{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:34:06Z","timestamp":1760243646764,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapillary retinal nerve fibre layer (pRNFL) thickness at three time points: baseline (OCT1), end of treatment (OCT2), and at last follow-up (OCT3). We compared the median value of pRNFL (and interquartile range\u2014IQR) at different follow-up times and in different sub-groups (stable disease\u2014SD, partial response\u2014PR, and progression disease\u2014PD). Thirteen children younger than 5 years of age were included. The Median follow-up time was 3.9 years (IQR 1.2). Six patients showed a pRNFL change of more than 10% during follow-up. Seven patients showed PD during follow-up. Median pRNFL at baseline was 81.5 \u00b5m (IQR 31.5); median pRNFL at the end of treatment was 73 \u00b5m (IQR 33); median pRNFL at last follow-up was 72 \u00b5m (IQR 38.5). The mean pRNFL at baseline was significantly lower than the mean normative values. Only subjects with PD showed pRNFL change close to statistical significance. This study confirms the role of SD-OCT in managing OPGs for therapeutic decisions and strategy planning of visual rehabilitation.<\/jats:p>","DOI":"10.3390\/children9091307","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T21:22:56Z","timestamp":1661721776000},"page":"1307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age\u2014A Retrospective Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Rossana","family":"Pavone","sequence":"first","affiliation":[{"name":"Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children\u2019s Hospital, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Fonte","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children\u2019s Hospital, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-6524","authenticated-orcid":false,"given":"Iacopo","family":"Sardi","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children\u2019s Hospital, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Caputo","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Meyer Children\u2019s Hospital, Viale Pieraccini 24, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-9379","authenticated-orcid":false,"given":"Elisa","family":"Marziali","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Meyer Children\u2019s Hospital, Viale Pieraccini 24, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Mazzeo","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Meyer Children\u2019s Hospital, Viale Pieraccini 24, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Secci","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Meyer Children\u2019s Hospital, Viale Pieraccini 24, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Meyer Children\u2019s Hospital, Viale Pieraccini 24, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-9280","authenticated-orcid":false,"given":"Salvatore","family":"De Masi","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, Careggi Hospital, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmela","family":"Leo","sequence":"additional","affiliation":[{"name":"Clinical Research and Study Design Office, Meyer Children\u2019s Hospital, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luigia","family":"Censullo","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children\u2019s Hospital, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-4833","authenticated-orcid":false,"given":"Giacomo Maria","family":"Bacci","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology Unit, Meyer Children\u2019s Hospital, Viale Pieraccini 24, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/FOC-07\/11\/E2","article-title":"Optic pathway gliomas: A review","volume":"23","author":"Binning","year":"2007","journal-title":"Neurosurg. 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Child Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.21107","article-title":"Optic pathway gliomas in neurofibromatosis-1: Controversies and recommendations","volume":"61","author":"Listernick","year":"2007","journal-title":"Ann. 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