{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:52:29Z","timestamp":1763967149018,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Small airway dysfunction remains a stepchild in the pediatric asthma care pathway. In brief, elements of the pulmonary function test (PFT) concerning smaller airway data remain less utilized. To further the value of the standard PFT we underwent a prospective Proof of Concept (POC) project, utilizing the outpatient performance of PFT tests in children 6\u201318 years during a 15-month period. The goal of the study was to determine if a priori the PFT represented a small airway disease pattern or not. Only the pulmonary function was used to make that distinction. Children 6\u201318 years with asthma who completed a PFT had their PFT as being characterized with or without a small airway dysfunction (SAD) designation, coded in the electronic medical record as an a priori decision using the code J98.4 (other disorders of lung) as a marker for electronic medical records retrieval. Subsequently, the results were analyzed between a group of 136 children designated (a priori) as having no small airway dysfunction in comparison to 91 children a priori designated as having small airway dysfunction. The a priori designation groups were post hoc compared for large and smaller airway function differences. Both large and smaller airway dysfunction were highly significantly different between the 2 groups, based solely on the initial division of the total group based on the decision the PFT represented a small airway pattern. We concluded the baseline pulmonary function test used in the evaluation of pediatric asthma has readily identifiable information regarding the presence of small airway dysfunction, and we characterized what was unique on the PFT based on that SAD classification<\/jats:p>","DOI":"10.3390\/children9101454","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T21:14:28Z","timestamp":1664140468000},"page":"1454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An a Priori Approach to Small Airway Dysfunction in Pediatric Asthmatics"],"prefix":"10.3390","volume":"9","author":[{"given":"Russell","family":"Hopp","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Nebraska Medical Center, 42nd and Emile St., Omaha, NE 68198, USA"},{"name":"Children\u2019s Hospital and Medical Center, 8200 Dodge St., Omaha, NE 68114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghyae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Bohan","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital and Medical Center, 8200 Dodge St., Omaha, NE 68114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12016-020-08818-1","article-title":"Small Airway Disease in Pediatric Asthma: The Who, What, When, Where, Why, and How to Remediate. A Review and Commentary","volume":"62","author":"Hopp","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1164\/arrd.1972.106.6.873","article-title":"Small airway disease in asymptomatic asthmatic adolescents","volume":"106","author":"Hill","year":"1972","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/thx.34.2.217","article-title":"\u201cSmall airways disease\u201d in children: No test is best","volume":"34","author":"Landau","year":"1979","journal-title":"Thorax"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25898","DOI":"10.3402\/ecrj.v1.25898","article-title":"Technique of assessing small airway dysfunction","volume":"1","author":"McNulty","year":"2014","journal-title":"Eur. Clin. Respir. J."},{"key":"ref_5","first-page":"1584","article-title":"A compendium and review of pediatric pulmonary function testing assessment opportunities for asthma","volume":"30","author":"Hopp","year":"2021","journal-title":"J. Asthma"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S2213-2600(19)30049-9","article-title":"Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): Baseline data from a prospective cohort study","volume":"7","author":"Postma","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/j.jaip.2021.04.035","article-title":"Small Airway Dysfunction Links Asthma Severity with Physical Activity and Symptom Control","volume":"9","author":"Abdo","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1016\/j.jaip.2021.06.027","article-title":"FEF25-75 is a more sensitive measure reflecting airway dysfunction in patients with asthma: A comparison study using FEF25-5 and FEV1%","volume":"9","author":"Qin","year":"2021","journal-title":"J. Allergy Clin. Immunol. Prac."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/ACI.0000000000000728","article-title":"Small-airway dysfunction in paediatric asthma","volume":"21","author":"Cottini","year":"2021","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.anai.2018.07.026","article-title":"Small airway function in children with mild-to-moderate asthmatic symptoms and healthy controls","volume":"121","author":"Pelkonen","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e13647","DOI":"10.1111\/pai.13647","article-title":"Small airway dysfunction is an independent dimension of wheezing disease in preschool children","volume":"33","author":"Bokov","year":"2022","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1183\/20734735.012717","article-title":"The Global Lung Function Initiative (GLI) Network: Bringing the world\u2019s respiratory reference values together","volume":"13","author":"Cooper","year":"2017","journal-title":"Breathe"},{"key":"ref_13","unstructured":"SAS Institute Inc (2013). SAS\/ACCESS\u00ae 9.4 Interface to ADABAS: Reference, SAS Institute Inc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/bmj.310.6975.298","article-title":"Statistics notes: The normal distribution","volume":"310","author":"Altman","year":"1995","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0011-5029(88)90015-6","article-title":"Chronic obstructive pulmonary disease","volume":"34","author":"Flenley","year":"1988","journal-title":"Dis. Mon."},{"key":"ref_16","unstructured":"United States Department of Health and Human Services, National Institutes of Health (2007). Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaci.2017.09.047","article-title":"Obstruction phenotype as a predictor of asthma severity and instability in children","volume":"142","author":"Sorkness","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jaip.2021.12.026","article-title":"Oscillometry and Asthma Control in Patients With and Without Fixed Airflow Obstruction","volume":"10","author":"Cottee","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jaip.2021.09.029","article-title":"Peripheral Airway Impairment and Dysanapsis Define Risk of Uncontrolled Asthma in Obese Asthmatic Children","volume":"10","author":"Jung","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_20","unstructured":"American Lung Association (2022, August 30). Available online: https:\/\/www.lung.org\/research\/lung-health-cohort-study."},{"key":"ref_21","unstructured":"(2022, August 01). Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Available online: https:\/\/ginasthma.org\/wp-content\/uploads\/2022\/05\/GINA-Main-Report-2022-FINAL-22-05-03-WMS.pdf."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/10\/1454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:37:56Z","timestamp":1760143076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/10\/1454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["children9101454"],"URL":"https:\/\/doi.org\/10.3390\/children9101454","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2022,9,23]]}}}