{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:30:39Z","timestamp":1792089039767,"version":"4.4.0"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Adolescent idiopathic scoliosis (AIS) is characterized by the radiographic presence of a frontal plane curve, with a magnitude greater than 10\u00b0 (Cobb technique). Diffusion MRI can be employed to assess the cerebral white matter. The aim of this study was to analyze, by means of MRI, the presence of any alteration in the connectivity of cerebral white matter in AIS patients. In this study, 22 patients with AIS participated. The imaging protocol consisted in T1 and diffusion-weighted acquisitions. Based on the information from one of the diffusion acquisitions, a whole brain tractography was performed with the MRtrix tool. Tractography is a method to deduce the trajectory of fiber bundles through the white matter based on the diffusion MRI data. By combining cortical segmentation with tractography, a connectivity matrix of size 84 \u00d7 84 was constructed using FA (fractional anisotropy), and the number of streamlines as connectomics metrics. The results obtained support the hypothesis that alterations in cerebral white matter connectivity in patients with adolescent idiopathic scoliosis (AIS) exist. We consider that the application of diffusion MRI, together with transcranial magnetic stimulation neurophysiologically, is useful to search the etiology of AIS.<\/jats:p>","DOI":"10.3390\/children9071023","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T21:19:28Z","timestamp":1657487968000},"page":"1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral White Matter Connectivity in Adolescent Idiopathic Scoliosis: A Diffusion Magnetic Resonance Imaging Study"],"prefix":"10.3390","volume":"9","author":[{"given":"David C.","family":"Noriega-Gonzalez","sequence":"first","affiliation":[{"name":"Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain"},{"name":"Traumatology and Orthopaedics Department, Hospital Cl\u00ednico Universitario de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Crespo","sequence":"additional","affiliation":[{"name":"Traumatology and Orthopaedics Department, Hospital Cl\u00ednico Universitario de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ardura","sequence":"additional","affiliation":[{"name":"Traumatology and Orthopaedics Department, Hospital Cl\u00ednico Universitario de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Calabia-del Campo","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Cl\u00ednico Universitario de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-0055","authenticated-orcid":false,"given":"Carlos","family":"Alberola-Lopez","sequence":"additional","affiliation":[{"name":"ETSI Telecomunicaci\u00f3n, Image Processing Laboratory. University of Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"de Luis-Garc\u00eda","sequence":"additional","affiliation":[{"name":"ETSI Telecomunicaci\u00f3n, Image Processing Laboratory. University of Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-0615","authenticated-orcid":false,"given":"Alberto","family":"Caballero-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Radiology, Health Sciences Faculty, GIR: \u201cPhysical Exercise and Aging\u201d, University of Valladolid, Campus Universitario \u201cLos Pajaritos\u201d, 42004 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Physiology, Health Sciences Faculty, GIR: \u201cPhysical Exercise and Aging\u201d, University of Valladolid, Campus Universitario \u201cLos Pajaritos\u201d, 42004 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1016\/j.neuroimage.2010.04.002","article-title":"Automatic MRI segmentation and morphoanatomy analysis of the vestibular system in adolescent idiopathic scoliosis","volume":"54","author":"Shi","year":"2011","journal-title":"NeuroImage"},{"key":"ref_2","first-page":"19","article-title":"Adolescent Idiopathic Scoliosis: Common Questions and Answers","volume":"101","author":"Kuznia","year":"2020","journal-title":"Am. 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