{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:00:21Z","timestamp":1760238021684,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Magnesium ions are implicated in brain functioning. The disruption of brain metabolism subsequent to a perinatal hypoxic-ischaemic insult may be reflected by plasma magnesium. Infants at 36 weeks after birth or later with neonatal encephalopathy and who were admitted to our neonatal unit from 2011 to 2019 were retrospectively included. The kinetics of plasma magnesium were investigated for the first 72 h of life and correlated to the Barkovich MRI score. Among the 125 infants who met the inclusion criteria, 45 patients (36%) had moderate to severe brain lesions on neonatal MRI. Plasma magnesium values were not strongly associated with the severity of clinical encephalopathy, initial EEG background and brain lesions. Intriguingly, higher plasma magnesium values during the 0\u20136 h period were linked to the presence of brain injuries that predominated within the white matter (p &lt; 0.001) and to the requirement of cardiac resuscitation in the delivery room (p = 0.001). The occurrence of seizures was associated with a lower mean magnesium value around the 24th hour of life (p = 0.005). This study supports that neonatal encephalopathy is a complex and multifactorial condition. Plasma magnesium could help to better identify the subtypes of neonatal encephalopathy. Further studies are needed to confirm these results in this prospect.<\/jats:p>","DOI":"10.3390\/children9081233","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T20:58:08Z","timestamp":1660597088000},"page":"1233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Plasma Magnesium in Near-Term and Term Infants with Neonatal Encephalopathy in the Context of Perinatal Asphyxia"],"prefix":"10.3390","volume":"9","author":[{"given":"Juliette","family":"Suhard","sequence":"first","affiliation":[{"name":"Neonatology Department, Regional University Hospital Centre Tours, 37000 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathie","family":"Faussat","sequence":"additional","affiliation":[{"name":"CoMeth Team, Public Health Department, Regional University Hospital Centre Tours, 37000 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Morel","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department, Regional University Hospital Centre Tours, 37000 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline","family":"Laurent","sequence":"additional","affiliation":[{"name":"CoMeth Team, Public Health Department, Regional University Hospital Centre Tours, 37000 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-2053","authenticated-orcid":false,"given":"Geraldine","family":"Favrais","sequence":"additional","affiliation":[{"name":"Neonatology Department, Regional University Hospital Centre Tours, 37000 Tours, France"},{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, INSERM, 37044 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F301","DOI":"10.1136\/archdischild-2017-313707","article-title":"Neonatal Brain Injuries in England: Population-Based Incidence Derived from Routinely Recorded Clinical Data Held in the National Neonatal Research Database","volume":"103","author":"Gale","year":"2018","journal-title":"Arch. 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