-title":"Platelets"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/09537104.2010.509828","article-title":"Physiologic and pathologic changes of platelets in pregnancy","volume":"21","author":"Valera","year":"2010","journal-title":"Platelets"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Youn","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ccm.2004.01.010","article-title":"Pulmonary complications of pregnancy. Review","volume":"25","author":"Pereira","year":"2004","journal-title":"Clin. Chest Med."},{"key":"ref_59","first-page":"627","article-title":"Prevalence & consequences of anaemia in pregnancy","volume":"130","author":"Kalaivani","year":"2009","journal-title":"Indian J. Med. Res."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/6\/791\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:20:06Z","timestamp":1760138406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/6\/791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["children9060791"],"URL":"https:\/\/doi.org\/10.3390\/children9060791","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2022,5,27]]}}}